-
Parotid gland
- largest salivary gland in retromandibular fossa
- temporo-mandibular jt to mandible
- overlap masseter
- to atlas
- eaar to intermandibular space
-
Parotid duct
- formed from ventral and rostral parotid gland
- medial mandible
- follows facial artery and vein
- opens into buccal vestible on parotid papilla opposite the upper third cheek tooth
-
trauma to parotid duct/gland
- bc superficial
- most common
- secrete saliva from wound which increases during eating
-
salivary fistula
- salivary secretions prevent healinf of parotid duct
- surgical repair (5-0 to 7-0 non absorb)
- translocation of duct to new opening in oral cavity
- chemical ablation with 10% formalin- least necrosis and inflammation
-
salivary mucocele
- skin stays intact and saliva accumulates in SQ
- collections of saliva in spaces not lined by epithelium
-
ranula
mucocele of the sublingual salivary gland
-
salivary cyst
- aberrent salivary tissue
- looks like hematoma
-
salivary fluid content
- higher K and Ca content
- alkaline pH
- amylase
- (compared to serum)
-
Sialoliths
- hard, nonpainful, moveable swellings that can obstruct the parotid duct
- possibly from old injury
- calcium carbonate and organic matter
- remove via oral approach to avoid salivay fistula
-
Salivary gland neoplasia
- rare
- adenocarcinoma, melenoma, mixed cell
- parotid swelling
-
parotid duct atresia
- congenital, rare, duct ends in cul-de-sac without penetrating oral mucosa
- surgical fix or chemical ablation
-
choke
- esophageal impaction
- feed and water reflux from nostrils and mouth
- excessive salivation
- feed impactions most common
-
diagnosis of choke
- palpation
- nasogastric intubation
- endoscopy
- radiology
-
tx choke
- lavage with warm water- must tranq horse to prevent aspiration (xylazine, detomidine)
- with draw food and water and leave alone for 12 hrs, repeat lavage
- choke relief tube with cuff on the end
- general anesthesia- head down
- NSAIDs (banamine) and Ab due to risk of aspiration pneumonia
- withhold feed for 24 hrs, then only feed soaked pellete for a few weeks
-
esophageal rupture
- chronic impation
- traumatic nasogastric intubation
- trauma to cervical area
- usually diatal third of cervical esophagus
- diverticulum if partial tear
- full tear results in dffuse swelling down the neck
- infection can extend into mediatinum giving a grave prognosis
-
tx esophageal rupture
- establish adewuate drainage
- place esophageal feeding tube (used for a few wks)
- NSAIDs and Ab
-
esophageal stricture
- sequella of choke, trauma, congenital
- finished healing after 60 days so no sx until then
- may get diverticulum in front of stricture
-
mural esophageal stricture
involving the adventitia and muscularis
-
esophageal rings or webs
involving the mucosa and submucosa
-
annumlar esophageal stricture
involves all layer
-
tx esophageal stricture
- mural- esophagotomy
- rings or webs and annular- mucosal and submucosal resection
- esophageal anastomosis
-
Common breed/gender colic issues
- Arabian- enterolithiasis
- miniature horse- impactions
- broodmares- large colon displacement
- stallions- inguinal hernias
- foals- meconium impaction, ruptured bladder
- older horses- lipomas, epipoic foramen entrapment, impaction, ascarids
- performance horses- gas colic
- coastal hay fed- ileal and cecal impaction
-
cause of colic pain
distention of hollow organs
-
drugs to manage pain from colic
- xylazine
- detomidine
- butorphanol
- n-butylscopolamine (Buscopan)- anti spasmodic, ant cholinergic
- NSAID- flunixin meglumine (banamine), ketoprofen, phenylbutazone
- lidocaine
-
non-drug tx for colic pain
- nasogastric decompression
- trocarization- only large colon distention
-
cardiovascular status of colic
- HR below 60 (unless Buscopan at 70)
- >80 needs CV support- 10 to 20L fluids
- intestinal secretions normally 30% of body wt- problems if sm int obstruction
-
upper left quadrant for GI auscultation
- stomach sounds
- empties in 2hrs so may be silent
-
upper right quadrant for GI ausculatation
cecum
-
