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Functional Class
benzodiazepine (short acting)
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MOA
- 1) This short acting benzo intensifies activity of GABA
- 2) Has CNS depressant, anticonvulsant and anterograde amnestic properties
- 3) Relaxes skeletal muscles and induces sleep
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Indications
- Seizures (status epilepticus)
- Induce sedation prior to painful procedures
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Contraindications
Hypersensitivity to benzos, acute narrow-angle glaucoma, coma, shock, acute alcohol intoxication
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Precautions
Use with caution in patients with COPD, CHF and/or renal failure
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Side Effects
- 1) N/V, PVCs, hypotention
- 2) Blurred vision, retrograde amnesia
- 3) Excessive amnesia, apnea
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Interactions
- 1) Prolonged resp depression when given with other CNS depressants such as alcohol
- 2) cimeidine (Tagament) increases plasma levels of midazolam
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Dose/Route
Adult: 1.0-2.5mg slow IVP or IM q 5 mins, until seizure stops
- Pedi: 0.1 mg/kg slow IVP or IM max single dose 6 mg.
- May repeat once after 5 mins
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Pharmacokinetics
- Onset = 3-5 mins IV
- Duration = less than 2 hours
- Half-Life = 1-4 hours
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