lorazepam

benzodiazepine

• 1) Most potent of the benzodiazepines.
• 2) Acts as an anxioolytic, sedative, hypnotic and musculo-skeletal relaxant.
• 3) Intensifies GABA
• 4) Because of its short half-life, it is the preferred benzo for the treatment of pediatric seizures

• 1) Seizures (status epilepticus)
• 2) To induce sedation prior to painful procedures
• 3) Anxiety

Hypersensitivity to benzos, acute narrow-angle glaucoma, coma, shock, acute alcohol intoxication

Renal or hepatic impairment, myasthenia gravis, COPD

• 1) Anterograde amnesia, sedation
• 2) Hypertention or hypotention
• 3)Blurred vision, N/V, confusion

Effects of lorazepam will be increased when used in conjunction with other CNS depressants, alcohol or cimetidine

Adult: 1-2mg slow IVP or IM q 5min, max 8mg

Pedi: 0.1 mg/kg slow IVP or IM, max single dose 2mg (may repeate once after 5mins)

• Onset = 1-5 mins IV, 5-10 mins IM
• Half-Life = 10-20 hours