Home
Flashcards
Preview
Med Chem Exam II
Home
Get App
Take Quiz
Create
Protonsil
inactive on bacterial cultures
reduced invivo to yield sulfonilamide
example of prodrug
Sulfonamide
Sulfanilamide
pKa = 10.4
Reducing Crystalluria
1. Increase urine flow by forcing fluids
2. Raise the pH of the urine with bicarb
3. Use derivatives of sulfanilamide that have lower pKas
4. Mix sulfonamides to reach the total dose.
Trimethoprim
Inhibits Folate Reductase in the Folate biosynthesis pathway.
Toxicity and side effects
Drug Fever
Hemolytic anemia
crystalluria
Sulfacetamide
pKa 5.4
Sulfapyridine
pKa 8.4
Sulfadiazine
pKa 6.3
PABA
Sulfamerazine
pKa = 6.8
Sulfamethazine
pKa=7.2
Trisulfapyrimidines
Mixture of sulfadiazine, sulfamerazine and sulfamethazine
Sulfasalazine
prodrug for sulfapyridine
Trimethoprim
Folic Acid Biosynthesis Pathway
Acts on Folate Reductase
Dapsone
Leprosy
Author
Anonymous
ID
9649
Card Set
Med Chem Exam II
Description
Sulfonilamides
Updated
2010-03-08T22:48:14Z
Show Answers
Home
Flashcards
Preview