Describe the allosteric regulation of the pyruvate dehydrogenase complex.
There are two energy state that allosteric regulation occurs in, high and low.
In high energy NADH, ATP and acetyl-CoA inhibit the pyruvate dehydrogenase complex, preventing Acetyle-CoA, NADH and ATP formation in the cycle.
In low energy, pyruvate and ADP stimulate the pyruvate dehydrogenase complex.