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Immunohistochemistry

  1. ER/PR +
    • Breast
    • Ovary
    • Endometrium
    • Papillary thyroid
    • Skin adnexal tumors
    • Sarcomas
    • Meningioma (PR only)
    • Solid-pseudopapillary neoplasm of pancreas (PR only)
  2. Metaplastic/Sarcomatoid Carcinoma
    • CK5/6 about 50%
    • P63 60%
    • AE1/3 40%
    • SMA 70%
  3. Lung vs Meso
    • CK5/6 Meso+
    • D2-40 Meso+
    • Calretinin Meso+ (nuclear)
    • TTF-1 Lung+
    • CD15 Lung+
    • MOC31 Lung+
    • CEA Lung+
    • BerEp4 Lung+
    • WT1 (only if male)
  4. D2-40
    • Kaposi sarcoma 100%
    • Angiosarcoma 72%
    • Seminoma 100% (nonseminomatous germ cell negative)
    • Mesothelioma 90% (lung adeno 0-7%, various carcinomas 20-40%)
    • Dermatofibroma 100%
  5. Keratin+ EMA-
    • Hepatocellular CA
    • Germ cell tumors
    • Granulosa cell tumor (keratin 30-50%)
  6. Keratin- EMA+
    • Meningioma
    • Pulmonary sclerosing hemangioma (keratin+/-)
Author
elzotter
ID
95925
Card Set
Immunohistochemistry
Description
Immunohistochemistry
Updated

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