-
Abilify
- aripiprazole
- Atypical antipsychotic
- Bipolar Disorder
- agonizes D2 & 5-HT1A receptors, antagonizes 5-HT2A receptors
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: extrapyramidal disease, somnolence, anxiety, weight gain, akathisia, HA
-
Accupril
- quinapril
- Antihypertensive/HF
- ACE Inhibitor
- inhibits angiotensin converting enzyme, interfering w/ conversion of angiotensin I to angiotensin II
- BBW: fetal death
- SE: dizziness, HA, cough, hypotension, fatigue, hyperkalemia,BUN/SCr increased
-
Aciphex
- rabeprazole
- Gastric antisecretory; PPIs
- inhibits gastric parietal cell hydrogen-potassium ATPase (proton pump inhibitor)
- SE: abdominal pain, HA, diarrhea, N/V
-
Actonel
- risedronate
- Osteoporosis agent
- Biphosphonate
- inhibits osteoclast activity, reducing bone resorption and turnover (bisphosphonate)
-
Actos
- pioglitazone
- Antidiabetic
- thiazolidinediones
- increases insulin sensitivity
- SE: edema, upper respiratory infection, sinusitis, pharyngitis
- BBW: HF
-
Advair HFA
- fluticasone + salmeterol inhaled
- Antiasthmatic
- Corticosteroid/Beta-2 agonist (long-acting)
- BBW: Long-acting beta 2-adrenergic agonists (LABA), such as salmeterol, one of the active ingredients in the fluticasone propionate/salmeterol inhalation powder and aerosol , increase the risk of asthma-related death
-
Aldactone
- spirinolactone
- Antihypertensive
- K+ sparing diuretics
- antagonizes distal convoluted tubule aldosterone receptors
- BBW: tumorigen
- SE: gynecomastia, HA, diarrhea
-
Allegra-D
- fexofenadine + pseudoephedrine
- Antihistamine/decongestant
-
Altace
- ramipril
- ACE Inhibitor
- antihypertensive
- inhibits angiotensin converting enzyme, interfering w/ conversion of angiotensin I to angiotensin II
- SE: cough, hypotension, headache, dizziness
- BBW: fetal death
-
Amaryl
- glimepiride
- Antidiabetic
- Sulfonylureas
- stimulates pancreatic islet beta cell insulin release
- SE: hypoglycemia, dizziness, HA
-
Ambien
- zolpidem
- Restrictions: C-IV
- Hypnotic sedative
- Insomnia
- interacts w/ GABA; agonism at BZD-1 receptor
- SE: dizziness, somnolence, headache
-
Amoxil
- amoxicillin
- Penicillin antibiotic
- SE: diarrhea
-
Flexeril
- cyclobenzaprine
- Muscle relaxant
- centrally-acting muscle relaxant
- SE: xerostomia, drowsiness, dizziness
-
Anaprox
- naproxen
- NSAIDs
- inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
-
Antivert
- meclizine
- Anti-vertigo
- Antihistamine, 1st generation
- antagonizes central and peripheral H1 receptors (non-selective antihistamine); antagonizes cholinergic receptors, producing antiemetic effects
- SE: sedated, xerostomia, somnolence
-
Aricept
- donepezil
- Antipsychotic/Alzheimer's Disease/Dementia
- cholinesterase inhibitor
- reversibly binds to and inactivates acetylcholinesterase
- SE: insomnia, diarrhea, N/V, cramp
-
Armour Thyroid
- thyroid (porcine)
- Hypothyroidism
- thyroid hormone
- natural T3 and T4 mixture: produces various physiologic effects, including increasing metabolism
- SE: tremor, restlessness, palpitation, sweating,tachycardia, insomnia
- BBW: not for obesity treatment
-
Astelin
- azelastine nasal
- Antiallergy
- Antihistamine, 1st Gen
- antagonizes central and peripheral H1 receptors
-
Vistaril
- hydroxyzine
- Antianxiety/Antipruritic
- Antihistamines, 1st generation
- antagonizes central and peripheral H1 receptors
- SE: xerostomia, HA, somnolence
-
Ativan
- lorezapam
- Antianxiety
- BZDs 2: Mid-acting
- binds to benzodiazepine receptors; enhances GABA effects
- SE: dizziness, sedated, asthenia
-
Augmentin
- amoxicillin/clavulanate
- PCN/penicillinase inhibitor
- bactericidal; inhibits cell wall mucopeptide synthesis / inhibits beta-lactamases
- SE: diarrhea
-
Avalide
- irbesartan/hydrochlorothiazide
- ARB/Thiazide combos
- Antihypertensive
- BBW: fetal death
- SE: muscular pain, dizziness, HA, fatigue
-
Avandia
- rosiglitazone
- Antidiabetic
- Thiazolidinediones
- increases insulin sensitivity
- BBW: heart failure
- SE: edema, weight gain
-
Avapro
- irbesartan
- ARBs
- Antihypertensive
- selectively antagonizes angiotensin II AT1 receptors
- BBW: fetal death
- SE: HA, fatigue
-
Avelox
- moxifloxacin
- Fluoroquinolones antibiotic
- bactericidal; inhibits DNA gyrase and topoisomerase IV
- BBW: tendonitis
- SE: diarrhea, dry eyes
-
Avodart
- dutasteride
- BPH
- prostate anti-inflammatory
- inhibits types I and II 5-alpha-reductase, interfering w/ conversion of testosterone to 5-alpha-dihydrotestosterone
- SE: reduced libidio, ejaculation disorder, impotence, disorder of breast
-
Bactrim
- sulfamethoxazole/trimethoprim
- Sulfonamide antibiotics
- for sulfamethoxazole: bacteriostatic; competitively inhibits bacterial or fungal dihydropteroate synthetase, preventing PABA conversion to folic acid and inhibiting growth
- SE: Stevens-Johnson syndrome, C. diff diarrhea
-
Bactroban
- mupirocin topical
- Antibacterial - (Nasal - MRSA) (Topical - impetigo, S. aureus/S. pyogenes lesions)
- selectively binds to bacterial isoleucyl transfer-RNA synthetase, inhibiting protein synthesis
