-
atorvastatin- Lipitor
(MOA, Admin alert, Preg, SE, Inter.)
- MOA: HMG-CoA reductast inhibitor: blocks production ofcholesterol
- Admin: taken w/ food, may be taken anytime of day
- Pregnancy X
- SE: Muscle breakdown, GI upset, myopathies, liver damage
- Interactions: Grapefruit juice
-
choestyramine- Questran
(MOA, Admin, SE)
- MOA: binds bile acids decreasing chlesterol levels by 20%
- Admin: take before meals, other meds 1 hr befor or 4 hrs after
- SE: Severe GI upset, Vit. depletion, decrease absorb. of other meds
-
gemfibrozil- Lobid
(MOA, Admin, SE, Inter.)
- MOA: Decrease VLDL by 50%/ increase HLDs
- Admin: take w/food to decrease GI upset
- SE: Cramping,diarrhea, gallstones or liver dysfunction
- Inter: increase levels of coumadin, use w/ statins may potentiate myopathies
-
hydrochlorothiazide- HydroDiuril
(Use, MOA, SE, Inter.)
- Use: Hypertension-Diuretic
- MOA: act on renal tubules to decrease absorption of Na
- SE: K, Na depletion, Hyperglcemia
- Interaction: NSAID decrease action
-
Calcium Channel Blockers- amilodipine
(MOA, SE, Inter.)
- MOA: selectively blocks calcium channels in myocardium and
- vasculature
- SE: headaches, dizziness, flushing, reflex tachycardia
- Inter: Grapefruit juice increase absorb, alcohol potentiates vasodilation effects
-
lisinopril-Prinivil
(MOA,SE)
- MOA: RAS
- SE: bradykinin buildup becuse of blockage of AI to AII
-
doxazosin-Cardura
(Use, MOA, SE)
- Use: Alpha I adrenergic blocker for hypertentsion
- MOA: dilates arteries and veins causing a decrease in BP
- SE: first doese phenomenon, orthostatic hypotension, shrinks prostate
-
hydralazine- Apresoline
(Use, MOA, SE)
- Use: direct vasodilator
- MOA: relaxation of smooth arteriolar smooth muscles
- SE: severe reflext tachycardia, fluid retention
-
-
chronotrope
the heart rate
-
furosemide-Lasix
(Use, MOA, SE)
- Use: Loop Diuretics
- MOA: pulling fluid
- SE: fluid overload, hypokalemia
-
metoprolol-Lopressor
(Use, MOA, SE, NC)
- Use: Beta-adrenergic Blockers
- MOA: negative inotrope, negative chronotrope- slows heart
- SE:anxiety, heart failure
- NC: Low BP, HR, mood, impotence
-
digoxin-Lanoxin
(Use, MOA, SE, NC)
- Use: Cardiac Glycoside
- MOA: positive isotrope, negative chronotrope
- SE: low HR
- NC: narrow therapeutic window: hold if HR <60
-
milrinone-Primacor
(Use, MOA, SE, NC)
- Use: phosphodiesterase inhibitors
- MOA: positive inotrope
- SE: hypertension then hypotension
- NC: continuous monitoring
-
Nitroglycerine
- Inactiviated by light, heat, and air
- Glass bottle and special tubing
- Covered bottle and tubing against light
- Headache common SE
- Sublingual peak levels in 4 minutes
-
procainamide-Pronestyl
(Use, MOA, SE, NC)
- Use: sodium channel blockers
- MOA: reduces ventricular arythmias
- SE: cause Lupis
- NC: cardiac monitoring
-
amiodarone-Cardarone
(Use, MOA, SE)
- Use: Potassium Channel Blockers
- MOA: Atrial fibrilation/ ventricular arrhythmias
- SE: pulmonary fibrosis, blue hue to skin
-
Low molecular weight heparins
- More stable than IV heparin
- Can be Sub Q
- Drug of choice for DVT
-
Heparin
(MOA, Admin, measured, antidote)
- MOA: prolongs bleeding times
- Admin: IV or Sub Q
- Measured in units
- Antidote: protomine sulfate neutralizes
-
aPtt
- activated partial thromboplastin time
- how long it takes someone to stop bleeding
-
warfarin- Coumadin
(MOA, SE, NC)
- MOA: effecting vit. K dependent clotting factors (Sink)
- SE: diet high in vit K reduce effects, minor bleeding
- NC: monitor signs of bleeding, monitor PT(prothrombin time) which is reported in INR
-
clopidogrel bisulfate-Plavix
(Use, MOA, Indication, SE)
- Use: antiplatelet agents
- MOA: ADP receptor blockers alter platelet membrane
- Indication: Post thromboembolic event (MI, CVA)
- SE: few and mild, headache, dizziness, rash
- Contraindication: active bleeding-don't give w/ NSAIDs
-
reteplase
(Use, MOA, Contra)
- Use: thrombolytics
- MOA: dissolves clots
- Contra: Any recent trauma, active bleeding
- Must be given in 6 hrs of MI and 3 hrs for CVA
-
Erythropoietin
(Use, MOA, SE)
- Use: Hematopoieti Growth Factors
- MOA: promote formation of RBC
- SE: Increase risk of clotting
-
ferrous sulfate
(Use, MOA, SE, NC)
- Use: Iron deficiency anemia
- MOA: replenish iron stores
- SE: constipation
- NC: take with OJ, toxic to children
-
dopamine
(Use, MOA)
- Use: inotropic agent
- MOA: stronger contraction of heart
-
epinephrine
(Use, MOA, SE)
- Use: anaphylaxis
- MOA: vasoconstriction and opens bronchial tree
- SE: tachycardia
-
spironolactone
(MOA, Indic.)
- MOA: inhibit the action of aldosterone, K sparing diuretic
- Indic: adjunt therapy for hypertension, adjunct therapy for hirsutism
-
dextran
(MOA, Uses, concerns)
- MOA: blood volume expander
- Use: hypovolemic shock, reduction of platelet adhesiveness
- concerns: fluid overload, reactions, prolonged bleeding
-
Potassium Chloride
(Use, Alerts)
- Use: treatment of hypokalemia
- Alerts: vital signs, IV must be given slowly, carefully monitor IV site for infiltrations, oral prep can cause GI upset, monitor electrolytes as ordered
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