Psychiatric - Schizophrenia Antipsychotics

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What are the Characteristic symptoms of a schizophrenic?
- Hallucinations
- Delusions
- Disorganized Speech
- Grossly disorganized or catatonic behaviorNegative symptoms
What drugs are used to treat schizophrenia?
- 1st generation antipsychotics (FGAs or neuroleptics)
- 2nd generation antipsychotics (SGAs or atypicals)
Which FGAs (neuroleptics)are used to treat schizophrenia?
- chlorpromazine (Thorazine)
- thioridazine (Mellaril)
- haloperidol (Haldol)
- perphenazine (Trilafon)
- fluphenazine (Prolixin)
What are the advantages of FGAs (neuroleptics)?
- cheap
- effective for positive sx (perphenazine was 2nd best in CATIE trial)
What are the disadvantages of FGAs (neuroleptics)?
- MANY SE!
- failure to change insight or judgment
- lack of efficacy in 20-30% of pts
- may worsen negative sx
- DI with drugs that affect gastric pH
What are the side effects of FGAs (neuroleptics)?
- EPSE
- prolactin elevation
- sexual dysfx
- anticholinergic effects
- sedation
- wt gain
- dizziness
- orthostatic hypotension
Which SGAs (atypicals) are used to treat schizophrenia?
- clozapine (Clozaril)
- risperidone (Risperdal)
- paliperidone (Invega)
- olanzapine (Zyprexa)
- quetiapine (Seroquel)
- ziprasidone (Geodon)
- aripiprazole (Abilify)
- iloperidone (Fanapt)
- asenapine (Saphris)
How do most of the SGAs (atypicals) work?
- serotonin-dopamine antagonism
- (SDA more 5-HT2 than D2)
What is the only drug succussfully used to treat pts refractory to FGAs?

clozapine (Clozaril)
Which SGAs are better than FGAs for depressive-type sx seen in schizophrenia?
- aripiprazole (Abilify)
- quetiapine (Seroquel)

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Psychiatric - Schizophrenia Antipsychotics

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Psychiatric - Schizophrenia Antipsychotics

Updated

2011-08-23T04:07:58Z

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