-
Control symptoms of psychosis,
calm without sedation,
first-generation drugs are Haldol and Thorazine,
second-generation drugs Risperdal and Abilify
Antipsychotics
-
Psychotic disorders in relation to antipsychotic drugs
Schizophrenia & Manic-Depressive Psychosis
-
Positive symptoms of schizophrenia:
- Hallucinations
- Delusions
- Disorganized thought process
- Paranoia
-
Negative symptoms of schizophrenia:
- Withdrawal
- Lack of initiative
- Failure to maintain hygiene
-
Another name of second generation antipsychotic drugs
- Atypical antipsychotics or
- atypical neuroleptics
-
Another use of antipsychotic drugs rather than schizophrenia and manic-depressive pshycosis:
Prevent relapse in individuals with chronic disorders
-
Low Potency Class
(Thorazine & Mellaril)
Large amount will have significant effect
LARGE = BIG
-
High Potency Class:
Small amount will have significant effect
small amount = BIG EFFECT
-
Non- Antipsychotic Drugs used to Treat Psychosis
- Benzodiazepines
- Antidepressants
- Mood Stabilizers
- Other agents for SE
-
Time range injections work
15 to 30 minutes
-
Time PO (oral) medications work
One to four hours
-
Which route is faster for medications?
Liquid
-
What can decrease oral absorption?
- Food
- Coffee
- Smoking
- Other Drugs
-
Two major characteristics of drug actions:
1. They all bind to brain dopamine receptors
2. They produce a degree of indifference to both external and internal stressful stimuli
-
Location of drug metabolization:
Liver
-
Side effects of first-generation antipsychotic medications:
- Constipation
- Dry Mouth
- Blurred Vision
- Postural Hypotension
- Urinary Retention
- Weight Gain (2nd Generation too)
- Sedation
-
Most common movement disorder
Subjective sense of restlessness
Move continuously
Akathisia
-
"Feeling antsy"
Inability to sit still
Pacing floor
Not being frightened
Akathisia
-
Sustained, involuntary muscle spasms
(mostly common in head & neck)
Dystonia
-
Expressing thoughts of worry or concerns
Having fears, even if unable to state the source of the worry
Often having somatic symptoms
Anxiety
-
Exhibiting escalating anxiety and anger
Vocalizing concerns/complaints
Possibly demonstrating destructive behaivor
Agitation
-
Disorder characterized by sudden fever, rigidity, tachycardia, hypertension, decreased LOC
Neuroleptic Malignant Syndrome
-
Treatment of Neuroleptic Malignant Syndrome
- D/C of antipsychotics
- Administration of medications
-
First antidepressants
Tricyclic
-
-
Peak time of antidepressants
Four to six hours
-
Tricyclic and related antidepressants treat:
- Panic Disorder
- OCD
- Psychotic Depression w/illusions
-
These are side effects of what drug:
Blurred vision
Dry mouth
Rapid HR
Constipation
Urinary retention
Impaired memory
Anticholinergics
-
Medication to manage acute mania
Mood Stabilizers
-
Lithium, Tegretol, Valproic Acid, and Divalproex
- Antimanic Drugs
- (Mood Stabilizers)
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