-
this occurs when pathogenic microorganisms penetrate the host defense, enter the tussues and multiply
infection
-
this occurs when the cumulative effects of the infection damage or disrupt tissues and organs
disease
-
infectious disease is caused by:
microbes ro their products
-
sites that harbor known normal biota include:
- skin
- upper respiratory tract
- parts of the gastrointestinal tract
-
normal biota can fluctuate with:
- general health
- age
- variations in diet
- hygiene
- hormones
- drug therapy
-
this occurs when normal biota interfere wiht the establishment of intruder microorganisms
microbial antagonism
-
this type of infections are caused by biota that are already present in the body
endogenous infections
-
these are normally sterile during embryonic and fetal development and remain essentially germ-free until just before birt
uterus and its contents
-
a microbe whose relationship with its host is parasitic and results in infection and disease is termed:
pathogen
-
true pathogens are also known as these and are capable of causing disease in healthy persons with normal immune defenses
primary pathogen
-
refers tho the severity of disease that can be caused by a particular microbe
virulence
-
any characteristic or structure of the microbe that contributes to injurty of the host is known as:
virulence factor
-
this is the route by which mircrobe enters the tisssues of the body
portal of entry
-
this type of a source of an infectious agent can originate from a source outside of the body
exogeneous
-
this type of source of an infectious agent can already be existing on or in our body
endogeneous
-
types of portal of entry:
- skin
- gi tract
- respiratory tract
- urogenital tract
-
the sites of entry for skin:
-
the portal of entry for GI tract are:
contained in food, drinks or other ingested substances.
-
pathogens that enter the GI tract are adapted to :
- survive deigestive enzymes
- abrupt pH changes
-
the respiratory portal of entry occurs here:
- oral cavities
- nasal cavities
-
the extent to which an agent is carried into the respiratory tree is based on:
based primarily on its size. in general, small cells and particles are inhaled more deeply than larger ones
-
this is an inflammatory condition of the lung that can occur when pathogens are inhaled into the lower regions of the respiratory tract
pneumonia
-
the urogenital tract is the portal of entry for:
pathogens that are contracted by sexual means. STD account for an estimated 4% of insections worldwide
-
not all urogenital infections are STDs some are caused by:
- displaced organisms such as UTI
- opportunistic overgrowth of normal biota known as Yeast
-
S.T.O.R.C.H
pathogens that infect during pregnancy and birth
- Syphilis
- Toxoplasmosis
- Other diseases (hepatitis B AIDS chlamydia)
- Rubella
- Cytomegalovirus
- Herpes simplex virus
-
Complications from STORCH:
- spontaneous abortion
- congenital abnormalitites
- brain damage
- prematurity
- stillbirths
-
this is the minimum number of mircrobes required for infection to occur. numbers below the ID will generally not cause an infection
Infectious Dose
-
pathogens attach to the host through different methods of:
adhesion
-
some mechanisms of adhesion include:
- fimbrae
- surface proteins
- capsules
- receptor
- hooks and barbs
- (firm attachment is necessary because the body has so many mechanisms for flushing microbes and foreign materials from it's tissues)
-
microbes can survive this by using a number of virulence factors such as leukocidins, capsules or slimes
antiphagocytic factors
-
virulence factors are adaptations that microbes use to invade and establish themselves in the host. these factors include:
- exoenzymes~mucinase and hyaluronidase( digest hyaluronic acid)
- toxins ~ endotoxin and hemolysins (that disrupt the cell membrane of RBC)
-
the host's exessive or inappropriate response to a microorganism cuases much of the damage in:
microbial disease
-
occurs when enzymes, toxins an dother pathogens lead to cell and tissue death
necrosis
-
this type of infection occurs when a microbe enters the body and remains confined to a specific tissue
localized infection
-
this type of infection is one that spreads to several sites and tissue fluids, usually through the bloodstream
systemic infection
-
this type of infection occurs when an infectious agent breaks loose from a local infection and is carried into other tissues
a focal infection
-
this occurs when toxins are secreted by microbes and are carried by the blood to the target tissue
toxemia
-
this type of infection occurs when several agents establish themselves simultaneously at the infection site, also known as plolymicrobial
a mixed infection
-
a primary infections occurs first which then can lead to this:
- secondary infection
- ex: checkenpox as a primary infection which is complicated by staphococcus aureas, which is the secondary infection
-
infections that occur rapidly with severe but short-lived effects are knows as:
