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Acetylcholine (Miochol-E)
- Class: Direct-Acting Cholinergic Agonist
- MOA: Directly stimulates muscarinic and nicotinic receptors
- Therapeutically of little importance except topically in treatment of glaucoma
- Side Effects: Diarrhea, Diaphoresis(sweating), Miosis, Bronchospasm, Urinary urgency, Salivation
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Bethanechol(Urecholine)
Class Direct_Acting Cholinergic Agonist
MOA: Directly stimulates muscurainic receptrs on the gastrointestinal and urinary smooth muscle but has a stronger structure that makes it last longer in the body.
Therapeutic: Reflux esophagitis & urinary retention (post operative, post partum)
Side Effects: Diarrhea, Diaphoresis(sweating), Miosis, Bronchospasm, Urinary urgency, Salivation
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Pilocarpine (Isopto Carpine)
- Class: Direct-Acting Cholinergic Agonist
- MOA:directly stimulates muscarinic receptors
Therapeutic use are primarily in ophthalmologySide Effects: Diarrhea, Diaphoresis(sweating), Miosis, Bronchospasm, Urinary urgency, Salivation
*Drug of choice in emergency lowering of intraocular pressure (glaucoma)
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Neostigmine(Prostigmin) & Physostigmine(Generics)
- Class: Indirect-Acting Cholinergic Agonist
- MOA: Stimulate muscarinic and nicotinic sites
- Therapeutic Uses: Stimulation of the bladder and GI tract. Antidotes for overdoses of anticholinergic drugs like Atropine, antipsychotic drugs, antidepressants, tubocurarine. Treatment of Myasthenia gravis(deterioration of Nmreceptors at the neuromuscular
Side Effects: Diarrhea, Diaphoresis(sweating), Miosis, Bronchospasm, Urinary urgency, Salivation
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Atropine
- MOA: High affinity for muscarinic receptors
- Therapeutic Uses: Mydiratic effects, antispasmodic effects(relaxes GI and bladder), antisecretory effects before surgery and in asthma or COPD, bronchdilating effects and an antidote for cholinergic agonists
- Side effects: blurred vision, dry mouth, constipation, urinary retention, drowsiness, tachycardia
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1)Tubocurarine(generics),
2)atracurium(Tracrium*)
3)Rocuronium (Zemuron*)
- Class: Neurumuscular Blocking Drugs (somatic)
- MOA Block cholinergictransmission betwenen moter ner endings and nicotinic receptors
- Therapeutic Uses: helpful (adjuvent) drug used in surgery to relax muscle
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Epinephrine
- Class: Direct acting adrenergic agonist
- MOA: interacts with both a and b receptors
- Therapeutic Uses: At low doses vasodilation b predominates. at high doses vasoconstriction a is strongest...Acute asthma
- Side affects:cardiac arrythmias headace hyperactivity
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Noraepinephrine
- Class: Directacting adrenergic agonists
- MOA:binds with a1, a2, b1
- Therapeutic uses: treatment of shock
- Side affects:cardiac arrythmias headace hyperactivity
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Isoproterenol
- Class: Direct acting adrenergic agonist
- MOA: interacts with both b1 and b2 receptors
- Therapeutic Uses: As bronchodilator in asthma & as cardiac stimulant
- Side affects:cardiac arrythmias headace hyperactivity
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Dopamine
- Class: Direct acting adrenergic agonist
- MOA: Interacts with b1/dopaminergic
- Therapeutic uses: treatment of shock
- Side affects:cardiac arrythmias headace hyperactivity
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Dobutamine
- Class: Direct acting adrenergic
- MOA: acts on b1
- Therapeutic Uses: treatment of congestive heart failure
- Side affects:cardiac arrythmias headace hyperactivity
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Phenylephrine
- Class: Directs acting adrenergic
- MOA: acts on a1
- Therapeutic Uses: nasal decongestant
Side affects:cardiac arrythmias headace hyperactivity
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Metaproterenol
- Class: Direct Acting adrenergic agonist
- MOA: stimulates b2>b1 receptors
- Therapeutic Uses: treatment of bronchospasm
- Side affects:cardiac arrythmias headace hyperactivity
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Terbutaline and Albuterol
- Class: Direct acting adrenergi agonist
- MOA: stimulates B2 receptors
- Therapeutic Uses: treatment of bronchospasma and premature labor
- Side affects:cardiac arrythmias headace hyperactivity
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Ephedrine
- Class: Mixed action adrenergic agonists
- MOA: releases stored noraepinephrine from nerve endings. Directly stimulates both a and b receptors and CNS.
