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4 symptoms of asthma
- 1. Dyspnea
- 2. Chest tightness
- 3. Coughing (may be only symptom, esp in kids)
- 4. Wheezing
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Additional s/s of asthma
- 1. Irritability, quietness or fatigue
- 2. Runny / stuffy nose ***
- 3. Chest pain / heart palpatations
- 4. Dark circles under eyes / watery eyes
- 5. Scratchy throat
- 6. Flare up of eczema ***
- 7. Heartburn
- 8. Children c/o upset stomach
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Steps in diagnosing asthma
- 1. Complete medical hx
- 2. Physical exam
- 3. PFT
- 4. Additional test to exclude other possibilities
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Interview - LOC
- Alert / responsive
- Lethargic
- Stuporous
- Semicomatose (only respond to pain)
- Coma (no response to pain)
- Obtunded - drowsy state, dec cough or gag
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6 ADL criteria
- 1. Bathing with sponge, bath or shower
- 2. Dressing
- 3. Toilet use
- 4. Transferring to bed or chair
- 5. Urine / bowel continence
- 6. Eating
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Subjective symptoms
- Orthopnea
- General malaise
- Dyspnea
- Pain
- Nose / throat symptoms
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Orthopnea
- Dyspnea except in upright position
- (heart problems, CHF)
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General malaise
Electrolyte imbalance
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Dyspnea grades
- Grade 1 - normal dyspnea after unusual exertion
- Grade 2 - dyspnea after hills or stairs
- Grade 3 - dyspnea after normal speed walk
- Grade 4 - dyspnea after short slow walk
- Grade 5 - dyspnea at rest
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8 Pain questions
- 1. Location
- 2. Quality
- 3. Severity (on 10 pt scale)
- 4. Aggrivating factors
- 5. Relieving factors
- 6. Hx
- 7. Context
- 8. Accompanying symptoms
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Nose and throat symptoms
- 1. Excessive nasal secretions from irritants, pollution, allergens
- 2. Itching or burning of nose / throat
- 3. Dysphagia / hoarseness
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Adult normal vital signs
- HR: 60-100
- RR: 12-20
- BP: 120/80
- Temp: 37C or 98.6F
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Children normal vital signs
- HR: 80-120
- RR: 20-30
- BP: 100/65
- Temp: 37C or 98.6F
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Physical exam for 7 items
- 1. Hyperexpanded chest
- 2. Hunched shoulders
- 3. Accessory muscle use
- 4. Chest deformity
- 5. Prolonged exhalation
- 6. Nasal mucosal swelling, secretions, nasal polyps, sinusitis, rhinitis
- 7. Skin conditions (atopic dermatitis or eczema)
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Types of tactile fremitus
Vocal fremitus - voice vibrations
Pleural rub fremitus - grating sensation du to roughened pleural surfaces
Rhonchial fremitus (palpable rhonchi) - secretions in the airways
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5 Percussion sounds
- Resonance - normal air filled lungs (hollow)
- Flatness - sternum, muscles, atelectasis
- Dullness - fluid filled organs, pleural effusion, pneumonia (drum sound)
- Tympany - air filled stomach, hyperinflation
- Hyperresonance - asthhma, emphysema, pneumothorax (booming sound)
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Normal diaphragmatic excursion
3 to 5 cm
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Vesicular normal breath sounds
- Silent
- Bronchial breath sound - normal over trachea or bronchi
- If over lung periphery, lung consolidation
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Unilateral wheeze
- Not asthma
- Foreign body obstruction
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Abnormal breath sounds
- Wheeze
- Silent chest
- Rales and ronchi - secretions
- Stridor - Inspiration, swelling or foreign body obstruction
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Xray with asthma
- Increased bronchial wall markings (inflammation)
- Flattened diaphragm
- Patchy infiltrates from atelectasis
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ABG with mild to moderate asthmatic episode
Uncompensated respiratory alkalosis with hypoxemia
Needs oxygen therapy
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ABG with severe asthmatic episode
Uncompensated respiratory acidosis with hypoxemia
Needs mechanical ventilation and oxygen therapy
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RBC normal values
- Male: 4.7 to 6.1 million cells / mcl
- Femal: 4.2 to 5.4
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Hemoglobin normal values
- Male: 13.8 to 17.2 gm/dl
- Female: 12.1 to 15.1
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Hematocrit normal values
- Male: 40.7 to 50.3%
- Female: 36.1 to 44.3%
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WBC normal values
- 4500 to 10000 cells/mcl
- elevated indicates bacterial infection
- reduced indicates viral infection
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Eosinophil normal values
- < 350 cells/mcl
- elevated indicates allergic diseases or asthma
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Immunoglobulins
antibodies produced by the immune system in response to bacteria, viruses or foreign bodies
if IgE levels are high, allergy testing!
