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Watson-Crick
- 1. 2 antiparallel chains, form right-handed double helix
- 2. Sugar Phospate outside, bases inside
- 3. 3.4A bases 10 per turn
- 4. Diameter is 20A
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Supercoiling Advantages
- First, a supercoiled DNA molecule has a morecompact shape than does its relaxed counterpart.
- Second, supercoiling may hinderor favor the capacity of the double helix to unwind and thereby affects theinteractions between DNA and other molecules.
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Annealing
Opposite of melting or denaturation, spontaneous reassociation of separated DNA to form double helix
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DNA Forms
- A-DNA: less hydrated, wider and shorter, base pairs are tilted rather than perpendicular, still right handed
- B-DNA: Watson Crick
- Z-DNA left handed , phosphoryl groups of backbone ar zigzagged.
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Cisplatin
chemotherpy drug, disrupts DNA structure, prevent access to DNA repair enzymes leading to apoptosis
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anticipation
children of affected parent show symptoms of disease at earlier age than parent
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