acute infection
-
infections that progress and perist over a long period of time are known as:
chronic infection
-
this is any objective evidence as noted by the observer, such as bacteria being found in the spinal fluid when tested in the laboratory
sign
-
this is the subjective evdience of disease as sensed by the patient; this could include a headache in a patient with meningitis
sympton
-
signs and symptoms of inflammation include:
- edema (accumulation of fluid)
- granulomas
- abcesses (which are walled-off collections of inflammatory cells and microbes in the tissues)
- lymphadenitis (swollen lymph nodes)
-
the site of infection or disease that is seen on the skin is known as:
lesions
-
signs of infection in the blood include:
- leukocytosis (an increase in the level of WBC)
- leukopenia (decrease in WBC)
- septicemia (which microorganisms are mutliplying in the blood)
- bacteremia or viremia (which bacteria or viruses are present in the blood but are not necessarily multiplying)
-
an infection that shows no apparent symptoms is known as
asymptomatic infection
-
this is the method by which pathogens leave the host
portal of exit
-
portal of exit includes:
- respiratory tract
- skin scales
- fecal exit
- the urogenital tract
- blood
-
this occurs when an infectious agen retreats into a dormant state
latency
-
this is long term or permanent damage to tissues or organs that can occur due to infectious disease
sequelae
-
this is the primary habitats in the natural world from which a pathogen originates
reservoir
-
these carriers are infected but show no symptoms
asymptomatic carriers
-
these carriers spread the infectious agent during the incubation period
incubation carriers
-
these carriers shelter the infectious agent for a long period of time
chronic carriers
-
these carriers are of great concern during patient care
passive carriers
-
this is a live animal that transmits an ifectious agent from one host to another
vector
-
this vector actively participates in a pathogen's life cycle
biological vector
-
this vector merely transports infectious agents without being infected
mechanical vector
-
an infectious agen that is indgenous to animals but can be transmitted to humas is known as
zoonosis
-
a disease is considered this when an infected host can transmit the infectious disease; the disease is known as contagious if it is very easy to pass from person to person
communicable
-
this is when the infectious disease doese not arise through the transmission of the infectious agent from host to host
noncommunicable
-
this type of transmission occurs from one infected individual to another
horizontal transmission
-
this type of transmission occurs when infection passes from parent to offspring
verical transmission
-
this type of transmission occurs when microbes are passed from one individual to another through contact with skin or mucous membranes
contact transmission
-
this type of transmission occurs when an infectious agent is passed to an intermediate conveyor and from there to another host
indirect transmission
-
this is an inanimate material commonly used by humans that can transmit infectious agent
vehicle
-
this is an inanimate object that harbors and transmits pathogens
fomite
-
these are dried microscopic residues created when pellets of mucus and saliva are ejected from the mouth and nose
droplet nuclei
-
these are suspensions of fine dust or moisture particles in the air tha tcontain live pathogens
aerosols
-
this is a type of infection that are infectious disease that are acquired or develop during a hospital stay
nosocomial infections
-
the most common nosocomial infections involve:
- urinary tract
- respiratory tract
- surgical incisions
-
this is the study of the frequency and distribution of disease
Epidemiology
-
this is called when disease must be reported to the authorities
notifiable or reportable disease
-
the total number of cases of of a disease in a certain area and time period
prevalence
-
in epidemiology, the number of new cases of a desease occurring during a period
incidence
-
the number of persons who have died as athe result of a particular cause or due to all causes, expressed as a numerator, with the denominator being some unit of population
mortality rate
-
the number of persons afflicted with an illness under question or with illness in general, expressed as a numerator, with the denominator being some unit of populatioin
morbidity rate
-
a diseased condition
morbidity
-
a native disease that prevails continuously in a geographic region
endemic disease
-
a sudden and simultaneous outbreak or increase in the number of cases of disease in a community
epidemic
-
description of a disease that exhibits new cases at irregular intervals in unpredictable geographic locales
sporadic
-
a disease afflicting an increased proportion of the population over a wide geographic area (often worldwide)
pandemic
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