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What occurs during Perfusions Injury?
- Ca influx
- Reactive O2
- Cytokines
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What occurs during Free Radical Injury?
- Lipid Per-Oxidation of Membrane
- DNA Lesions
- Cross Linking of Proteins
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In which organs are the First manifestations of Acute Cellular Swelling (6):
- Liver
- Kidney
- Muscle
- Glandular Tissues
- Glial Cell of Brain
- Adrenals
- = Pale, Turgor & Heavy
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What is the micro appearance during acute cellular swelling?
- Ground-Glass Appearance in Cytoplasm
- Small Vacuoles
- Nuclear Swelling
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What are the nuclear changes that occur with necrosis?
- Pyknosis
- Karyorrhexis
- Karyolysis
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What are the cytoplasm changes that occur with necrosis?
- Increased cytoplasmic eosinophilia
- Depletion of cytoplasmic Glycogen
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Types of Necrosis:
- Coagulative
- Liquificative
- Caseous
- Fat
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Types of calcification:
- Dystrophic Calcification
- Metastatic Calcification
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What are the causes of metastatic Calcification (8)?
- Parathyroid
- CRF
- XS Vitamin D (plants, rodenticides)
- Granulomatous Dz (TB, fungus)
- Neoplasia
- Lymphoma
- AS Adenocarcinoma
- Myeloma
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Signs of Hypercalcemia
- PU/PD
- Anorexia
- Constipation
- V
- CRF
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