lower left/right quadrant for GI auscultation
left/right colon
-
GI ausculation at xyphoid
sand
-
Reflux during nasogastric intubation
- not present normally
- small amount with large colon dz
- large amount with small intestine dz/obstruction
-
small intestine distention on rectal palpation
pass NG tube to see if reflux
-
cecal distention on rectal palpation
firm or gas
-
large colon distention on rectal palpation
- firm to left- pelvic flexure impaction
- ddx: gas, displacement, torsion, aboral obstruction
- transient response to meds- refer immediatley
-
small colon obstruction on rectal palpation
- no feces present cannot feel anything
- tug on band of cecum to see if painful
-
abdominocentesis
- 3 cm caudal to xyphoid process
- clip, scrub, sterile prep
- stab incision thru skin and body wall
- urinary catheter inserted
- fluid in and EDTA tube
- do not do if referring, foal, severe distention
-
normal/abnormal abdominocentesis
- normal: TP <2.5g/dl, WBC <5000 cell/ul
- abnormal: stanglulation= inc protein (1-2hr), yellow, RBC (3-4hr), orange, WBC inc (6hrs), lactate will be higher than peripheral blood
- will not see changes with large colon volvulus bc dead in 4 hrs
-
enterocentesis
- surgical rupture of intestine
- plant material, bacteria, no cells
- ddx: rupture but would see neut, bac, no plant material
-
Blood contamination during abdomenocentesis
- blood from skin vesseles will spin out with centrifuge
- freshblood will show platelets
- spleen- PCV higher than peripheral
- ddx: internal hemorrhage- hemolyzed and will not spin out, no platelets, erythrophagocytosis
-
post op changes vs peritonitis
- sx- inc TP and WBC
- peritonitis- inc TP and WBC, fever, depression, anorexia, pain, degenerate neut
-
endotoxin
LPS from gram neg bac which is a potent activator of the immune system
-
endotoxemia
presence of LPS in the bloodstream resulting in clinical signs
-
systemic inflammatory response syndrome (SIRS)
- general inflammatory response with 2 or more of following:
- hypothermia or pyrexia
- tachycardia
- tachypnea or hypocapnea
- WBC <5000/uL or >14,000/uL or >10% bands
-
Sepsis, septic shock
- sepsis- SIRS in response to infection
- septic shock- persistant hypotension secondary to sepsis that fails to respond to fluid resuscitation
-
multiple organ dysfunction syndrome (MODS)
insufficiency of 2 or more organ systems, commonly a sequel to endotoxic or septic shock
-
translocation of endotoxin from GI tract
- Kupffer cells normally clear
- dec clearance- hepatic dz
- inc absorption- mucosal barrier compromise, trauma, malnutrition
-
cellular interactions that help LPS
- LPS binding protein- enhance phagocytosis by macs and neut
- LPS binds to CD14 on neut
- TLR4 transmits signal to interior of cell
- signal causes phosphorylation and produces NFkb
- NFkb enters nucleus promoting transcription of inflammatory mediators
- also arachadonic acid metabolites
- results in neutrophil activation- neutropenia
- results in enothelial damage
-
clinical effects of endotoxemia
- acute, early hyperdynamic- anorexia, mild colic signs, sweating, tachycardia, "hot shock"
- fever, toxic line
- hypohynamic shock- dark mms, cold skin, ataxia, "cold endotoxemia"
- organ failure- icterus, laminitis
- leukopenia, inc PCV, azotemia
-
tx endotoxemia
- prevent further movement of endotoxin- remove nidus, binding agent
- neutralization of cirulating endotoxin- plasma, polymyxin B
- prevent prod and release of inf mediators- NSAIDs, DMSO, lidocaine
- supportive care- fluids, inotropic agents, oncotic support, tx coagulopathy, nutrition
-
puberty
- age at which generative organs become functional and reproduction is possible
- not same as sexual maturity
-
factors influencing onset of puberty
- age: cattle- 6-18mth, sm rum- 6-12mth, horse- 18mth, swine- 6mth
- nutrition- good nut leads to reaching puberty earlier
- season
- climate- tropical temp reaches puberty earlier
- disease- slows growth
-
estrus, estrous, estrual
- estrus- noun, heat
- estrous- adjective, hot
- estrual- adjective
- an estrous female is in estrus.
