-
Activation of bcl-2
Triggers release of cytochrome C from mitochondria membrane, initiating apoptosis
-
Activation of extrinsic apoptotic pathway
Fas-Fas ligand interaction or release of perforin and granzyme from NK or cytotoxic T cells
-
Nuclear signs of irreversible cell damage
Pyknosis, karyolysis, karyorrhexis
-
Chemotactic factors for neutrophils
C5a, IL8, LT B4, kallikrein
-
Cells that mediate acute inflammation
Neutrophils, eosinophils
-
Cells that mediate chronic inflammation
Monocytes
-
Sialyl Lewis acid
- Found on leukocyte membranes
- Adhesion molecule that mediates rolling by binding to E and P selectin
-
ICAM-1
Found in endothelium, mediates tight binding
-
What adhesion molecule mediates diapedesis?
PECAM-1
-
Primary amyloidosis
AL protein--Ig ight chains, seen in MM
-
Secondary amyoidosis
- AA protein, derived from serum amyloid associated protein
- Seen in chronic inflammatory diseases
-
Senile cardiac amyloidosis
Caused by transthyretin deposis
-
Diabetic amyloidosis
Associated with amylin deposits
-
Alzheimer's amyloidosis
Beta amyloid deposits
-
Dialysis-associated amyloidosis
Beta-2 microglobulin deposits, derived from MHC I proteins
-
Iron poisoning
- Cell death due to peroxidation of membrane lipids
- Presents with gastric bleeds and high anion gap metabolic acidosis
|
|