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Screen for immunodeficiency
To determine if diseases are present to make it difficult for the body to fight infections
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Sweat chloride testing for children with chronic asthma
- r/o cystic fibrosis
- diagnosis of asthma in children < 3 is difficult
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Age to test PFT for diagnosis of asthma
5
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Define diurnal variability
variability (improvement or deterioration) experienced in PFTs within one day
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How often should PFTs be performed
- When asthma is under control
- Then every 1 to 2 years
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Is asthma obtructive or restrictive?
- Both
- Primarily obstructive that can cross over to restrictive
- Goal: manage before it becomes restrictive
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Normal FVC and FEV1
- FVC: 4.8 L
- FEV1: 70% of FVC (minimum)
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Normal PF
- 10 L/sec or 600 L/min
- Best way to monitor pt with asthma and measure MDI
- 60 L/m or >=20% in PF is dianostic of asthma
- Should measure daily
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Classification of interpretation of % predicted
- 80-100% Normal
- 60-79% Mild
- 40-59% Moderate
- <40% Severe
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PFT reversibility values
- FEV1: 12% and 200ml
- or 12% in FVC
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Medication hold times for pre-post testing
- SABA: 4-6 hours
- LABA: 12 hours
- Methylxanthines: 12 hours
- Slow release methylxanthines: 24 hours
- Ipratropium bromide: 6-8 hours
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Percent change formula
(Post FEV1 - Pre FEV1) / (Pre FEV1) X 100
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Bronchoprovocation tests
- Methacholine
- Histamine
- Cold air
- Exercise
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Medication hold times for bronchoprovocation test
- Bronchodilators: 8 hours
- Methylxanthines: 12 hours
- Cromolyn Sodium: 24 hours
- Antihistamines: 48 hours
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DLCO in asthma
- helps differentiate between asthma and emphysema
- Normal is 25 ml CO/min/mmHg (STPD)
- Normal in asthma
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Allergic reaction process
- Antigen or allergen inhaled or ingested
- Immune system detects and releases IgE antibodies
- IgE attach to mast cells and basophils to act as guards
- When allergen/antigen contacts mast cell, IgE shoots hole into the mast cell
- Mast cell releases histamine, leukotrienes and chemicals resulting in allergic reaction
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Medication hold times for allergy test
Antihistamines: 2 days
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Allergy test types
Skin-prick: red bumps within 20 minutes
- Intracutaneous test: only if skin prick inconclusive
- monitor patient for systemic reaction
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Blood allergy test
- Use if not advisable to dc antihistamines
- Radioallergensorbent testing (RAST)
- Enzyme-lined immunosorbent assay test (ELISA)
- Less accurate, more expensive, slower
- Thus, less used
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Immunotherapy (allergy shots or desensitization)
- Decreases IgE
- Increasing doses of allergen extract 1-2 per week
- Maintenance dose in 3 to 6 months (symptom relief)
- Then, once a week, reducing to every 4 weeks
- Wait 20 minutes
- Program lasts 3 to 5 years
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Non-Invasive Markers (Biomarkers)
- Sputum and blood for eosinophilic cationic protein ECP
- FeNO
- Metabolites in exhaled breath condensate EBC
- Needs further studies before approved to monitor
- not usually asked
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Infant and children other possible diagnosis
- 1. Allergic rhinits (hay fever) or sinusitis ***
- 2. Swallowing problems
- 3. Congenital heart disease
- 4. Obstruction of the large or small airways
- 5. Tumors or enlarged lymph nodes
- 6. Cystic fibrosis ***
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Adult other possible diagnosis
- 1. COPD ***
- 2. Pulmonary embolism
- 3. Heart disease
- 4. VCD ***
- 5. Airway tumors
- 6. Coughing due to drug reaction
- 7. Pregnancy
- 8. GERD ***
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