-
anestrus
- without cyclicity
- period of sexual quiescence- season, pregnancy, lactation, presence of offspring, pathology, stress, age
-
photoperiod
- mediated by pineal gland and its secretion of melatonin
- long light breeder- summer- dec meleatonin- horse
- short light breeder- late summer, early autumn, inc melatonin- sheep, goat
-
temp effects on reproduction
- excessive heat causes inc in early embryonic death and behavioral estrus is shorter
- inc temp= dec DM intake= longer interval post partum anestrus
-
interovulatory intervals
- cow- 21d
- sheep- 17d
- goat- 21d
- mare- 21d
- sow- 21d
-
phases of estrous cycle
- follicular- estrogen
- luteal- progesterone
- anestrus
-
length of estrus
- cow- 12-18hr
- mare- 3-10d
- sow- 48-72hr
- goat- 12-24hr
- sheep- 24-36hr
-
ovulation relative to estrus
- cow- 12-18 hr after end
- mare- 24-48hr before end
- sow- 24-42hr after onset
- goat- 12-24hr after onset
- sheep- towards end
-
diestrus length
- cow- 16d
- mare- 15d
- sow- 14d
- goat- 18d
- sheep-12d
-
signs of estrus in cow
- primary- standing to be mounted
- secondary- mounting others, clear mucus, hyperactivity, bellowing
-
signs of estrus in ewe and doe
- primary- stands for mounting
- secondary- restless, tail switching, seeking male, vocalization
-
signs of estrus in sow
- primary- stand for mounting, response to pressure
- secondary- anorexia, restlessness, salivation, grunting
-
signs of strus in mare
- almost none without male
- tail elevation
- winking of vulva
- posturing
- stands for mounting
-
palpation findings in cow
- estrus- cervix no change, tonic uterus, CL <1cm, follicle 1.5-2.5cm
- diestrus- cervix no change, flaccid uterus, CL 3cm, follicles >1cm
-
palpation findings in mare
- estrus- relaxed cervix, flacid uterus, follicle >30mm
- diestrus- tight cervix, tonic uterus, CL not palpable, follicles <30mm
-
prostaglandin use in cow
- tx btw 5 and 7 d, luteolysis, follicular maturation, estrus, ovulation btw 2 and 5 d after tx
- tx after d 10 more likely to respond, estrus less synchronous
- tx btw d 5 and 10 less likely to responde, more synchronous
- if not working then prob acyclic
- must have normal repro organs, non-preg, regular estrous cycles
- double inj- 11 d apart, estrus 2-5d after inj
- single inj- palpate CL and only tx these
-
progestin use in cow
- artificially prolong estrous cycle and abruptly stop to mimic luteal regression
- norgestomet- implant SQ in ear, inj also
- suppress estrus and ovulation for 9d
- remove implant and estrus follows in 36-60hr
- calf removal for 48hr at time of implant removal
-
Ewe breeding
- induce estrus during anestrous season- expose to 16hr/d of light during late winter and remove 60d before breeding
- introduce ram in late summer- induced ovulation not with estrus, second ovulation is fertile
- melatonin implants
-
progestins in ewe
- norgestomet- half implants, 1/8 inj, remove after 9-14d, estrus in 3d
- oral (MGA), intravaginal (CIDR)
- mimic luteal phase so no LH
-
prostaglandin use in ewe
double inj 9 days apart bc shorter time btw estrous cycles than cow
-
progestin use in goat
implants or intravaginal
-
prostaglandin use in goat
- effective only during normal breeding season
- 2 doses at 10 d interval
-
Mare breeding
expose to 16 hr light per day- start in early Dec bc takes 6 to 8 wks
-
progesterone use in mare
- daily altrenogest for 10-15d to suppress LH
- estrus 2-5d after stop altrenogest
- more successful if mare follicle >20-25mm
- "estrus suppression"
-
domperidone use in mare
one daily results in ovulation 12-22d after tx started
-
induce ovulation in mare
- hCG- 36 to 48 h
- GnRH (desorelin)- 36-40 h
-
prostaglandin use in mare
- Cl must be mature/ >5d post ovulation
- indications- shorter cycle, retained CL, term preg
- lutalyse, estrumate
- 2 inj 14-18 d apart
- use with prog- altrenogest 8-14d then PGF, estrus in 2 to 5d
-
sow breeding
- expose to boar when approaching puberty to simulate follicular growth and reach first estrus sooner
- relocate to breeding pen or mix groups to stimulate follicular growth
- true lactational anestrus- follicular growth at weaning and estrus 4 to 9d after weaning
-
prostaglandin use in sow
CL not responsive until d 12-14 so not useful to synch
-
progestin use in sow
- altrenogest fed for 14-18d
- withdraw and estrus in 2d
- not approved in US
-
-
progestins
- inhibit LH
- block ovulation
- inhibit behavioral estrus
-
hCG/LH
- stimulate follicular growth