- SE: pruritis, burning sensation
-
Benicar-HCT
- olmesartan + HCT
- ARB/Thiazide combos
- Antihypertensive
- BBW: fetal death
- SE: dizziness, hyperuricemia
-
Benicar
- olmesartan
- ARBs
- antihypertensive
- selectively antagonizes angiotensin II AT1 receptors
- SE: headache, dizziness, hypotension
- BBW: fetal death
-
Bentyl
- dicyclomide
- GI antispasmotic
- irritable bowel
- antagonizes acetylcholine at muscarinic receptors (anticholinergic); relaxes smooth muscle, inhibits bradykinin- and histamine-induced spasms
- SE: constipation, blurred vision
-
Biaxin
- clarithromycin
- H. pylori
- Macrolides anitbiotic
- binds to P site of 50S ribosomal subunit, interfering w/ protein synthesis
- SE: diarrhea, taste disorder, HA
-
Boniva
- ibandronate
- Osteoporosis agent
- bisphosphonates
- inhibits osteoclast activity, reducing bone resorption and turnover
- SE: upper resp infection, hypertension, indigestion, N/V
-
BuSpar
- buspirone
- Antianxiety agent
- non-BZD
- binds to serotonin and dopamine D2 receptors
- SE: dizziness, nervousness, headache, nausea
-
Cardizem
- diltiazem
- Antiarrhythmias
- Non-dihydropyridine CCB
- inhibits calcium ion influx into vascular smooth muscle and myocardium, relaxing smooth muscle, decreasing peripheral vascular resistance, dilating coronary arteries and prolonging AV node refractory period
- SE: peripheral edema, dizziness, HA, fatigue, bradycardia, cough
-
Cardura
- doxazosin
- BPH agent/Antihypertensive
- alpha-1 antagonist
- antagonizes peripheral alpha-1 adrenergic receptors
- SE: dizziness, fatigue, hypotension, headache
-
Catapres
- clonidine
- Antihypertensive
- Central alpha-2 agonist
- stimulates alpha-2 adrenergic receptors
- SE: AV block
-
Ceftin
- cefuroxime
- 2nd gen, Cephalosporin
- bactericidal; inhibits cell wall mucopeptide synthesis
- SE: diarrhea, N/V, vaginitis
-
Celebrex
- celecoxib
- NSAIDs
- COX-2 inhibitor
- selectively inhibits cyclooxygenase-2 and reduces prostaglandin synthesis
- BBW: increase CV thrombotic, MI, stroke, GI bleed
- SE: hypertension, GI bleed, HA
-
Celexa
- citalopram
- Antidepressants
- SSRIs
- selectively inhibits serotonin reuptake
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: somnolence, tremor, N/V, fatigue, agitation
-
Chantix
- varenicline
- Smoking Cessation Aid
- Nicotine
- agonizes and blocks alpha-4-beta-2 nicotinic acetylcholine receptors
- BBW: Serious neuropsychiatric events (eg, depression, suicidal ideation, suicide attempt and completed suicide) have been reported in patients taking varenicline
- SE: dream disorder, HA, N/V
-
Cialis
- tadalafil
- Erectile dysfunction
- inhibits phosphodiesterase type 5, enhancing effects of nitric oxide-activated increases in cGMP
- SE: HA, flushing, nasopharyngitis, myalgia
-
Cipro
- ciprofloxacin
- Fluorosuinolon antibiotic
- bactericidal; inhibits DNA gyrase and topoisomerase IV
- BBW: tendonitis
- SE: diarrhea, N/V, burning sensation in eye, eye pain
-
Cleocin
- clindamycin
- Other antibiotics
- binds to 50S ribosomal subunit, interfering w/ protein synthesis
- BBW: Pseudomembranous colitis
- SE: diarrhea, abdominal pain
-
Cogentin
- benztropine
- Anti-Parkinson
- antagonizes acetylcholine and histamine receptors
- SE: tachycardia, blurred vision, constipation, nausea
-
Colcrys
- colchicine
- Gout
- in FMF, interferes w/ inflammasone complex assembly in neutrophils and monocytes, preventing IL-1 activation; in gout, concentrates in PMN cells and inhibits microtubule polymerization, preventing neutrophil migration and activity related to gout sx
- SE: diarrhea, N/V, myelosuppresion
-
Combivent
- ipratropium + albuterol MDI
- Anti-asthmatic
- Beta-2 Agonists/Short-acting inhaled
- SE: upper resp depression, bronchitis, dyspnea
-
Pacerone
- amiodarone
- Anti-arrhythmic
- class-III
- prolongs action potential phase 3 (class III antiarrhythmic)
- SE: photodermatitis, hypotension, bradyarrhythmic
- BBW: pulmonary toxicity, hepatotoxicity, proarrhythmic effects
-
Coreg
- carvedilol
- Antihypertensive
- non-selective Beta-blocker
- selectively antagonizes alpha-1 adrenergic receptors; antagonizes beta-1 and beta-2 adrenergic receptors (selective alpha and non-selective beta blocker)SE: hypotension, bradyarrhythmia, dizziness, fatigue, hyperglycemia
-
Coumadin
- warfarin
- Anticoagulant
- inhibits vitamin K-dependent coagulation factor synthesis (II, VII, IX, X, proteins C and S)
- BBW: fatal bleeding
- SE: bleeding, tissue necrosis, gangrene
-
Cozaar
- losartan
- Antihypertensive
- ARBs
- selectively antagonizes angiotensin II AT1 receptors
- SE: dizziness, fatigue, hypotension
- BBW: fetal death
-
Crestor
- rosuvastatin
- Antihyperlipidemia
- Statin
- inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase
- SE: myalgia, HA, asthenia
-
Cymbalta
- duloxetine
- Antidepressant
- SNRI
- inhibits norepinephrine and serotonin reuptake
- BBW: Increased risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: dizziness, HA, N/Vfatigue, xerostomia
-
Deltasone
- prednisolone
- Anti-inflammatory
- corticosteroids
