1. atorvastatin- Lipitor
    (MOA, Admin alert, Preg, SE, Inter.)
    • MOA: HMG-CoA reductast inhibitor: blocks production ofcholesterol
    • Admin: taken w/ food, may be taken anytime of day
    • Pregnancy X
    • SE: Muscle breakdown, GI upset, myopathies, liver damage
    • Interactions: Grapefruit juice
  2. choestyramine- Questran
    (MOA, Admin, SE)
    • MOA: binds bile acids decreasing chlesterol levels by 20%
    • Admin: take before meals, other meds 1 hr befor or 4 hrs after
    • SE: Severe GI upset, Vit. depletion, decrease absorb. of other meds
  3. gemfibrozil- Lobid
    (MOA, Admin, SE, Inter.)
    • MOA: Decrease VLDL by 50%/ increase HLDs
    • Admin: take w/food to decrease GI upset
    • SE: Cramping,diarrhea, gallstones or liver dysfunction
    • Inter: increase levels of coumadin, use w/ statins may potentiate myopathies
  4. hydrochlorothiazide- HydroDiuril
    (Use, MOA, SE, Inter.)
    • Use: Hypertension-Diuretic
    • MOA: act on renal tubules to decrease absorption of Na
    • SE: K, Na depletion, Hyperglcemia
    • Interaction: NSAID decrease action
  5. Calcium Channel Blockers- amilodipine
    (MOA, SE, Inter.)
    • MOA: selectively blocks calcium channels in myocardium and
    • vasculature
    • SE: headaches, dizziness, flushing, reflex tachycardia
    • Inter: Grapefruit juice increase absorb, alcohol potentiates vasodilation effects
  6. lisinopril-Prinivil
    • MOA: RAS
    • SE: bradykinin buildup becuse of blockage of AI to AII
  7. doxazosin-Cardura
    (Use, MOA, SE)
    • Use: Alpha I adrenergic blocker for hypertentsion
    • MOA: dilates arteries and veins causing a decrease in BP
    • SE: first doese phenomenon, orthostatic hypotension, shrinks prostate
  8. hydralazine- Apresoline
    (Use, MOA, SE)
    • Use: direct vasodilator
    • MOA: relaxation of smooth arteriolar smooth muscles
    • SE: severe reflext tachycardia, fluid retention
  9. Inotrope
  10. chronotrope
    the heart rate
  11. furosemide-Lasix
    (Use, MOA, SE)
    • Use: Loop Diuretics
    • MOA: pulling fluid
    • SE: fluid overload, hypokalemia
  12. metoprolol-Lopressor
    (Use, MOA, SE, NC)
    • Use: Beta-adrenergic Blockers
    • MOA: negative inotrope, negative chronotrope- slows heart
    • SE:anxiety, heart failure
    • NC: Low BP, HR, mood, impotence
  13. digoxin-Lanoxin
    (Use, MOA, SE, NC)
    • Use: Cardiac Glycoside
    • MOA: positive isotrope, negative chronotrope
    • SE: low HR
    • NC: narrow therapeutic window: hold if HR <60
  14. milrinone-Primacor
    (Use, MOA, SE, NC)
    • Use: phosphodiesterase inhibitors
    • MOA: positive inotrope
    • SE: hypertension then hypotension
    • NC: continuous monitoring
  15. Nitroglycerine
    • Inactiviated by light, heat, and air
    • Glass bottle and special tubing
    • Covered bottle and tubing against light
    • Headache common SE
    • Sublingual peak levels in 4 minutes
  16. procainamide-Pronestyl
    (Use, MOA, SE, NC)
    • Use: sodium channel blockers
    • MOA: reduces ventricular arythmias
    • SE: cause Lupis
    • NC: cardiac monitoring
  17. amiodarone-Cardarone
    (Use, MOA, SE)
    • Use: Potassium Channel Blockers
    • MOA: Atrial fibrilation/ ventricular arrhythmias
    • SE: pulmonary fibrosis, blue hue to skin
  18. Low molecular weight heparins
    • More stable than IV heparin
    • Can be Sub Q
    • Drug of choice for DVT
  19. Heparin
    (MOA, Admin, measured, antidote)
    • MOA: prolongs bleeding times
    • Admin: IV or Sub Q
    • Measured in units
    • Antidote: protomine sulfate neutralizes
  20. aPtt
    • activated partial thromboplastin time
    • how long it takes someone to stop bleeding
  21. warfarin- Coumadin
    (MOA, SE, NC)
    • MOA: effecting vit. K dependent clotting factors (Sink)
    • SE: diet high in vit K reduce effects, minor bleeding
    • NC: monitor signs of bleeding, monitor PT(prothrombin time) which is reported in INR
  22. clopidogrel bisulfate-Plavix
    (Use, MOA, Indication, SE)
    • Use: antiplatelet agents
    • MOA: ADP receptor blockers alter platelet membrane
    • Indication: Post thromboembolic event (MI, CVA)
    • SE: few and mild, headache, dizziness, rash
    • Contraindication: active bleeding-don't give w/ NSAIDs
  23. reteplase
    (Use, MOA, Contra)
    • Use: thrombolytics
    • MOA: dissolves clots
    • Contra: Any recent trauma, active bleeding
    • Must be given in 6 hrs of MI and 3 hrs for CVA
  24. Erythropoietin
    (Use, MOA, SE)
    • Use: Hematopoieti Growth Factors
    • MOA: promote formation of RBC
    • SE: Increase risk of clotting
  25. ferrous sulfate
    (Use, MOA, SE, NC)
    • Use: Iron deficiency anemia
    • MOA: replenish iron stores
    • SE: constipation
    • NC: take with OJ, toxic to children
  26. dopamine
    (Use, MOA)
    • Use: inotropic agent
    • MOA: stronger contraction of heart
  27. epinephrine
    (Use, MOA, SE)
    • Use: anaphylaxis
    • MOA: vasoconstriction and opens bronchial tree
    • SE: tachycardia
  28. spironolactone
    (MOA, Indic.)
    • MOA: inhibit the action of aldosterone, K sparing diuretic
    • Indic: adjunt therapy for hypertension, adjunct therapy for hirsutism
  29. dextran
    (MOA, Uses, concerns)
    • MOA: blood volume expander
    • Use: hypovolemic shock, reduction of platelet adhesiveness
    • concerns: fluid overload, reactions, prolonged bleeding
  30. Potassium Chloride
    (Use, Alerts)
    • Use: treatment of hypokalemia
    • Alerts: vital signs, IV must be given slowly, carefully monitor IV site for infiltrations, oral prep can cause GI upset, monitor electrolytes as ordered
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