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DNA Synthesis
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Semiconservative
one parental & one daughter goes to each daughter cells
Bidirectional
two replication fork are iniatated at the origin and as synthesizing move away from another
Template
DNA strand that is copied into complementary strand of DNA
Primer
DNA polymerase can only add nucleotide to an existing primer of DNA
Fork
the site of two strands are replicated
semidiscontinous
the top strand must be discontinously replicated in short stretches
Leading Strand
the strand that continously synthesize
Lagging Strand
the strand that discontinuously synthesize
Ozaki Fragment
short segment of RNA/DNA
Origin Binding Protein
bindsĀ & partially denatures the origin DNA while binding to another enzyme helicase
Helicase
unwind double strand DNA
Single Stranded DNA Binding Protein (SSB)
enhances the activity of helicase & prevents the unwound DNA
Primase
synthesize RNA primers required for iniating leading and lagging strand
Processivity Factors
help load the polymerase onto the primer template while anchoring the polymerase to DNA
Topoisomerase
removes the positive supercoils that form as the fork is unwound by helicase
RnaseH
removes RNA portion of Ozaki framents
Ligase
seals the nicks after filing the gaps left by DNA polymerase
Telomerase
extends 3' end
DNA Polymerase
recognized the RNA primer & extend them 5' to 3'
Replisome
to iniate, replicate DNA replication require enzyme which assemble into large complex
The Four inhibitors of Replication
Substrate Analogs, Intercalating Agents, DNA Damaging Agents, Topoisomerase Inhibitors
Author
Anonymous
ID
977
Card Set
DNA Synthesis
Description
DNA Synthesis Exam 3
Updated
2009-11-16T04:27:09Z
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