1. Cerebral palsy is a ________ disorder?
  2. Inability to perform rapid alternating movement is?
    Dysdiadokokinesia - HD
  3. The lower part of the ascending reticular activating system controls?
  4. Lower motor neuron involvement results in?
    Hypotonia, hyporeflexia, fasciculations
  5. What disease has dance like movements?
    Huntington's disease
  6. What disease has blurry vision?
    Multiple sclerosis
  7. What disease has cogwheel rigidity?
    Parkinson's disease
  8. What disease has fibrillary tangles?
    Alzheimer's disease
  9. What disease has loss of balance reactions?
    Parkinson's disease
  10. What disease has involvement of the diaphragm?
  11. What disease has muscle atrophy?
  12. What disease has torticollis?
  13. What disease has slow movement?
    Parkinson's disease
  14. What disease has trouble initiating movement?
    Parkinson's disease
  15. What disease has senile plaque?
    Alzheimer's disease
  16. What disease has spongiform encephalopathy?
  17. What disease has progressive bulbar palsy and pseudobulbar palsy?
  18. What disease has festinating gait?
    Parkinson's disease
  19. What disease has prion as the culprit?
  20. What disease has the agonist and antagonist muscle contracting simultaneously?
  21. What disease uses levadopa?
    Parkinson's disease
  22. - CNS disorder
    - variety of presentations
    - involuntary
  23. - muscle atrophy
    - progressive
    - normal cognition
  24. - test performed along the lateral side of sole of foot
    - upper motor neuron sign
    - indicative of pyramidal tract damage
    Positive Babinski
  25. - diplopia
    - bladder incontinence
    - heat intolerant
  26. Preservation of:
    - bowel and bladder
    - cerebellum
    - frontal cortex
  27. - hippocampus
    - temporal lobe
    - frontal lobe
    Alzheimer's disease
  28. - learning is lost
    - eating disturbance
    - sleep disturbance
    Alzheimer's disease
  29. - masked face
    - postural reflex embarrassment
    - decrease in fine motor skills
    Parkinson's disease
  30. - prednisone
    - interferon beta
    - baclofen
  31. - plaque
    - inflammation
    - Lhermitte's sign
  32. - dementia
    - fatal
    - inherited
    Huntington's chorea
  33. - sustained muscle contractions
    - uncontrolled
    - botox injection may help
  34. Changes in the lateral aspect of the spinal cord, brain stem, cerebral cortex.
  35. - motor neuron degeneration & scarring
    - peripheral nerve damage
    - muscle fiber atrophy
  36. Plaques & tangles
    Alzheimer's disease
  37. Cognitive deficits with denial of memory problems, subtle personality as mobility & ADL intact.
    Alzheimer's disease
  38. - Cortical atrophy involving predominantly the frontal and temporal regions with sparing of the posterior 2/3.
    - Much less common and sometimes clinically indistinguishable from Alzheimer's.
    Pick's disease
  39. Loss of inhibition of socially unacceptable and previously supressed behavior which emerges early in the disease often overshadowing the memory disturbance.
    Pick's disease
  40. Neurons balloon in the area of involved tissue, but there are not the plaques or tangles seen in AD.
    Pick's disease
  41. - Initial parkisonism unresponsive to standard medications, progressing to deterioration of cognition.
    - Dementia is usually a late manifestation of the disease.
    Lewy body dementia
  42. - New lesions appear at previously attacked sites
    - Lesions can be acute or chronic.
  43. - Relapsing/Remitting
    - Secondary progressive
    - Primary progressive
    - Progressive relapsing
    Stages of MS
  44. The most common manifestation of Parkinson's disease.
  45. - present at rest
    - has a regular rhythm
    - doesn't interfere with ADLs
    - decreases or disappears with movement
    Resting tremor
  46. Lewy bodies within the substantia nigra.
    Parkinson's disease
  47. - Atrophy of the caudate nucleus and putamen.
    - Leads to enlarged ventricles.
    Huntington's disease
  48. - Acetylcholine is reduced.
    - Dopamine is increased.
    - Loss of controlled movement.
    Huntington's disease
  49. - Autosomal dominant
    - Each child has a 50% chance
    - Tip of chromosome 4
    Huntington's disease
  50. - sporadic
    - familial (rare)

    - new variant (related to mad cow diesase)
    Types of CJD
  51. Much less common and sometimes indistinguishable from AD.
    Pick's disease
  52. This disorder exhibits highly variable clinical and neuropathologic overlap with AD and PD.
    Lewy Body Dementia
  53. - too much dopamine and norepinephrine
    - too little acetylcholine and GABA
    Huntington's disease
  54. There is an excess of dopamine and excessive excitation of the thalamocortical pathway, which explains the excessive movement.
    Huntington's disease
  55. Image Upload 1
    HD - enlargement of lateral ventricles
  56. Image Upload 2
  57. - Sporadic neurodegenerative disorder
    - Loss of midbrain dopamine neurons
    - Presence of Lewy body inclusions
    Parkinson's disease
  58. Which 2 diseases are commonly involved with dementia?
    HD & AD
  59. Which 2 diseases has unwanted movements?
    Dystonia & HD
  60. Which 2 diseases have increased incidence in particular climates?
    ALS & MS
  61. Which 2 diseases can be drug induced?
    Dystonia & PD
  62. Which 2 diseases have abnormal protein?
    CJD & AD
  63. Which 2 diseases are involved with depression?
    HD & PD
Card Set
degenerative dz