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Glucagon

  1. Class
    Hormone and antihypoglycemic
  2. Description
    Recombinant DNA product from pancreatic alpha cells used to increase blood glucose levels.
  3. Mechanism of Action

    • Causes breakdown of stored glycogen to glucose

    • Inhibits synthesis of glycogen from glucose

    • Increases blood glucose levels

    • Smooth muscle relaxant

    • Exerts positive inotropic effects on heart

    • Decreases renal vascular resistance

  4. Onset of Action

    • Onset:Varies

    • Peak:Varies

    • Duration:Varies

    • Half-Life:Varies

  5. Indications

    • Hypoglycemia, Calcium Channel Blocker Overdose

    • B-blocker overdose

    • Food impaction in esophagus

  6. Contraindications
    Hypersensitivity to drug
  7. Precautions

    • Only effective if enough glycogen is stored in liver

    • Caution in pts with history of cardiovascular or renal disease

  8. Side Effects:
    Dizziness, headache, hypotension, nausea, vomiting
  9. Adult Dose

    • 0.25-0.5 units IV

    • If no IV access, 1 mg glucagon IM

  10. Pedi-Dose
    0.03 mg/kg
  11. Max Dose
    One dose
  12. Route
    IV/IO/IM/SQ
  13. How Supplied
    Powder vials/ pre-mixed vials, 1mL vials
Author
RLESLIE
ID
90827
Card Set
Glucagon
Description
Glucagon
Updated

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