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Med Chem Exam II

  1. Protonsil
    • inactive on bacterial cultures
    • reduced invivo to yield sulfonilamide
    • example of prodrug
  2. Sulfonamide
  3. Sulfanilamide
    • pKa = 10.4
  4. Reducing Crystalluria
    • 1. Increase urine flow by forcing fluids
    • 2. Raise the pH of the urine with bicarb
    • 3. Use derivatives of sulfanilamide that have lower pKas
    • 4. Mix sulfonamides to reach the total dose.
    • Trimethoprim
    • Inhibits Folate Reductase in the Folate biosynthesis pathway.
  6. Toxicity and side effects
    • Drug Fever
    • Hemolytic anemia
    • crystalluria
    • Sulfacetamide
    • pKa 5.4
  8. Sulfapyridine
    • pKa 8.4
  9. Sulfadiazine
    • pKa 6.3
  10. PABA
  11. Sulfamerazine
    • pKa = 6.8
  12. Sulfamethazine
    • pKa=7.2
  13. Trisulfapyrimidines
    Mixture of sulfadiazine, sulfamerazine and sulfamethazine
    • Sulfasalazine
    • prodrug for sulfapyridine
    • Trimethoprim
    • Folic Acid Biosynthesis Pathway
    • Acts on Folate Reductase
    • Dapsone
    • Leprosy
Author
Anonymous
ID
9649
Card Set
Med Chem Exam II
Description
Sulfonilamides
Updated

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