- oocyte maturation
-
FSH/eCG
- stimulate follicular recruitment and growth
- except in mare
-
estrogens
- stimulate behavioral estrus
- luteolytic in cow
- luteotropic in sow (CL will persist longer)
- supress follicular growth- mare
-
advantages of AI
- utilize superior sires
- easy to ship semen
- males more carefully selected
- danger and expense of maintaining male is eliminated
- less chance of venereal dz
-
disadvantages of AI
- trained techs required
- rapid spread of genetic abnormalities
- narrowing of genetic base
-
semen storage
- frozen in liquid nitrogen
- tank should contain several inches of nitrogen
- canisters never raised above neck of refigerator
- select semen package in 9-15 sec
-
bovine collection of semen
-
bovine AI insemination
semen deposited in uterine body
-
sheep AI
- not widely used
- laparoscopic with smen deposited into uterine lumen
- male- small vol
-
goat AI
- restrain doe with hindquarters elevated
- male- small vol
-
horse semen packaging
- fresh- mare inseminated soon after collection
- chilled- extended, inseminated within 24 hrs
- frozen- inseminate within 6-8hrs of ovulation
-
horse collection of semen and insemination
- artificial vagina- mare in estrus, phantom
- extenders- 4:1
- dose- 500,000,000 progressively motile
- want to inseminate 48hr prior to ovulation so AI on alternate days during estrus- in uterine body
-
porcine semen collection and AI
- fresh or frozen
- phantom, gloved hand, AV
- must have min vol of 50 ml with 1 billion motile
- inseminate 24-30hr after onset estrus
- pipettes with counterclockwise spiral for sow cervix
-
bovine recognition of pregnancy
- trophoblast elongates and fills both horns
- 15-17d after mating
- luteotrophic substance released by embryo to prevent PGF and CL is maintained
-
small rum recognition of pregnancy
day 15
-
equine recognition of pregnancy
- embryo mobile thru both horns to block PGF
- fixation day 15-17
- twins must be reduced prior to day 40
-
porcine recognition of prenancy
- day 13
- estradiol produced by blastocyst suspends luteolysis
- PGF produced but sequestered in uterine horn
- at least 4 live embryos are required to maintain pregnancy until day 40
- elongation of trophoblast
-
length of pregnancy
- cow: 273-296 d (fetal giantism in some breeds)
- ewe: 140-155 d (Veratrum californicum on 14th d results in cyclopse and prolong gest.)
- doe: 148-156
- mare: 340-342 d (prolonged gest. normal)
- sow: 114 d
-
CL during pregnancy
- cow: CL fxn to provide prog, prior to day 200 abort with PGF, after use dex and PGF to abort
- ewe: CL until day 50 then placenta secretes prog
- doe: CL dependent to supply prog
- mare: CL provides prog initially, supp CL after day 40, fetal prog by day 100
- sow: CL dependent for prog
-
pregnancy diagnosis by rectal palpation of bovine
- amniotic vesicle: 30-65d
- fetal membrane slip: 35-90d
- fetus: 65-70d
- placentomes: 85d
- contributory signs- fremitus of middle uterine artery
-
staging bovine pregnancy
- mouse- 2mth
- rat- 3mth
- small cat- 4mth
- large cat- 5mth
- beagle- 6mth
-
lab methods of preg diagnosis in bovine
low prog at 20-24d after breeding in cow returing to estrus and not preg
-
electronic method of preg diagnosis in bovine
ultrasound- day 25, fetal sexing 55-75d
-
pregnanacy diagnosis in ewe
- return to estrus
- abdominal ballottment- d 90-130
- ultrasound- d 40, real time
- doppler- detect placental blood flow/heartbeat
- rads
-
pregnancy diagnosis in doe
- return to estrus in 21 d
- ab ballottment
- real time ultrasound
- doppler
- rads
- elevated prog at d 20 suggests preg
- detect estrone sulfate in blood (made by fetus)
-
preganacy diagnosis via rectal palpation of mare
- day 17-21: inc uterine tone, cervix firm
- day 35: fetal bulge 3-4cm
- day 42: fetal bulge 5-7cm
- day 60: fetal bulge 8-10cm (football size)
- day 90: soccer ball size
-
lab methods of preg diagnosis in mare
- endometrial cups day 40-150, highest eCG day 60- persist even if aborted
- high estrogen if preg after day 75
-
electronic preg diagnosis in mare
real time ultrasound- examine d 16 so can rebreed if not preg
-
electronic method of preg diagnosis in sow
- amplitude depth- d 30 to 45, tissue density and fluid density
- real time ultrasound
-
post partum re-breeding of cow
best results at 40-60d
-
cystic ovarian dz in cow (COD)
- due to failure of ovulation
- >25m
- thin wall
- single or multiple
- one or both varies
- luteinized cysts are thicker walled
