1. Most common translocation associated with NHL
    Chromosomes 14 and 18
  2. Most common translocation associated with mantle cell lymphoma
    Chromosomes 11 and 14 - results in overexpression of cyclin D1
  3. Translocation associated with high-grade small noncleaved lymphomas (Burkitt & non-Burkitt)
    Chromosome 8 - involves c-myc dysregulation
  4. Abnormalities associated with anaplastic large cell lymphoma
    Chromosome 2 & 5 translocation (between NPM and ALK genes. CD30+ - allows for differentiation from carcinoma
  5. Translocation associated with MALT lymphomas
    Chromosomes 11 & 18. Often associated with H. pylori infection also
  6. Lymphomas associated with Epstein-Barr
    Burkitt lymphoma; Hodgkin disease; lymphomas in immunocompromised patients
  7. Lymphomas associated with HTLV-1
    Adult T-cell leukemia or lymphoma. Endemic in certain areas of Japan & the Caribbean
  8. Lymphomas associated with HCV
    Clonal B cell expansions & certain subtypes of NHL (especially in the setting of mixed cryoglobinuria)
  9. Ann Arbor stage I
    Involvement of a single lymph node region
  10. Ann Arbor stage II
    Involvement of 2+ lymph node regions on the same side of the diaphragm
  11. Ann Arbor stage III
    Involvement of lymph node regions on both sides of the diaphragem
  12. Ann Arbor stage IV
    Multifocal involvement of 1+ extralymphatic sites with or without associated lymph nodes or isolated extralymphatic organ involvement with distant nodal involvement
  13. IPI for NHL
    Negative prognostic indicators - APLES: Age>60; Performance status 2-4; LDH elevated; Stage (Ann Arbor) III-IV. 0-1 point = low risk; 2 = low intermediate; 3 = high intermediate; 4-5 = high
Card Set