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HMG-CoA Reductase Inhibitors
- Rosuvastatin (Crestor)
- Atorvastatin (Lipitor)
- Pitavistatin (Livalo)
- Simvastatin (Zocor)
- Pravastatin (Pravachol)
- Lovastatin (Mevacor, Altoprev)
- Fluvastatin (Lescol, Lescol XL)
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Cholesterol Absorption Inhibitor
Ezetimibe (Zetia)
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Fibric Acid Derivatives
- Gemfibrozil (Lopid)
- Fenofibrate (Fenoglide, Lipofen, Lofibra Tabs, Tricor, Triglide)
- Fenofibrate - micronized (Antara, Lofibra Caps)
- Fenofibric Acid (Trilipix)
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Bile Acid Sequestrant
- Colestipol (Colestid)
- Colesevelam (Welchol)
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Bumblebee Tuna
Omega-3 Fatty Acids (Lovaza)
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Rosuvastatin (Crestor)
- Dosing Range: 5-40 mg
- Frequency: 1
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Atorvastatin (Lipitor)
- Dosing Range: 10-80 mg
- Frequency: 1
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Pitavistatin (Livalo)
- Dosing Range: 1-4 mg
- Frequency: 1
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Simvastatin (Zocor)
- Dosing: 5-80 mg
- Frequency: 1
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Pravastatin (Pravachol)
- Dosing Range: 10-80 mg
- Frequency: 1
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Lovastatin (Mevacor)
- Dosing Range: 10-80 mg
- Frequency: 1-2
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Lovastatin (Altoprev)
- Dosing Range: 10-60 mg
- Frequency: 1
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Fluvastatin (Lescol)
- Dosing Range: 20-80 mg
- Frequency: 1-2
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Fluvastatin (Lescol XL)
- Dosing Range: 80 mg
- Frequency: 1
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Ezetimibe (Zetia)
- Dosing Range: 10 mg
- Frequency: 1
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Niacin (Niaspan)
- Dosing Range: 500-2,000 mg
- Frequency: 1
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Gemfibrozil (Lopid)
- Dosing Range: 1200 mg
- Frequency: 2
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Fenofibrate (Fenoglide)
- Dosing Range: 40-120 mg
- Frequency: 1
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Fenofibrate (Lipofen)
- Dosing Range: 50-150 mg
- Frequency: 1
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Fenofibrate (Lofibra Tabs)
- Dosing Range: 54-160 mg
- Frequency: 1
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Fenofibrate (Tricor)
- Dosing Range: 48-145 mg
- Frequency: 1
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Fenofibrate (Triglide)
- Dosing Range: 50-160 mg
- Frequency: 1
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Fenofibrate-micronized (Antara)
Dosing Range: 43-130 mg
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Fenofibrate-micronized (Lofibra Caps)
- Dosing Range: 67-200 mg
- Therapy: 1
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Fenofibric Acid (Trilipix)
- Dosing Range: 45-135 mg
- Frequency: 1
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Colestipol (Colestid)
- Dosing Range: 2-16 mg
- Frequency: 1-2
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Colesevelam (Welchol)
- Dosing Range: 2500-4375 mg
- Frequency: 1
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Omega-3 Fatty Acids (Lovaza)
- Dosing Range: 4 grams
- Frequency: 1-2
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What is the MOA for Statins (HMG-CoA Reductase Inhibitors)?
Inhibits the rate-limiting step of de novo synthesis of cholesterol.
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What are some adverse effects of statins/HMG-CoA Reductase Inhibitors?
- myalgia
- LFT elevation
- CK elevation
- hepatic failure
- rhabdomyolysis
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How do you monitor statins?
LFTs, S/Sx (signs & symptoms) of myalgia
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What is the MOA of Cholesterol Absorption Inhibitors?
Inhibits cholesterol absorption at the brush border in the small intestine.
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What are some adverse effects of Cholesterol Absorption Inhibitors?
- hepatitis
- cholecystitis
- cholelithasis
- abdominal pain
- diarrhea
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How do you monitor Cholesterol Absorption Inhibitors?
Nothing listed on drug chart
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What is the MOA of Niacin?
- Enhances lipoprotein lipase activity
- Inhibits lipolysis in adipose tissue
- Decreases VLDL production
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What are some adverse effects of Niacin?
- flushing
- abdominal pain
- LFT elevation
- N/V
- hepatic failure
- hyperglycemia
- hyperuricemia
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How do you monitor Niacin?
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What is the MOA of Fibric Acid Derivatives?
- Inhibits lipolysis in adipose tissue
- Decreases production and increases clearance of apoB
- Enhances lipoprotein lipase activity
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What are some adverse effects of Fibric Acid Derivatives?
- dyspepsia
- abdominal pain
- N/V
- diarrhea
- elevated LFTs
- cholelithiasis
- myopathy
- thrombocytopenia
- anemiaa
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How do you monitor Fibric Acid Derivatives?
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What is the MOA of Bile Acid Sequestrants?
Binds intestinal bile acids preventing enterohepatic recirculation.
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What are some adverse effects of Bile Acid Sequestrants?
- esophageal obstruction
- bowel obstruction
- fecal impaction
- dysphagia
- constipation
- dyspepsia
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How do you monitor Bile Acid Sequestrants?
Nothing listed on Drug Chart
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What is the MOA of Omega-3 Fatty Acids?
Decreases hepatic triglyceride synthesis.
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What are some adverse effects of Omega-3 Fatty Acids?
- anaphylaxis
- dyspepsia
- eructation
- elevated LFTs
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How do you monitor Omega-3 Fatty Acids?
LFTs
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