Pharm, E1/3, B Lactam

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B Lactams include:
- Penicillin
- Cephalosporins
- Cephamycins
- Carbapenems
- Monobactams
B Lactams interfere with... (Mechanism of Action)

Transpeptidase Enzyme, responsible for Peptioglycan cross-links
Suseptibility of B Lactams is dependent on:
- B Lactamase
- Permeability of Cell Well
- Sensitivity of Pen Binding Protein
Which Bacterial cell wall is NOT permeable to B-Lactam's?

G-
Bacteria can synthesize specific B-lactamases for which drugs?
- Penicillinases
- Cephalosporinases
B Lactam Drugs are effective on bacteria that are characterized by...
- Synthesis of Peptidoglycans
- Grow Rapidly
The physical and chemical properties of Pen are dependent on what molecular property?

Acyl Side Chain
Natural Pen's are effective against:
- Strep
- Staph
- G+/- Bacilli
- G+/G- Anaerobic
- Spirochetes
Natural Pen's are NOT effective against
- Pseudomonas
- Enterobacteria
- Pen-ase producing Staph
Classes of Semi-Synthetic Pens:
- Isoxazolyl Pens
- Aminopen's
- Carboxypen's
Opthalmic Isoxazolyl Pen

Cloxacillin
*Which pen's are absorbed will when given PO
- Isoxazolyl Pen (Cloxacillin, Oxacillin, Dicloxacillin, Nafcillin)
- Natural (Pen V)
PO Pens are suspended in ___, while those given IM/SQ are suspended in ___
- PO= oil
- IM/SQ= Aqueous
Which Class of Pen is active against Pen-ase producing Staph?

Semi-Synthetic
Which classes of Pen must be admin with B-lactamase inhibitors?
- Natural
- Aminopenicillins
- Carboxypen
Which semi-synthetic pens are broad spectrum?
- Amoxi
- Ampi
Which class of Pen is most effective against B fragilis?

Extended Spectrum
B-Lactamase inhibiting additive drugs
- Clavulanate
- Sulbactam
Which two Pen's have a low bioavailability in dogs, and are therefore admin with esters?
- Ampicillin
- Amoxicillin
*Which Pen CANNOT be admin IV b/c it affects cardiac conduction?

Procain Pen G
*Other form of Pen G that is absorbed for 7 days:

Benzathine Pen G
*Pens mantain a high concentration in..
- milk
- (milk:plasma= 1:5)
Pens are excreted as...(form)

80% unchanged (metabolites => allergic Rxns)
Where are most Pens exreted?
- Glomerular Filtration
- Proximal Tubule
Which Pen is excreted by bile?

Naficillin
What drug reduces the excretion of Pen via tubular secretion?

Probenecid

Author

HLW

97678

Card Set

Pharm, E1/3, B Lactam

Description

Pharm, E1/3, B Lactam

Updated

2011-08-21T01:03:28Z

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