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What is biopharmaceutics?
the study of the physical and chemical properties of a drug and its dosage form, including as related to the:
- onset of drug action
- duration of drug action
- intensity of drug action
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What three main characteristics of drugs does biopharmaceutics deal with?
Biopharmaceutics deals with three main characteristics of drugs:
- 1) physicochemical properties of drugs (e.g., weak acid, weak base, lipophilic, etc.)
- 2) drug formulation (e.g., extended release capsule, oral solution, suspension for IM injection, etc.)
- 3) route by which the drug is administered (e.g., oral, intravenous, rectal, etc.)
Biopharmaceutics is the study of the relationship of these three characteristics with regard to drug delivery and absorption.
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Why is biopharmaceutics important?
Biopharmaceutics will determine whether the drug is:
- effective
- ineffective
- toxic
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What is pharmacokinetics?
- Pharmacokinetics is concerned with four main parameters that control the fate of a drug following administration:
- 1) Absorption
- 2) Distribution
- 3) Metabolism
- 4) Excretion
These properties are also known as ADME for short.
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What is the difference between pharmacokinetics and pharmacodynamics?
Pharmacokinetics is how the body affects the drug
vs.
Pharacodynamics is how the drug affects the body (drug-receptor binding, occupancy-coupling pathways, etc.)
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