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: osteoporosis, hypertension
-
Depakote
- divalproex
- Antiepileptic/Antipsychotic
- increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation
- SE: abdominal pain, diarrhea, nausea, vomiting, dizziness, somnolence, asthenia
- BBW: hepatotoxicity
-
Desyrel
- trazadone
- Antidepressant
- increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: xerostomia, HA, dizziness, fatigue, somnolence
-
Detrol
- tolterodine
- Urinary bladder modifier
- Anticholinergic
- antagonizes acetylcholine receptors
- SE: xerostomia, HA, constipation
-
Diflucan
- fluconazole
- Antifungal
- Candidiasis
- inhibits cytochrome p450 and sterol C-14 alpha-demethylation
- SE: HA, N/V
-
Dilantin
- phenytoin
- Antiseizure
- modulates neuronal voltage-dependent sodium and calcium channels
-
Diovan-HCT
- valsartan + HCT
- Antihypertensive
- ARB/Thiazide combos
- BBW: fetal death
- SE: nasopharingitis, increased BUN
-
Diovan
- valsartan
- Antihypertensive
- ARBs
- selectively antagonizes angiotensin II AT1 receptors
- BBW: fetal death
- SE: hypotension, HA, increased BUN, dizziness
-
Ditropan
- oxybutynin
- Antispasmodics
- Anticholinergic
- antagonizes acetylcholine at muscarinic receptors; relaxes bladder smooth muscle, inhibits involuntary detrusor muscle contractions
- SE: pruritis, xerostomia, rash, constipatio, diarrhea
-
Drisdol
- ergocalciferol
- Vitamin D
- stimulates intestinal calcium and phosphorus absorption; stimulates bone mineralization
- SE: hypercalcemia, renal impairment, calcification of soft-tissue, growth retardation
-
DuoNeb
- ipratropium + albuterol
- Antiasthmatic
- Beta-2 Agonists: Short-acting Inhaled; Anticholinergics, Inhaled
- SE: bronchitis, upper resp infect, HA
-
Duragesic
- fentanyl
- Opioid analgesic
- binds to various opioid receptors, producing analgesia and sedation
- BBW: fatal resp depression
-
Dyazide
- triamtrene/HCTZ
- Antihypertensive
- K+ sparing + thiazide diuretic
- BBW: hyperkalemia
- SE: asthenia, dizziness, HA
-
Bayer
- aspirin
- Antiplatelet
- platelet inhibitor
- SE: bleeding, gastric ulcer
-
Effexor
- venlafaxine
- Antidepressant
- SNRIs
- inhibits norepinephrine, serotonin, and dopamine reuptake
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: sweating, weight loss, constipation, loss of appetite, N/V, xerostomia, asthenia, dizziness, HA, somnolence
-
Elavil
- amitriptyline
- Antidepressant
- TCA
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: weight gain, xerostomia, somnolence, HA, dizziness, blurred vision
-
Estrace
- estradiol
- Estrogen hormone
- binds to estrogen receptors, developing and maintaining female sex characteristics and reproductive systems
- BBW: Estrogens increase the risk of endometrial cancer
-
Evista
- raloxifene
- Osteoporosis agent
- estrogen receptor modulator: selectively binds to estrogen receptors, inhibiting bone resorption and turnover
- BBW: DVT, PE
- SE: hot sweats, leg cramp
-
Flagyl
- metronidazole
- H. pylori
- Antibacterial/Antiprotozoal
- disrupts DNA and inhibits nucleic acid synthesis
- BBW: carcinogenic
- SE: HA, N/V, dizziness, vaginal discharge
-
Flomax
- tamsulosin
- BPH
- alpha-1 selective blocker
- selectively antagonizes prostate alpha-1a adrenergic receptors, relaxing smooth muscle and improving urine flow
- SE: backache, rhinitis, abnormal ejaction, dizziness, HA,
-
Flonase
- fluticasone
- Antiallergy
- nasal spray, corticosteroids
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: bronchitis, Upper resp infect, throat irritation
-
Flovent
- fluticasone
- Antiasthmatic
- Corticosteroids
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: HA, upper resp infect, sinusitis
-
Folic Acid
- vitamin B9
- Vitamins
- participates in DNA synthesis and erythropoiesis
- SE: confusion, loss of appetite
-
Fosamax
- alendronate
- Osteoporosis agent
- Bisphosphonates
- inhibits osteoclast activity, reducing bone resorption and turnover
- SE: fever, flu-like symptom
-
Glucophage
- metformin
- Antidiabetic
- biguanides
- decreases hepatic glucose production and intestinal glucose absorption; increases insulin sensitivity
- SE: diarrhea, flatulence, vomiting, nausea
- BBW: lactic acidosis
-
Glucotrol
- glipizide
- Antidiabetic
- Sulfonylureas
- stimulates pancreatic islet beta cell insulin release
- SE: hypoglycemia, weight gain
-
Glucovance
- glyburide/metformin
- Antidiabetic
- sulfonylureas/biguanides
- BBW: lactic acidosis
- SE: lactic acidosis, jaundice, diarrhea, upper resp infection, GI
-
Humalog
- insulin lispro
- Antidiabetic
- insulin
- stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism
-
Humulin N
- insulin NPH
- Antidiabetic
- insulin
- stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism
-
Microzide
- hydrochlorothiazide
- Antihypertension
- Thiazide diuretic
- inhibits sodium reabsorption in the distal tubules causing increased excretion of sodium & water as well as potassium & hydrogren ions
- SE: orthostatic hypertension, hypotension, hypokalemia, anorexia
-
Hytrin
- terazosin
- Antihypertensive/BPH
- alpha-1 antagonist
