Antianginal and Anti-hypertension

  1. Nitroglycerine
    • Causes smooth muscle dilation
    • Taken under tongue to avoid 1st pass effect
  2. Steps for smooth muscle contraction
    • Nitrates>Nitrites>Nitric oxide>GMP>Myosin light chain
    • All are increasesd
  3. Treatment Hypertension
    • ACE inhibitors
    • Inhibit renin and angiotensin II
    • Increase sypathetic tone by using B blockers
    • Diuretics
  4. Thiazide
    • Direct arteriole effect, removes Na and H2O in order to lower blood volume
    • Diruetic
    • Drug of choice
  5. Bradykinin
    • Causes dry cough
    • Broken down by ACE
Author
Kate718
ID
98985
Card Set
Antianginal and Anti-hypertension
Description
Chapter 19
Updated