Ativan (Lorazepam)

  1. Class
    Benzodiazepine, Tranquilizer, Anticonvulsant, sedative, and hypnotic
  2. Description
    Lorazepam is the most potent benzodiazepine available. It has strong anti-anxiety, sedative, hypnotic and skeletal muscle relaxant properties, and a relatively short half-life
  3. Mechanism of Action
    Benzodiazepines bind to specific sites on gamma-aminobutyric acid (GABA) Type A receptors within the brain. GABA is the major inhibitory neurotransmitter of the central nervous system. Increased GABA levels cause sedation.
  4. Onset of Action
    • Onset: IV: 1-5 min IM: 15-30 min

    • Peak: IV: 15-20 IM: 2 hours

    • Duration: IV: 6-8 hours IM: 6-8 hours

    • Half -Lfe: IV: 10-20 hours IM: 10-20 hours

  5. Indications
    Major motor seizures, status epilepticus, premedication before cardioversion, muscle spasms, and acute anxiety.
  6. Contraindications
    Hypersensitivity to drug
  7. Precautions
    Should be diluted with NS or D5W prior to IV administration. Seizures may reoccur due to short half-life. Additional dose may be required.
  8. Side Effects
    Amnesia,blurred vision, drowsiness, hallucinations, tachycardia, headache, hypotension nausea, respiratory depression, vomiting
  9. Adult Dose
    • IV 0.5-2.0 mg

    • IM 1.0-4mg

  10. Pedi-Dose
    0.05-0.10mg/kg max 4mg
  11. Max Dose
    Administer as needed
  12. Routes of Administration
    IV, IM, IO
  13. How Supplied
Card Set
Ativan (Lorazepam)
Ativan (Lorazepam)