- antagonizes peripheral alpha-1 adrenergic receptors
-
Hyzaar
- losartan/HCTZ
- Antihypertensive
- ARB/Thiazide combos
-
Imdur
- isosorbide mononitrate
- Antianginal
- vasodilators/nitrates
- stimulates cGMP production, resulting in vascular smooth muscle relaxation
-
Inderal
- propranolol
- Antihypertensive
- Non-selective Beta-Blocker
- non-selectively antagonizes beta-1 & beta-2 adrenergic receptors
- BBW: Reports of exacerbation of angina and myocardial infarction have been noted following abrupt discontinuance of propranolol
- SE: dizziness, fatigue, CHF, heart block, asthma, bronchospasm
-
Calan
- verapamil
- Antihypertensive/Antiaginal
- non-dihydropyridines CCBs
- inhibits calcium ion influx into vascular smooth muscle and myocardium
- SE: edema, hypotension, dizziness, HA, sinusitis, flu-like sumptoms
-
Januvia
- sitagliptin
- Antidiabetic
- DPP-4 Inhibitor
- inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release, decreasing glucagon levels
- SE: pancreatitis, upper respiratory infection, nasopharyngitis
-
Keflex
- cephalexin
- Antibiotic
- cephalosporins, 1st Gen
- bactericidal; inhibits cell wall mucopeptide synthesis
-
Kenalog
- triamcinolone topical
- Topical corticosteroids
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: HA, pharyngitis, flu-like symptoms, Cushing's syndrome
-
Keppra
- levetiracetam
- Antiseizure
- Anticonvulsant
- SE: somnolence, depression, pharyngitis
-
Klonopin
- clonazepam
- Antiepileptic
- BZDs - Long-acting
- binds to benzodiazepine receptors; enhances GABA effects
-
Lamictal
- lamotrigine
- Antiepileptic
- bipolar/seizure disorder
- SE: nausea, vomiting, blurred vision
- BBW: life-threatening rash
-
Lanoxin
- digoxin
- inotropes/pressors
- inhibits sodium-potassium ATPase
-
Lantus
- insulin glargine
- Antidiabetes
- insulin
- stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism
-
Lasix
- furosemide
- Antihypertensive
- Loop diuretic
- inhibits loop of Henle and proximal and distal convoluted tubule sodium and chloride resorption
- BBW: Furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion.
- SE: hyperuricemia, hypomagnesemia
-
Levaquin
- levofloxacin
- Antibiotics
- fluoroquinolones
- bactericidal; inhibits DNA gyrase and topoisomerase IV
- SE: QT prolongation, altered mental status,
- BBW: Tendonitis/Tendon Rupture
-
Levitra
- vardenafil
- Erectile dysfunction
- inhibits phosphodiesterase type 5, enhancing effects of nitric oxide-activated increases in cGMP
-
Lexapro
- escitalopram
- Antidepressant
- SSRIs
- selectively inhibits serotonin reuptake
-
Lidoderm
- lidocaine topical
- Analgesics, local - minor cuts & burns
- inhibits Na ion channels, stabilizing neuronal cell membranes and inhibiting nerve impulse initiation and conduction
-
Lioresal
- baclofen
- Muscle relaxants
- inhibits monosynaptic and polysynaptic spinal reflexes (centrally-acting muscle relaxant)
-
Lipitor
- atorvastatin
- Antihyperlipidemia
- HMG-CoA inhibitor
- inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase
- SE: rhabdomyalgia, diarrhea, UTI, nasopharyngitis
-
Lodine
- etodolac
- NSAIDs
- exerts anti-inflammatory, analgesic, and antipyretic effects by inhibiting prostaglandin synthesis
- BBW: cardiovascular thrombotic, MI, & stroke, ulceration & stomach/intestine perforation
- SE: edema, GI bleed
-
Loestrin 24 Fe
- norethindrone/ethinyl estradiol/ferrous fumarate
- Oral contraceptive
- suppresses LH & FSH, inhibiting ovulation; alters cervical mucus & endothelium
- BBW: cigarrette smoking increases the risk of serious cardiovascular SE from oral contraceptive use
- SE: edema, breakthrough-bleeding, breast tenderness, infertility
-
Lopid
- gemfibrozil
- Antihyperlipidemia
- Fibrates
- inhibits peripheral lipolysis; decreases hepatic free fatty acid extraction; inhibits synthesis and increases clearance of VLDL carrier apolipoprotein B; mechanism of increased HDL unknown
- SE: abdominal pain, indigestion
-
Lopressor
- metoprolol tartrate
- Antihypertensive
- Selective beta-1 blocker
- selectively antagonizes beta-1 adrenergic receptors
- BBW: Avoid Abrupt Cessation d/t sever angina exacerbation, MI, & ventricular arrhythmias - taper over 1-2wk
- SE: hypotension, fatigue, dizziness, HF, bradyarrhythmia
-
Lortab, Vicodin
- hydrocodone/acetaminophen
- Pain managment
- Opioid analgesic
- acetaminophen MOA unknown, produces analgesia and anti-pyretic effects; hydrocodone binds to various opioid receptors, producing analgesia and sedation
- SE: drowsiness, sedated, respiratory depression
-
Lotensin
- benazapril
- Antihypertensive
- ACE inhibitor
- inhibits angiotensin converting enzyme, interfering w/ conversion of angiotensin I to angiotensin II
- BBW: can cause injury or death to fetus
- SE: dizziness, HA, cough
-
Lotrel
- amlodipine/benazepril
- Antihypertensive
- CCB/ACE-inhibitor
- BBW: can cause fetal death
- SE: edema, cough
-
Lotrisone
- clotrimazole/betamethasone
- Topical antifungal
- antifungal/corticosteroids
- SE: paresthesia, dry skin, sensation of burning
-
Lovaza
- omega-3 FAs
- Antihyperlipidemia