- ?inadequate LH, dysfxn, inc stress, hereditary
- anestrous mostly, can have frequent estrus
- tx- spontaneous regression, LH/hCG, GnRH (try 1st)
- estrus 3 wk after tx or give PGF 9 days later to reduce from 3wk to 12d
-
freemartin
- co-twin to a male
- anastomosis btw placental vessels
- underdev
- no communication btw vagina and uterus
- karyotype, rectal palpation, 90% born co-twin
-
ovarian hypoplasia
small repro tract
-
segmental aplasia in cow
- white heifer dz
- cranial genital tract normal
- caudal uterine horns aplastic
- no drainage thru cervix so secretions accumulate in horns
- no signs of pregnancy
-
-
hydrometra in doe
- clear fluid in uterus
- persistant CL
- expelled at d 50- cloudburst
- tx- PGF
-
prolonged estrus in mare
- common in spring
- may respond to male for 30d
-
prolonged diestrus in mare
- persistant CL secretes prog
- tx- pGF
-
neoplasia in mare affecting repro
- granulaosa-thecal cell tumor
- secretes inhibin adn testosterone- no FSH and gt ovary atrophy
- benign
- abnormal estrous cycle, stallion like behavior
-
endometrial cysts in mare
- block embryo migration
- older mares
- ddx: amniotic vessicle (grows faster than cyst)
-
vulvar abnormalities in mare
- failure of vulva to close leads to pneumovagina and infertility
- vaginitis, cervicitis, andometritis
- "wind sucking"
- tx- caslick
-
sow repro problem
- seasonal infertility- summer anestrus
- 5-10% abnormal tracts- segmental aplasia, abnormal vulva
- cystic ovaries
- post partum anestrus for gilts
- anestrus if housed alone
-
Trichomoniasis
- early abortions (17d- 5mth)
- repeat breeding
- long calving season
- no signs in bull- lesionless carrier (older bulls more likely affected bc epithelial crypts in prepuce)
- dx- culture of vaginal mucus/preputial smegma (diamond's media)
- survives freezing
- female infected at breeding
- vacc prior to breeding
-
Campylobacteriosis
- C. fetus ss. venerealis
- early abortions (4-7mth)
- repeat breeding
- long claving season
- dx- culture aborted fetus lung, liver, abomasal content- culture female tract- culture preputial smegma (clarks media)
- some chronic carrier cows
- bulls- leasionless carrier (older bulls more likely affected)
- vacc prior to breeding
-
Ulcerative dermatosis
- pizzle rot in sm rum
- 1. ulcers around mouth, nose and legs
- 2. venereal dz
- parapoxvirus
- ulcers covered by scabs
- ddx: contagious ecthyma (orf)
-
Contagious Equine Metritis (CEM)
- reportable in US
- rapidly spreading venereal dz
- Taylorella equigenitalis- gram neg
- copious vaginal discharge within a few days after breeding
- dec fertility
- stallion- lesionless carrier
- dx- culture (Amies charcoal)
- tx- Ab uterine infusion, clitorectomy, topical Ab on penis
-
Coital exanthema
- equine herpesvirus 3
- venereal
- no abortion
- no affect on fertility
- small raised papules/pustules/ulcers on vestibular mucosa, vulva, and perineum of mares or penis of stallions
- spontaneously heal in 2 wk
- may depress libido
-
pseudomonas and klebsiella
- P- in water
- K- in soil
- usually not pathogenic forms
- culture
-
Equine Viral Arteritis (EVA)
- systmeic illenss- fever, leukopenia, edema, stiffness, nasal discharge, skin rash, abortion
- high percent Standardbreds
- stallions can be chronic shedders
- dx- serology, culture semen, test breeding
- vacc- vacc induced Ab
-
Brucellosis
- purulent metritis and cervicitis in sows
- early embryonic death
- orchitis/epididymitis in boars
- Brucella suis
- dx- serology, culture
- tx- slaughter
-
nonvenereal infectious infertility
- most ascending
- vaginitis, cervicitis, retained placenta, trauma from dystocia
- dx- culture, cytology, biopsy, ultrasound
- tx- Ab, lavage, prostaglandins
-
bovine nonvenereal infectious infertility causes
- Actinomyces pyogens
- tx- penicillin
-
Equine nonvenereal infectious infertility causes
- Strep. zooemidemicus
- E. coli
- Pseudomonas
- Klebsiella
- Candida
- Aspergillus
- tx- penicillin
-
Porcine Nonvenereal infectious infertility
- SMEDI (porcine parvo, PRRS, psuedorabies)
- lepto
- erysipelothrix
- toxoplasmosis
- actinomyces
- aspergillus
- salmonella
-
indications for eval of male
- prior to sale
- prior to breeding
- id and diagnose infertility
- large testes and >70% normal sperm results in preg rates inc >7%
-
Breeding Soundness Exam
- Hx
- ID
- PE
- Genital exam
- observe sexual behavior if possible
- semen collection
- semen eval
- interpretation of findins
