Drugs

• Streptomycin
• In Prokaryotes

• Tetracycline
• In Prokaryotes

• Choramphenicol
• In Prokaryotes

• Erythromycin
• In Prokaryotes

• Puromycin
• In Eukaryotes and Prokaryotes

• Cyclohexamide
• In Eukaryotes

• Diptheria toxin.
• In Eukaryotes

• Ricin
• In Eukaryotes

• Causes misreading of the genetic code.
• Interferes with initiation in Prokaryotes.

• Inhibits binding of aminoacyl-tRNA to A-site.
• In Prokaryotes

Inhibits peptidyl transferase activity on ribosomes in Prokaryotes.

Binds to the 50S subunit and inhibits translocation in Prokaryotes.

• Resembles aminoacyl-tRNA and bines ot the A-ste.
• Causes premature relase of polypeptide chains in Prokaryotes and Eukaryotes.

Inhibits peptidyl tranferase activity of the 60S ribosome in Eukaryotes.

Inhibits eEF-2 and prevents translocation in Eukaryotes.

Inactivates 60S subunit of ribosome in Eukaryotes.

Affects DNA gyrase in bacterial DNA replication.

Affects reverse transcriptase. Used in AIDS patients.

Inhibits reverse transcriptase.

Affects trascription...RNA-PolII is EXTREMELY SENSITIVE to this drug.

Inhibits RNA synthesis in Prokaryotes, by binding to the Beta subunit. Does NOT affect eukaryotic RNA synthesis.

NOT specific for either prokaytoes or eukaryotes, so is not a good drug. Binds tightly to dsDNA and inhibits RNA synthesis.