- reduces hepatic triglyceride synthesis
- SE: burping, indigestion, taste altered
-
Lumigan
- bimatoprost ophthalmic
- Agent for glaucoma
- increases aqueous humor outflow
- SE: dry eye, eye irritation, iris color change
-
Lunesta
- eszopiclone
- Insomnia
- interacts w/ GABA-benzodiazepine receptor complexes
- SE: dizziness, HA, disorder of taste, respiratory tract infection
-
Lyrica
- pregabalin
- Anti-seizure/Anti-neuralgic
- binds alpha2-delta subunit of calcium channels reducing neurotransmitter release; produces antinociceptive and antiseizure effects
- SE: dizziness, blurred vision, somnolence, tremor
-
Macrobid
- nitrofurantoin
- Antibacterial
- bactericidal or bacteriostatic; interferes w/ metabolism and inhibits protein and cell wall synthesis
- SE: loss of appetite, N/V
-
Medrol
- methylprednisolone
- Corticosteroids, systemic
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: hypertension, hyperglycemia, osteoporosis
-
Dolophine, Methadose
- methadone
- Opioid analgesic, Opioid Addiction Tx
- binds to various opioid receptors, producing analgesia and sedation (opioid agonist)
- BBW: incomplete cross-tolerance, resp depression, QT prolongation
- SE: constipation, n/v, dizziness, sedated, hypotension, respiratory depression
-
Mevacor
- lovastatin
- Antihyperlipidemia
- HMG-CoA
- inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase
- SE: abdominla pain, constipation, rhabdomyolysis
-
Micardis
- telmisartan
- Antihypertensive
- ARBs
- selectively antagonizes angiotensin II AT1 receptors
- BBW: fetal death
- SE: upper respiratory infection
-
DiaBeta
- glyburide
- Antidiabetic
- Sulfonylureas
- stimulates pancreatic islet beta cell insulin release
- SE: hypoglycemia, cholestatic jaundice syndrome
-
Minocin
- minocycline
- Antibiotics
- Tetracyclines
- bacteriostatic; inhibits protein synthesis
- SE: dizziness, tooth discolored
-
Miralax, Glycolax
- polyethylene glycol 2250
- Constipation
- Osmotic laxative
- causes water retention in stool, producing laxative effect
- SE: diarrhea, flatulence, stomach cramps
-
Mobic
- meloxicam
- NSAIDs
- inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
- BBW: risk of CV thrombotic event, MI, stroke - also stomach/intestine perforation
- SE: edman, upper respiratory infection, indigestion, n/v, bleeding
-
Motrin
- ibuprofen
- NSAIDs
- inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
- BBW: risk of CV thrombotic event, MI, stroke - also stomach/intestine perforation
- SE: edman, upper respiratory infection, indigestion, n/v, bleeding
-
MS Contin
- morphine sulfate
- Opioid analgesic
- binds to various opioid receptors, producing analgesia and sedation
- BBW: abuse potential, fatal respiratory depression if use 100-200mg ER in opioid-naive ptn
- SE: N/V, constipation, dizziness, HA
-
Robitussin AC
- codeine/guaifenesin
- Antitussive/Expectorant
-
Namenda
- memantine
- Alzheimer Dz/Dementia
- NMDA receptor antagonist
- binds N-methyl-D-aspartate receptors, may slow Ca++ influx and nerve damage
- SE: confusion, dizziness, HA
-
Nasacort AQ
- triamcinolone nasal
- Antiallergy
- Corticosteroid, nasal spray
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: pharyngitis, HA, influenza-like illness
-
Nasonex
- mometasone nasal
- Antiallergy
- Corticosteroid, nasal spray
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: HA, candidiasis
-
Neurontin
- gabapentin
- Antiseizure
- SE: somnolence, dizziness, ataxia, nystagmus
-
Nexium
- esomeprazole
- Gastric antisecretory
- PPIs; H. pylori
- inhibits gastric parietal cell hydrogen-potassium ATPase
- SE: diarrhea, abdominal pain
-
Niaspan
- niacin
- Antihyperlipidemia
- participates in tissue respiration oxidation-reduction reactions; decreases hepatic LDL and VLDL production; inhibits adipose tissue lipolysis; decreases hepatic triglyceride esterification; increases lipoprotein lipase activity
- SE: flushing, N/V
-
Nitrostat
- nitroglycerin
- Antianginal
- Vasodilators
- stimulates cGMP production, resulting in vascular smooth muscle relaxation
- SE: headache, lighheadedness
-
Nizoral
- ketoconazole topical
- Antifungal
- Seborrhea/Dandruff
- inhibits fungal cell membrane ergosterol synthesis
- SE: burning sensation, pruritus
-
Trandate
- labetalol
- Antihypertensive
- Selective alpha & non-selective beta blocker
- selectively antagonizes alpha-1 adrenergic receptors; antagonizes beta-1 and beta-2 adrenergic receptors
- SE: orthostatic hypotension (IV), dizziness, fatigue, HA, N/V
-
Norvasc
- amlopidine
- Antihypertensive/Angina/Prinzmetal's
- DHP CCB
- inhibits calcium ion influx into vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina
- SE: peripheral edema, HA, flushing
-
Novolog
- insulin aspart
- Anti-diabetic (Type 1 & 2) - rapid-acting
- stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism
- SE: hypoglycemia, weight gain, lipodystrophies
-
NuvaRing
- etonogestrel/ethinyl estradiol vaginal
- Contraceptives
- suppresses LH and FSH, inhibiting ovulation; alters cervical mucus and endometrium
- BBW: Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use.