-
Bull semen eval- motility
- very good- vigorous swirls
- good- slow swirls and eddies
- fair- no waves of mevement, cells moving
- poor- very slow, erratic motion
-
Bull semen eval- morphology
- primary- major- serious effects on fertility
- secondary- minor- less likely to affect fertility
- tertiary- iatrogenic
-
Bull minimum scrotal circumference
-
Bull guidelines for progressive motlity
- very good >70%
- good 50-69%
- fair 30-49%
- poor <30%
-
Min guidelines for bull BSE
- min 30 cm scrotal circumference
- fair gross motility
- min 30% individual motility
- 70%normal morphology
-
Satisfactory Potential Breeder
- bull
- equals or surpasses all min thresholds
- no evidence of breeding related abnormalities
-
Unsatisfactory Potential Breeder
- bull
- below one or more min thresholds
- genetic faults
- irreversible physical abnormalities
-
Classified Deferred
- bull
- does not fit satisfactory or unsatisfactory categories
- likely to show improvement (immature yearling, unobtaineable ejaculate, treatable physical defect)
- re-examine later
-
Buck semen eval
- vol- 0.5-1ml
- gross motility- rapidly swirling
- individual motility >75%
- morphology >75%
-
Ram PE for BSE
- BCS 1 or2- questionable
- BCS 3 or 4- satisfactory
- BCS 5- questionable
- no abnormalities (post-legged, foot rot, foot abscess)
-
Ram BSE classifications
- excellent- SC >35cm, otility >50%, normal 90%, can breed at least 100 ewes in 60d
- satisfactory- SC>33cm, motility >30%, normal >70%, can breed at least 50 ewes in 60d
- questionable
- unsatisfactory
- cull, tx, or retest Q & U
-
Stallion BSE
- min 8cm scrotal width
- achieve preg rate >75%
-
Stallion BSE classification
- satisfactory- no significant abnormalities
- two ejaculates, 1 hr part- 1 billion PMMN sperm in 2nd, 60% progressive motility and normal morphology
- questionable- borderline in 2 or more criteria
- unsatisfactory- very low in 2 or more criteria, physical shortcomings, heritable defects
-
Boar PE for BSE
- lameness is major cause of dec breeding performance
- check preputial diverticulum
-
Boar semen eval
- largest semen vol of all species
- motility 70-90%
- morphology >85%
-
embryonic mortality
death of conceptus before completion of organogenesis
-
fetal mortality
- in utero death after organogenesis
- before expulsion or extraction from dam
-
neonatal mortality
death within 28 d of birth
-
perinatal mortality
includes fetal and neonatal deaths
-
abortion
expulsion of conceptus incapable of independent life
-
premature delivery
expulsion of viable fetus before full term
-
dysmaturity
neonate small and immature for gestational age
-
congenital
defects or infections present at birth or abortion
-
major causes of perinatal mortality in calves
- dairy- dystocia, diarrhea, pneumonia
- beef- hypoxia, injury
-
major causes of perinatal mortality in piglets
- mortality inc as litter size inc and birth wt dec
- env and nutritional
-
major causes of perinatal mortality in lambs
env and nutrition
-
major causes of perinatal mortality in foals
- 2% of Thoroughbreds
- spesis
-
incidence of embryonic mortality
- high in domestic animals
- embryo reabsorbed so rarely observed
-
abortion stats
- early abortions usually not observed
- fetus dies in utero and expelled within 24-72h with varying degrees of autolysis (6-12h cloudy cornea, 24h soft kidney, 36-96h color changes in skin)
- <50% diagnosed definitively
-
Placentitis
- most common lesion with infectious abortion
- acute- invade placentomes- hyperemia- necrosis- fetal invasion
- chronic- periphery of placentome- thickening of chorioallantois- separation of affected cotyledons
-
placental invasion route
- hematogenous- brucellosis, listeria, lepto
- extension from uterus- toxoplasmosis, campylobacter fetus, actinomyces pyogens
- ascending from vagina
-
fetal invasion
- directly- umbilical vein
- indirectly- amniotic fluid (inhalation, ingestion, skin)
-
common signs of inrauterine infection
- edema
- fetal autolysis
- but these are non-specific
-
microscopic lesions associated with intrauterine infection
fetal liver, lung, intestine, placenta
-
diagnosing abortion
- all considered infectious until proven otherwise
- tx as herd problem
- separate leak proof containers
- chilled not frozen
- submit intact abomasum, liver, lung, kidney, spleen, adrenal glands, placenta
- organs in 10% formalin
- swabs less desirable
- badly decomposed- brain contents, uterine swabs