- Therapeutic uses: treatment of asthma
- Side affects:cardiac arrythmias headace hyperactivity
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Phentolamine(Regitine)
- Class: adrenergic antagonists
- MOA: blocks a1 and a1
- Therapeutic Uses: used in pheochromocytoma(adrenal tumors)
- Side affects: Hypotension, Bradycardia
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Terazosin(Hytrin) & Doxazosin(cardura)
- Class: adrengic antagonists
- MOA: Blocks a1
- Therapeutic uses:for benign prostatic hypertrophy
- Side affects: Hypotension, Bradycardia
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Tamsulosin (Flomax)
- Class: adrenergic antagonist
- MOA: blocks a1A receptor
- Therapeutic uses: helps urine flow in bladder
- Side affects: Hypotension, Bradycardia
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Propranolol(inderal)
- Class: adrenergic antagonist
- MOA: Competitively blocks b1 and b2 receptors
- Therapeutic uses: Hypertension, angina pectoris
- Side effects: Hypotension, bradycardia
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Atenolol(tenormin) & Metoprolol (lopressor)
- Class: adrenergic antagonist
- MOA: competitively blocks b1 receptors(cardioselective)
- Therapeutic uses: hypertension
- Side effects: Hypotension, bradycardia
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Pindolol (Visken)
- Class: adrenergic partial agonist as blockers
- MOA: weakly stimulates both b1 and b2 receptors, but inhibit stimulation by epinephrine and norepinephrine, reesulting in a much more diminished effect.
- Therapeutic uses: hypertension
- Side effects: Hypotension, bradycardia
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Labetolol(Normodyne)
- Class: adrenergica partial agonist as a blocker
- MOA: blocks b1,b2 receptors and a1 receptors
- Therapeutic uses: hypertension
- Side effects: hypotension, bradycardia
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cromolyn(Intal)
- Class: Direct acting adrenergic agonists with B2 activity
- MOA: inhibits the release of histamine from mast cells
- Therapeutic uses: Mild asthma
- Side effect
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Ipratropium(atrovent)
- Class: Cholinergic antagonists
- MOA: Blocks muscurinic receptors
- TherapeuticUses: Emphysema/asthma
- SideEffects: cough, dizziness, drymouth
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metroprolol(lopressor)
- Class: beta adrenergic antagonist
- MOA: blocks beta receptors on sympathethic nerves
- Therapeutic Uses: reduces force of contraction of the heart therby lowering drug pressure
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salmeterol(serevent)
- Class: Direct acting adrenergic agonists with b2 activity
- MOA: it is a broncho dilater that focuses on b2
- Therapuetic uses: asthma reatment
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Beclemethasone(Beclovent), Triamcinolone(Azmacort), Flunisolide
- Class: CORTICOSTEROIDS
- MOA:decrease number of cells involved in airway inflammation macrophages and basophils
- Therapeutic uses: allerginic rhinitis asthma
- Side effects:burning itching irritation
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Theoplylline(aminophylline)
- Class:direct acting agonists b2 activity
- MOA: relaxes smooth muscle of broinchioles
- Therapeutic uses: Asthma treatment
- Side effects: burining itching irritation
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