- SE: weight gain, sinusitis, upper resp infection
-
Nystop
- nystatin
- Antifungal antibiotic
- Candidiasis
- binds to cell membrane sterols, increasing permeability
- SE: skin irritation, SJS
-
Omnicef
- cefdinir
- Antibiotic
- 3rd Gen Cephalosporin
- bactericidal; inhibits cell wall mucopeptide synthesis
- SE: diarrhea
-
Orapred
- prednisolone
- Anti-inflammatory
- Corticosteroids, systemic
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: hypertension, hyperglycemia, depression, mood swings
-
Ortho-Cyclen
- norgestimate/ethinyl estradiol
- Oral contraceptives
- Monophasic OCPs
- suppresses LH and FSH, inhibiting ovulation; alters cervical mucus and endometrium
- BBW: Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use.
- SE: edema, weight gain
-
Ogestrel
- norgestrel/ethinyl estradiol
- Oral contraceptives
- Monophasic OCPs
- suppresses LH and FSH, inhibiting ovulation; alters cervical mucus and endometrium
- BBW: Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use.
- SE: edema, weight gain
-
OxyContin
- oxycodone CR
- Opioid analgesic
- binds to various opioid receptors, producing analgesia and sedation (opioid agonist)
- BBW: abuse potential, fatal resp depression
- SE: somnolence, N/V, constipation
-
Pamelor
- nortriptyline
- Antidepressant
- TCA
- inhibits norepinephrine and serotonin reuptake
- BBW: increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: constipation
-
Patanol
- olopatadine ophthalmic
- Anti-allergy
- selectively antagonizes histamine H1 receptors; inhibits histamine release from mast cells
- SE: altered tastse, HA, common cold
-
Paxil
- paroxetine
- Antidepressant
- SSRI
- selectively inhibits serotonin reuptake
- BBW: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: constipation, diaphoresis, HA, somnolence, tremor, asthenia
-
Pepcid
- famotidine
- Anti-ulcer agent
- H2 blocker
- selectively antagonizes histamine H2 receptors
- SE: constipation, diarrhea, HA, dizziness
-
Percocet
- oxycodone/acetaminophen
- Opioid analgesic
- SE: dizziness, sedated, somnolence
-
Phenergan
- promethazine
- Anti-emetic
- 1st Gen Antihistamine
- non-selectively antagonizes central and peripheral H1 receptors; possesses anticholinergic properties, resulting in antiemetic and sedative effects
- BBW: IV injection can cause extravasation, the use in peds <2 y/o can cause resp depression
- SE: depression, dizziness, sedated, somnolence
-
Plaquenil
- hydroxychloroquine
- Anti-malarial
- DMARDs
- SE: disorder of cornea
-
Plavix
- clopidogrel
- Antiplatelets/Stroke
- Platelet inhibitor
- irreversibly binds to adenosine diphosphate receptors, inhibiting platelet activation and aggregation
- BBW: In patients who are CYP2C19 poor metabolizers, clopidogrel at recommended doses forms less of that metabolite and has a smaller effect on platelet function.
- SE: bleeding
-
Plendil
- felodipine
- Antihypertensive
- DHP CCB
- inhibits calcium ion influx into vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospastic angina
- SE: HA, peripheral edema, flushing, tachycardia
-
Pravachol
- pravastatin
- Antihyperlipidemia
- HMG-CoA reductase inhibitor
- SE: musculoskeletal pain, upper resp infection, diarrhea, N/V
-
Premarin
- conjugated estrogens
- Estrogen Hormone
- binds to estrogen receptors, developing and maintaining female sex characteristics and reproductive systems
- BBW: endometrial cancer
-
Prevacid
- lansoprazole
- Gastric antisecretory
- PPIs/H. pylori
- inhibits gastric parietal cell hydrogen-potassium ATPase (proton pump inhibitor)
- SE: diarrhea, constipation, abdominal pain
-
Prilosec
- omeprazole
- Anti-ulcer agent
- PPIs/H. pylori
- inhibits gastric parietal cell hydrogen-potassium ATPase
- SE: abdominal pain, diarrhea, HA
-
Procardia
- nifedipine
- Antihypertensive/Antiaginal
- DHP CCB
- inhibits calcium ion influx into vascular smooth muscle and myocardium
- SE: hypotension, peripheral edema, flushing, HA, dizziness
-
Proscar
- finasteride
- BPH
- Prostate anti-inflammatory
- inhibits type II 5-alpha-reductase, interfering w/ conversion of testosterone to 5-alpha-dihydrotestosterone
- SE: abnormal ejaculation, breast tenderness, reduced libidio
-
Protonix
- pantoprazole
- Anti-ulcer agent
- PPIs/H. pylori
- inhibits gastric parietal cell hydrogen-potassium ATPase
- SE: abdominal pain, diarrheam, HA
-
Proventil HFA
- albuterol inhaled
- Anti-asthmatic
- Beta-2 agonist; short-acting inhaled
- stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle (selective beta agonist)
- SE: pharyngitis, throat irritation, rhinitis, upper resp infection, nausea
-
Ventolin HFA
- albuterol inhaled
- Anti-asthmatic
- Beta-2 agonist; short-acting inhaled
- stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle (selective beta agonist)
- SE: pharyngitis, throat irritation, rhinitis, upper resp infection, nausea
-
Prozac
- fluoxetine
- Antidepressant
- SSRI
- selectively inhibits serotonin reuptake
- BBW: increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: insomnia, somnolence, rhinitis, loss of appetite
-
Pyridium
- phenazopyridine
- Urinary tract analgesic
- the precise mode of action is unknown but when excreted in the urine, it promotes topical analgesia on the mucosa of the urinary tract, thus relieving pain, burning, urgency and frequency
- SE: HA
-
Reglan
- metoclopramide
- Anti-emetic
- sensitizes tissues to acetylcholine, stimulating upper GI tract motility; antagonizes central and peripheral dopamine receptors, producing antiemetic effects
- BBW: tardive dyskinesia
- SE: asthenia, HA, somnolence, fatigue
-
Relafen
- nabumetone
- NSAIDs
- inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
- BBW: risk of CV thrombotic event, MI, stroke - also stomach/intestine perforation
- SE: edman, upper respiratory infection, indigestion, n/v, bleeding
-
Remeron
- mirtazapine
- Antidepressant
- Tetracyclic
- antagonizes alpha-2 adrenergic and serotonin 5-HT2 receptors
- BBW: increased the risk of suicidal thinking and behavior in children, adolescents, and young adults
- SE: weight gain, somnolence, xerostomia, dizziness
-
Requip
- ropinirole
- Anti-Parkinson/Dystonia
- Dopamine agonist
- stimulates dopamine receptors
- SE: dizziness, N/V, HA
-
Restoril
- temazepam
- Sedative/Insomnia
- BZDs; Mid-acting
- binds to benzodiazepine receptors; enhances GABA effects
- SE: somnolence, blurred vision
-
Risperdal
- risperidone
- Bipolar Disorder
- Antipsychotics, 2nd generation
- antagonizes dopamine D2 receptors, serotonin 5-HT2 receptors
- BBW: Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo.
