BioChem

Pyruvate's C₄ skeleton loses a C, becoming a C₃ (hydroxyethyl) which eventually become Acetyl-CoA. The lose of the C is a irreversable step, except in plants and bacteria via the clyoxylate cycle.



There are two energy state that allosteric regulation occurs in, high and low.

In high energy NADH, ATP and acetyl-CoA inhibit the pyruvate dehydrogenase complex, preventing Acetyle-CoA, NADH and ATP formation in the cycle.

In low energy, pyruvate and ADP stimulate the pyruvate dehydrogenase complex.