-
Raynaud phen vs disease
- Raynaud phenomena = associated with CTD
- -constriction of small digital arteries
- Raynaud disese = not assoc with disease
- -need >2yrs of s/s b/f dx
- -disoder of cold sensitivity
- -due to incr endothelin-1, estrogen
-
Erythromelalgia
-defn
-associated with
-tx
- Paroxysmal vasodilation of feet = s/s of burn, pain, red, warmth
- -trigger = incr temp
- -assoc with Raynaud's phen, PCV, TTP< MS, SLE, DM, HTN
- -acquired type due to: 1) mushroom posioning, 2) topical alcohol exposure
- -tx: immerge into cold water, misoprostol, TCA, Gabapentin
-
Sneddon syndrome
- -livedo reticularis + cerebral vascular infarcts
- -poor px
- -AD inheritence
- -antiphospholipid Ab and may have SLE
-
Chronic headaches + livedo reticularis
Marker for increased risk of stroke
-
a) Livedo reticularis vs
b) Livedo racemosis vs
c) Cutis Marmorata
- a) netlike mottled red/blue discoloration of skin, esp legs, triggered by cold
- -assoc: SLE, DM, Scleroderma, Rhe fever, RA, hep C, parvovirus B19, syphillis,
- -s/e of amantadine
b) if L.Ret present with warming
c) PSL mottling of skin, marble like, esp in F in cold
-
P-ANCA
Ab agt myeloperoxidase
- less specific (vs c-ANCA) for:
- MSPA
- Churg Strauss
- Drug induced vsculitis
-
C-ANCA
Ab agt protease 3 (PR3)
- Specific for:
- Wegner's granulomatosis
- Microscoic polyarterisit
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