-
Robaxin
- methocarbamol
- Muscle relaxant
- SE: dizziness, HA, nystagmus, somnolence, vetigo
-
Seroquel
- quetiapine
- Bipolar
- Atypical Antipsychotic, 2nd Gen
- antagonizes dopamine D2 receptors, serotonin 5-HT2 receptors
- BBW: Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo.
-
Singulair
- montelukast
- Antiasthmatic
- Leukotriene inhibitor
- selectively binds to cysteinyl leukotriene receptors
- SE: headache
-
Skelaxin
- metaxalone
- Muscle relaxant
- centrally-acting muscle relaxant
- SE: dizziness, HA, somnolence, N/V
-
Soma
- carisoprodol
- Muscle relaxant
- centrally-acting muscle relaxant
- SE: somnolence, dizziness, HA
-
Spiriva
- tiotropium inhaled
- Antiasthmatic
- Anticholinergic
- antagonizes acetylcholine receptors, producing bronchodilation
- SE: xerostomia, pharyngitis, sinusitis, upper resp infection
-
Suboxone
- buprenorphine/naloxone
- Opioid Dependence
- SE: sweating, constipation, N/V, HA, vasodilation, pain
-
Synthroid
- levothyroxine
- Hypothyroidism
- Synthetic T4
- produces various physiologic effects, including increasing metabolism
- BBW: not for weight loss treatment
- SE: MI, liver failure, seizure
-
Tamiflu
- oseltamivir
- Antiviral
- Tx of acute illness d/t influenza A or B
- inhibits influenza neuraminidase
- SE: abdominal pain, N/V
-
Temovate
- clobetasol topical
- Anti-inflammatory, topical
- Corticosteroids - highest potency
- inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
- SE: nasopharyngitis, upper resp infection
-
Tenoretic
- atenolol/chlorthalidone
- Antihypertensive
- Selective B-blocker + thiazide diuretic
- SE: hypotension, dizziness, fatigue, HA, dyspnea
-
Tenormin
- atenolol
- Anti-HTN/Anti-angina/post-MI
- Selective Beta-blocker
- selectively antagonizes beta-1 adrenergic receptors
- BBW: BB therapy should not be withdrawn abruptly (particularly in patients with CAD), but gradually tapered to avoid acute tachycardia, HTN, & ischemia
- SE: bradycardia, cold extremities, hypotension, dizziness, depression, fatigue
-
Tessalon
- benzonatate
- Anticough
- Antitussive
- anesthetizes respiratory passage, lung, and pleural stretch receptors, reducing cough reflex
- SE: oral hypoesthesia if capsule broken, dizziness, HA, sedated, somnolence
-
Topamax
- topiramate
- Antiseizure/migraine/HA
- SE: dizzines, impaired psychomotor performance, paresthesia, somnolence, fatigue
-
Toprol-XL
- metoprolol succinate
- Antihypertensive
- Selective B-1 blocker
- selectively antagonizes beta-1 adrenergic receptors
- BBW: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred
- SE: dizziness, fatigue, pruritus
-
Tricor
- fenofibrate
- Antihyperlipidemia
- Activate PPARa
- inhibits triglyceride synthesis and stimulates catabolism of triglyceride-rich lipoproteins (fibric acid derivative)
- SE: backache, abdominal pain, AST/liver function test abnormal
-
Tussionex
- chlorpheniramine/hydrocodone
- Antitussive
- Antihistamine/Antitussive combos
- chlorpheniramine antagonizes central and peripheral H1 receptors, drying nasal and sinus passages (non-selective antihistamine); hydrocodone binds to various opioid receptors, producing analgesia, sedation and antitussive effects (opioid agonist)
- SE:
-
Ultracet
- tramadol/acetaminophen
- Analgesic
- BBW: APAP can cause liver toxicity if > 4g/d
- SE: somnolence, constipation, xerostomia, dizziness
-
Ultram
- tramadol
- Opioids analgesic
- binds to mu opioid receptors and weakly inhibits norepinephrine/serotonin reuptake, producing analgesia
- SE: dizziness, drowsiness, somnolence, HA, constipation, nausea
-
Valium
- diazepam
- Antianxiety/Antiseizure/Alcohol dependence
- BZDs - long acting
- binds to benzodiazepine receptors; enhances GABA effects
-
Valtrex
- valacyclovir
- Antiviral
- Herpes/Varicella/Zoster
- inhibits DNA polymerase; incorporates into viral DNA
- SE: HA, rash, N/V
-
Vasotec
- enalapril
- Antihypertensive
- ACE-Inhibitor
- inhibits angiotensin converting enzyme, interfering w/ conversion of angiotensin I to angiotensin II
- BBW: fetal death
- SE: cough, hypotension, dizziness, elevated BUN/SCr, hyperkalemia
-
Pen VK
- penicillin V potassium
- Antibiotic, PCN
- Tx of respiratory tract, otitis media, sinusitis, skin, UTI
- inhibits bacterial cell wall synthesis by binding to one or more of the penicillin binding proteins (PBPs)
- SE: diarrhea, N/V, oral candidiasis
-
Viagra
- sildenafil
- Erectile dysfunction
- Phosphodiesterase-5 Enzyme
- inhibits phosphodiesterase type 5, enhancing effects of nitric oxide-activated increases in cGMP
- SE: HA, dyspepsia, flushing
-
Vibramycin
- doxycycline
- Tetracycline abx