- serology- least informative, serum from dam at abortion and 2-3wks after (compare with histo, micro, and cytologic data)
-
Leptospirosis abortions in pig
- most common
- L. pomona
- 2-3 wks until term
- infection persists for 6mth-1yr
- dx- not all fetuses have organism, sow Ab present at abortion
-
Brucellosis abortions in pig
- Brucella suis
- venereal dz (unlike cattle which is via ingestion)
- boars- infected for life
- no vacc
- abortion at all stages
- zoonotic
-
viral infertility and abortion on pigs
- PPV
- porcine enterovirus
- psuedorabies virus
- hog cholera
- PPRS
- virus crosses placenta and kills conceptus before maternal recognition (d 11-12)
- <35 d- skeletal mineralization so irregular return to heat
- >35 d- fetal mummification, all die or if 2 or more survive then normal gestation
- >70 d- fetal Ab, may survive, born weak
-
IBR
- bovine abortion
- abortion storms
- major viral cause in US
- fetal lesions- inclusion bodies
-
Leptospirosis
- bovine abortion
- abortion in last 2 mths
- dx- lepto in placenta, fetus, cow's urine
-
Brucellosis
- bovine abortion
- retained fetal membranes (RFM)- discharge highly infectious
-
Campylobacter fetus
- ovine abortion
- major bacterial cause
-
EAE- Chlamydophila abortus
- ovine abortion
- late abortion
-
Toxoplasmosis- Toxoplasma gondii
- ovine abortion
- placental lesions- specific cotyledonitis "pepperoni pizza placenta"
-
Rhinopneumonitis
- EHV-1
- equine abortion
- most common infectious late cause
- last trimester
- highly contagious
- fetal lesion- fresh fetus, hepatic intranuclear inclusion bodies
-
Streptococcus zooepidemicus
- equine abortion
- most common bacterial cause
-
signs of approaching parturition
- segregation
- loss of appestite
- anxiety
- restlessness
-
signs of approaching parturition in a cow
- udder dev- heifers at 4mth, pluriparous at 2-3wks
- relaxation of pelvic lig- raised tail head
- flaccid edematous vulva
- tenacious mucus discharge- cervical plug softens at 7mth
- anorexia and restlessness- few hr prior to calving
- similar in ewes and does- less udder dev
-
signs of approaching parturition in mare
- udder dev- primiparous at 3-6wk, pluriparous at 2-4 wk, waxing of colostrum at 24-48hr
- relaxation of pelvic lig
- vulva becomes edematous
- most foal at night
- mare able to exercise come control- disturbances may delay
-
signs of approaching parturition in sow
- mammary glands- firm 1-3d prior, secretions 48h prior
- nest building
- vulvar swelling- 3-4d prior
-
First stage of labor
- relaxation of cervix and myometrial contractions
- cow 6-12hr
- ewe and doe 6-12hr
- mare 1-4hr
- sow 2-12hr
-
Second stage of labor
- expulsion of fetus
- rupture of chrioallantois
- uterine contractions inc
- fetus enters birth canal- ferguson's reflex
- cow: primiparous 4hr, pluriparous 1-2hr
- ewe and doe: 0.5-2hr, twins longer
- mare: 5-40 min, intact amnion, mare remains recumbent 15-30min
- sow: 30min-10hr, longest interval btw 1&2 and last
-
Third stage of labor
- expulsion of fetal membranes
- cow 0.5-8hr, pathologic 12hr, uterine involution 60d
- ewe and doe 0.5-4hr, uterine involution 30d
- sow 2-3 intervals during parturition
- mare 0.5-3hr, pathologic after 4hr, uterine involution 14d
-
dystocia
- maternal 25%
- fetal 75%
- more common in primipara
-
hereditary causes of dystocia
- rectovaginal constriction
- multiple fetuses
- prolonged gestation
- hydrops
- hydrocephalus
- double muscling
-
nutritional and management causes of dystocia
- small dam
- overnutrition- fat deposits
- lack of exercise- uterine inertia
-
causes of dystocia
- hereditary
- uterine torsion
- uterine inertia
- trauma
- nutrition and management
- fetal monsters
- fetopelvic disproportion
-
Uterine inertia
- primary- cow and sow, lack of oxytocin or response by uterus
- secondary- all species, peritonitis, sepsis, complication of prolonged dystocia
-
clinical approach to dystocia
- Hx- breeding date, parity, duration of labor
- unusual symptoms
- restraint
- general exam of dam
-
fetal survival during dystocia
- cow 8-12hr after onset stage 2
- ewe and doe 8-12hr after onset stage 2, poor dam survival
- mare 30-40min after onset stage 2, mare survival poor
- sow 1st fetus dies after 6hr, all dead after 24-36hr
-
repro exam of fetus during dystocia
- withdrawal reflex
- corneal reflex
- suckling reflex
- anal sphincter reflex
- pulse
- cloudy cornea 8-12h
- hair comes of 24-48hr
- emphysema 24-48h
-
presentation during dystocia
