Membrane lipids S2M2

  1. What are the four major phospholipids
    • Phosphotidylcholine
    • Phosphatidylserine
    • Phosphatidylethanolamine
    • Phosphatidylinositol
  2. All phospholipids contain
    Fatty acids
  3. Cardiolipin is important for what membrane
  4. What is the only glycerophospholipid that is antigenic
  5. Dipalmitoylphosphatidylcholine is a major component of
    Lung surfactant
  6. What is found in snake and bee venom that makes them especially toxic
  7. Phospholipase A2 is important for the synthesis of
    Arachidonic acid
  8. Phospholipase A2 is found to be in high amounts of what secretions
  9. What inhibits Phospholipase
  10. Platelet activating factor (PAF) is released from phagocytic cells and has what effect
    • Causes platelets to aggregate
    • Causes anaphylactic responses
    • Causes macrophages to produce super oxide radicals
  11. Phosphatidylethanolamine is found to be abundant in what tissue
    Nerve tissue
  12. Phosphatidylcholine is found to be abundant in what tissue
    Heart muscle
  13. Plasmalogen deficiency plays an important role in
    Alzheimers disease
  14. What phospholipid is abundant in myelin sheaths
  15. What determines blood groups
    • Gangliosides
    • "The Gangli guys are always the ones making decisions"
  16. What is the enzyme deficient in Tay-Sachs disease
    Hexoamanidase A
  17. What is a classic clinical finding in Tay-Sachs disease
    Cherry red macula
  18. What accumulates in Tay-Sachs
  19. What are the symptoms for Gaucher disease
    • Hepatosplenomegaly
    • Mental retardation
    • Osteoporosis
    • "Auch!!, mental retardation, osteoporosis, and a big spleen!"
  20. What is deficient and accumulating in Gaucher disease
    • Gluco-ceribrosidase (deficient)
    • Glucocerebroside (accumulating)
  21. What are symptoms of Fabry disease
    • Kidney/Heart failure
    • Reddish purple skin rashes
    • "It ain't no fable, her skin is as red as a stable"
  22. What is deficient and accumulating in Fabry disease
    • Galactosidase (deficient)
    • Globosides (accumulating)
    • affecting patients "sides" with skin rashes
  23. Neimann Pick disease has what symptoms
    • Mental retardation
    • Hepatosplenomegaly
    • "Don't pick retardation or hepatosplenomegaly"
  24. What is deficient and accumulating in Neimann Picks disease
    • Sphingomyelinase (deficient)
    • Sphingomyelin (accumulating)
    • "Neimann marcus makes you sphing"
  25. What are the symptoms of Krabbes disease
    • Blindness
    • Deafness
    • Mental deterioration
    • "Krabbs are blind, deaf and deteriorated"
  26. What is deficient and accumulating in Krabbes disease
    • B-Galactosidase (deficient)
    • Galactocerebroside (accumulating)
    • "Krabbs want to go to the galactic empire"
  27. Sandhoff disease has what symptoms
    • Mental retardation
    • Blindness
    • Muscle weakness
    • Seizures
    • Same as Tay Sachs but with visceral involvement
  28. What is deficient and accumulating in Sandhoffs disease
    • Hexoaminidase (deficient)
    • Globosides (accumulate)
  29. What is the rate limiting step for cholesterol synthesis
    • HMG-CoA reductase
    • "OMG, did you just stop cholesterol synthesis!?"
  30. What is the rate limiting step of Bile acid synthesis
    7 alpha-hydroxylase
  31. 7 alpha-hydroxylase requires what for activation
    Thyroid hormones and Vit C
  32. What are the secondary bile acids
    • Deoxycholic acid
    • Lithocholic acid
  33. What is the only possible mechanism for excretion of excess cholesterol in the feces
    Bile acids
  34. What are some symptoms of an obstructed bile duct
    • Pale stool
    • Itching
    • Jaundice
Card Set
Membrane lipids S2M2