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AMIODARONE
Antidysrhythmic
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TRADE NAME
Cordarone, Pacerone
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DESCRIPTION
Acts directly on myocytes to inhibit beta1 and alph1 receptors.
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ACTIONS
- 1. Prolongs duration of the action potential
- 2. Prolongs refractory period
- 3. Relaxes vascular smooth muscle
- 4. Reduces peripheral vascular resistance
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INDICATIONS
Amiodarone is used to treat life threatening ventricular and supraventricular dysrhythmias
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CONTRA
- Known Hypersensitivity
- Cardiogenic shock
- Severe sinus bradycardia
- Advanced AV block
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SIDE EFFECTS
- 1. Cardiogenic shock
- 2. Brady dysrhythmias
- 3. Muscle weakness
- 4. Dizziness, vomiting
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ADMINISTRATION
- IV/IO:
- 300 mg push, repeat X1 in 3-5 min
- Perfusing VT:
- 150 mg over 10 min followed by a 1 mg/min over 6 hours. Max 2g/day
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ONSET/DURATION
Rapid, long elimination creates high risk of toxicity
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