- relation of spinal axis of fetus to dam
- longitudinal (cranial/caudal) vs transverse (dorsal/ventral)
-
position
- relation of dorsum of fetus to quadrants of maternal pelvis
- dorsosacral- ideal
- dorsopubic
- dorsoiliac
-
posture
- relation of extremities (head, neck, limbs) to fetus
- flexed or extended
-
how to tell front limb from hind limb
- forelimb- three joints
- hindlimb- two joints
-
mutation
operations that retuen fetus to normal PPP
-
repulsion
pushing fetus out of pelvis or birth canal
-
rotation
turning fetus on its long axis
-
version
turning fetus on its transverse axis
-
forced extraction
withdrawal of fetus by outside force or traction
-
fetotomy
operations to reduce the size of the fetus
-
shistosomas reflexus
fetal monster with severe ventral curvature of spine and incomplete closure of abdominal wall
-
epidural during dystocia
use judiciously bc interferes with dams ability to help expel fetus
-
anterior presentation of cow
- commonly mishandled with too much traction
- loop chain above fetlock and around pastern, dorsal surface
- extraction possible if extend 10cm beyond vulva
- put cow in right lateral
- only pulls when cow strains
- rotate fetus 90 degrees when thorax is extracted
-
posterior presentation of cow
- fetus can die quickly
- cow in right lateral
- rotate fetus 90 degrees immediately
- hips delivered then rotate back
-
true breech
- posterior longitudinal
- dorsosacral
- hips flexed
- limbs extended under abdomen
- inadequate dilation of birth canal
-
fetotomy contraindications
- inadequate size of birth canal
- severly emphysematous fetus
- uterine rupture
-
induced parturition in cow, sheep, goat
- limited indications
- corticosteroids and PGF
-
induced parturition in mare
- only for medical condition like premature placental separation
- rupture of prepubic tendon
- attended foaling required (prevent nursing)
- not for convenience
- not for prolonged gestation
- 330d
- colostrum in udder
- relaxation of lig
- cervical relaxation
- oxytocin (not labeled dose)
-
induced parturition in sow
- management tool
- PGF on d 111 or 112
- oxytocin 20hr after PGF
-
neonatal care
- colostrum intake 1-2h after birth
- IgG dec by 33% in 6hr, dec by 66% in 24hr
- calves ingesting E. coli prior to colostrum closes gut and prevents absorption of Abs
- should consume 6-10% of body wt in first 24hrs
-
first postpartum ovulation in dairy cow
- 20 d postpartum
- silent estrus bc no prog
- delay of ovulation bc neg energy balance
-
first post partum ovulation in beef cow
- 40-60d post partum
- nursing blocks LH
- wean at 205d
-
first post partum ovulation in ewe and doe
- 6mth post partum
- seasonal influence- anestrus in spring
-
first post partum ovulation in mare
- foal heat 5-12d post partum
- best results if over 10d PP bc uterine involution takes 10-14d
-
first post partum ovulation in sows
- true lactational anestrus
- behavioral estrus 1-5d post partum but no ovulation
- ovulation interval inversely proportional to length of lactation
- group weaning to synch
- post weaning anestrus in summer
-
retained placenta in cow
- 5-10% in dairy
- 1% in beef
- twins, short/long gestation, abortion after 5mth, dystocia, vit deficiency, uterine inertia, hot weather
- retained in gravid uterine horn
- malodorous
- expelled after necrosis and sloughing of caruncles in 4-10d
- tx- no manual removal, oxytocin if <24hr or PGF?, no tx and just monitor, Ab
- prognosis good without metritis
-
retained placenta in ewe and doe
- uncommon
- dystocia, retained fetus, Se deficiency
- septic metritis
- tx- oxytocin, Ab, tetnus, supportive
-
retained placenta in mare
- tip of nongravid horn
- dystocia, cesarean, uterine inertia
- septic metritis
- tx- no manual removal, oxytocin, Ab, NSAIDs, tetanus, PGF, burns technique
- prognosis fair to good without complications
-
retained placenta in sow
- uncommon
- dystocia
- tx- oxytocin, Ab, supportive
-
postpartum uterine infections in cow
Actinomyces pyogens- most common, white pus, unsanitary env, tx penicillin and PGF and Ab and lavage
-
traumatic injuries postpartum
- forced extraction
- manual placental removal
- sontaneous resolution, tx oxytocin
- middle uterine artery rupture
- laceration
- hematomas
- paralysis
- uterine rupture
-
uterine prolapse
- most common in cow
- clean, elevate pelvic brim
- tx- reduce edema, replace bottom and sides first, oxytocin, amputation
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