Pharm, E1/2, Antimicrobials

Broad Spectrum ABx (6):
- Tetracyclines
- Chloramphenicol & Derivs
- Macrolides
- Lincomycins
- Fluoroquinolones
- Sulfonamides
Narrow Spectrum ABx (5):
- B Lactams
- Aminoglycosides
- Polymyxin B
- Colistin
- Rifampin
Bactericidal Drugs (6):
- B Lactams
- Polymyxin B
- Colistin
- Aminoglycosides
- Fluoroquinolones
- Metro
Bacteriostatic Drugs (5):
- Tetracyclines
- Chloramphenicol & Derivs
- Macrolides
- Lincomycins
- Sulfonamides
Bactericidal Fx are dependent on...
- Duration
- Increasing Concentration
- Post-Abx Effect
Combination Therapy is useful in which cases (5)?
- Mixed Infection
- Synergistic Fx
- Resistance
- Avoid Toxicity
- Bacterial Enzyme Inactivation
2x Bacteriostatic Drugs =>

Additive
2x Bactericidal Drugs =>

Synergistic
Bactericidal + Bacteriostatic =>

Antagonistic
Resistance due to Antimicrobial Inactivation (via enzymes) has occurred with which drugs (3)?
- Penicillins (G-, B lactamase)
- Cephalosporins (G-, B lactamase)
- Aminoglycosides
- Chloramphenicol (G+/-)
Resistance due to Alternation of Sensitive/Binding Site has occurred with which drugs (4):
- Aminoglycosides
- Erythromycin
- Fluoroquinolones
- Rifampicin
Resistance due to Decreased Permeability has occurred with which drugs (1):

Ampicillin
Resistance due to decreased Drug Accumulation has occurred with which drugs (2):
- Tetracyclines
- Fluoroquinolones
Resistance due to Alternate Metabolic Pathway has occurred with which drugs (2):
- Trimethoprim
- Sulphonamide

Author

HLW

97672

Card Set

Pharm, E1/2, Antimicrobials

Description

Pharm, E1/2, Antimicrobials

Updated

2011-08-20T18:05:12Z

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