-
Picornaviruses (5)
- Naked ss + linear
- Polio
- Echovirus--aseptic meningitis
- Rhinovirus--common cold
- Coxsackievirus--aseptic meningitis, hand foot and mouth disease, myocarditis
- HAV
-
Reovirus (2)
- Naked ds linear
- Reovirus--Colorado tick fever
- Rotavirus
-
-
Norwalk virus
- SS + linear naked (calicivirus)
- gastroenteritis
-
Flavivirus (5)
- ss + linear enveloped
- HCV
- Yellow fever
- Dengue fever
- St. Louis encephalitis
- West Nile
-
Togavirus (3)
- SS+ enveloped
- Rubella
- Eastern equine encephalitis
- Western equine encephalitis
-
Retrovirus (2)
- ss + linear enveloped
- HIV
- HTLV--T cell leukemia
-
Coronavirus
- ss + linear enveloped
- common cold
-
Orthomyxovirus
- SS - linear segmented enveloped
- Influenza
-
Paramyxovirus (4)
- SS - linear NONsegmented enveloped
- Parainfluenza--croup
- RSV
- Rubeola
- Mumps
-
Rhabdovirus
- SS - linear enveloped
- Rabies
-
HDV
ss - circular enveloped
-
Negative RNA viruses
- Arenaviruses
- Bunyaviruses
- Paramyxoviruses
- Orthomyxoviruses
- Filoviruses
- Rhabdoviruses
- ("always bring polymerase or fail replication")
-
Protein production in picornaviruses
One long polypeptide precursor is cleaved by capsid protease into functional proteins
-
Segmented dsRNA naked virus that causes gastroenteritis in the winter
Rotavirus--destruction of vili impairs Na and water reabsorption
-
Hemagluttinin and neuraminidase
- Hemagluttinin mediates viral entry into host cell
- Neuraminidase mediates release of virion progeny
-
Palivizumab
Antibody against fusion protein F, inhibits ability of RSV to fusion with epithelial cells
-
Red spots with blue-white centers on buccal mucosa (Koplik spots)
Measles--may progress to subacute sclerosing panencephalitis
-
Marker of previous HBV vaccination
HBsAB
-
Hep B antigen indicating active viral replication
HBeAg
-
CD4 count needed for AIDS diagnosis
Under 200
-
Nef gene (HIV)
Downregulates MHC I, increases viral virulence
-
At what CD4 count is PCP a risk in HIV patients?
Under 200
-
At what CD4 count are candida esophagitis, toxo, and histo a risk in HIV patients?
Under 100
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