It is used to reverse the sedative effect of benzodiazepines
Mechanism of Action
Flumazenil antagonizes the actions of benzodiazepines in the CNS. Inhibits their action on the gamma aminobutyric acid- benzodiazepine complex. Reverse the sedative effects of the benzodiazepine.
Onset of Action
Onset:1-5 min
Peak:6-10 min
Duration:2-4 hours
Half Life:54 min
Indications
To reverse CNS and respiratory depression associated with benzodiazepines
Contraindications
Know hypersensitivity to drug
Precautions
Administer with caution to PT’s dependant on benzodiazepines because it mayinduce life-threatening benzodiazepine withdrawal, do not use asa “coma cocktail”
Side Effects
dizziness
fatigue
headache
nervousness
agitation
flushing
confusion
convulsions
dysrhythmias
nausea
vomiting.
Adult Dose
0.2 mg IV over 30 seconds, repeated as needed to a max dose of 1.0mg