- inhibits protein synthesis by binding with the 30S & 50S ribosomal subunits
- SE: anorexia, yellow teeth, bone suppression, photosensitivity
-
Vigamox
- moxifloxacin ophthalmic
- Fluoroquinolone abx
- Tx of bacterial conjunctivitis
-
Voltaren
- diclofenac ophthalmic
- NSAIDs
- Post-operative inflammation following cataract extraction; temporary relief of pain
-
Vytorin
- ezetimibe/simvastatin
- Antihyperlipidemia
- inhibitor of intestinal absorption/HMG-CoA reductase inhibitor
-
Wellbutrin
- buPROPion
- Antidepressant/Smoking Cessation Aid
- Tx of MDD; smoking cessation
- inhibits NE & dopamine uptake
- BBW: depression & suicidal thoughts in smoking cessation; antidepressants increase risk of suicidal thinking in children & adolescent
- SE: xerostomia, HA, dizziness, insomnia, weight loss, tachycardia
-
Xanax
- alprazolam
- Antianxiety
- BZDs; short-acting
- Restriction: C-IV
- binds to benzodiazepine receptors; enhances GABA effects
- SE: drowsiness, fatigue, memory impairment, sedation, somnolence, cognitive disorder
-
Xopenex
- levalbuterol
- Antiasthmatic
- Beta-2 agonist; short-acting
- relaxes bronchial smooth muscle by action of beta-2-receptors with little effect on the heart
- SE: increases serum glucose, hypokalemia, tremor, rhinitis
-
Ocella / Yasmin / Yaz
- ethinyl estradiol/drospirenone
- Oral contraceptive
- Estrogen & Progestin combination
- Prevention of pregnancy; tx of PMDD; tx of acne
- suppresses LH & FSH, inhibiting ovulation; alters cervical mucus & endometrium
- BBW: smoking increases risk of serious CV events
-
Zanaflex
- tiZANidine
- Centrally-acting muscle relaxant
- Alpha-2-Adrenergic agonist
- an alpha2-adrenergic agonist agent which decreases excitatory input to alpha motor neuron
- SE: hypotension, somnolence, dizziness, xerostomia, weakness
-
Zantac
- ranitidine
- Anti-ulcer agent/GERD
- Histamine-H2 antagonist
- inhibition of histamin at H2-receptors of the gastric parietal cells, which inhibits gastric acid secretion, gastric volume, & hydrogen ion concentration are reduced
- SE: constipation, diarrhea, abdominal pain, HA
-
Zebeta
- bisoprolol
- Antihypertensive
- Beta-Blocker, Selective Beta-1
- selectively antagonizes beta-1 adrenergic receptors
- SE: fatigue, HA
-
Zestril / Prinivil
- lisinopril
- Antihypertensive
- ACE Inhibitor
- inhibits angiotensin converting enzyme, interfering w/ conversion of angiotensin I to angiotensin II
- BBW: fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy
- SE: hypotension, HA, dizziness, cough, hyperkalemia, BUN/SCr increase
-
Zestoretic / Prinzide
- lisinopril + HCTZ
- Antihypertensive
- ACE Inhibitor/Diuretic
- BBW: fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy
- SE: hypotension, HA, dizziness, cough, hyperkalemia, BUN/SCr increase
-
Zetia
- ezetimibe
- Antihyperlipidemic
- inhibits intestinal absorption of cholesterol; leads to a decreased delivery of cholesterol to the liver; decrease TC, TG, LDL but increase HDL
- SE: upper resp infection, arthralgia
-
Ziac
- bisoprolol + HCT
- Antihypertensive
- Selective Beta-1/Thiazide diuretic
-
Zithromax / Z-pack
- azithromycin
- Macrolide antibiotic
- Otitis media, bacterial sinusitis, CA-pneumonia, SST, PID
- bacteriostatic; binds to P site of 50S ribosomal subunit, interfering w/ protein synthesis
- SE: diarrhea, N/V
-
Zocor
- simvastatin
- Antihyperlipidemic
- HMG-CoA reductase inhibitor - the rate limiting step in cholesterol biosynthesis
- BBW: rhabdomyolysis - starting dose is 40mg; patient must be on the drug at least 1 year in order to be on 80mg
- SE: creatine kinase level increase, resp infection, abd pain, constipation
-
Zoloft
- sertraline
- Antidepressant
- SSRI
- selectively inhibits serotonin reuptake
- BBW: Suicidality -incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders
- SE: sexual dysfunction, drowsiness, weight gain, HA, somnolence
-
Zovirax
- acyclovir
- Antiviral
- Tx of genital herpes simplex virus (HSV)
- inhibits DNA polymerase; incorporates into viral DNA
- SE: malaise
-
Zyloprim
- allopurinol
- Agent for gout/nephropathy/hyperuricemia
- Xanthine Oxidase Inhibitor
- inhibits xanthine oxidase, interfering w/ conversion of hypoxanthine and xanthine to uric acid
-
Zyprexa
- olanzapine
- Antipsychotic
- Tx of schizophrenia/mania/bipolar
- antagonizes dopamine, serotonin 5-HT2
- BBW: not approved for dementia-related psychosis; incr. mortality risk in elderly dementia pts on conventional or atypical antipsychotics;
- SE: weight gain, somnolence, extrapyramidal, dyspepsia, dizziness
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