P.Kinetics

Refers to the relative amount of drug that reaches the systemic circulation

A measure of acidity

The ratio of drug concentration in 2 phases separated by a semipermeable membrane

Refers to a more comprehensive concept that includes the drug formulation and the dynamic interactions among the drug, its formulation matrix, its container, and the patient

Substance that may exist in more than one crystalline form or amorphous form

These are addition compounds of drug and water

The equation that best describe the overall rate of drug dissolution

Which type of formulation may accidentally release active drug from a dosage form

Ability of chemical compound to exist as optically active sterioisomers or enantiomers

The dissociation constant for weak base which ionizes according to the equation: HB + H₂O = H₂O + B is equal to ______

Drugs administered by intrathecal route are absorbed in the ____

Is the delivery of the active ingredient from a dosage form into a solution

The process by which a drug enters the bloodstream

Those multiple source drug products that contain identical amount of the identical active ingredients in identical dosage form are called ____

Are additives which are necessary in formulating a dosage form from a drug

The dose size required to maintain the effectiveness or therapeutic concentration according to the dosage regimen

The ratio of drug concentration in the lipid phase over the concentration of the drug in the aqueous phase

The route of administration that gives the fastest onset of pharmacologic effect is ____

The rapid degradation of a drug by liver enzymes in a liver prior to its absorption

The mathematical equation used in determining the passage of drug across cell membrane

These are addition compounds of drug and organic solvents

The extent or fraction of drug absorbed upon extravascular administration in comparison to the standard with similar dose size administered

Pharmacokinetic parameter that gives useful information about the amount of drug systemically absorbed is ____

The route of drug administration that provides complete (100%) bioavailability is ____

The extent of ionization of a weak electrolyte drug is dependent on ____ and ____

The process with the slowest rate constant in a system of simultaneous kinetic process

The lipid phases employed in the determination of apparent partition coefficient include ____

The ions of added electrolyte require water for hydration reducing the amount of water available for the solution of the non-electrolyte is the phenomenon of ____

An agent that takes up another substance into its intraspace structure is called ____

The property of absorbing moisture from the atmosphere

Method that includes sampling of blood, spinal fluid, tissue biopsy, or any biological material that requires parenteral or surgical intervention in the patient is ____

The prerequisite of absorption at the absorption site is ____

Which of the following peroral dosage forms is likely to exhibit the shortest lag time

The rectal route of administration may be preferred over the peroral route for some systemic-acting drugs because

Differences in bioavailability are most frequently observe with drugs administered by which of the ff routes?

Which of the following series in kinetic processes may be the rate-limiting step for drugs that are poorly soluble in aqueous media

Use of free acid or free base form of the drug ____ the rate of drug dissolution from a tablet (increases, decreases)

Which of the following is the first process that must occur before a drug can become available for GI absorption from a tablet dosage form?

Which of the ff types of dosage form does not require dissolution prior to absorption?

Given the pKa value of a drug, the theoretical equilibium ratio of weak acids can be calculated as

APC can be calculated using the following formula

Are complexes that typically involve a ring-like structure formed by the interaction between a partial ring of atoms and a metal

Equal mixtures of dextrorotatory and levorotatory enantiomers are called

Different polymorphs of the same drug exhibit differences in ____

Using the equation dc/dt = DA / h * (Cs-C), which factor/s is/are inversely proportional to the rate of dissolution in tle lipid membrane of lipoid soluble unionize substances?

The smallest particle size approved by the FDA is ____

What factors may influence drug liberation process?

Substances that exist as ions and rapidly dissociates in water are called ____

Aqueous phase employed in the determination of APC ____

What are the characteristic of weak electrolytes?