Warm Reacting Ag System

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Discover of the Kidd System

Discovered in pregnant woman in 1951 & 1953 because of HDN.
Clinical Significance of Kidd System
- IgG Antibody
- Causes delayed HTRxn and HDN
- Transfusion reaction sever as well as delayed.
Pacific Islanders have what, Kidd?

Jk Silent Allele
Kidd Antigen Structure
- 389 Amino Acids
- Multipass 10 membrane passes
Kidd Antigen responsible for the transport of what?
- Urea
- People with null phenotype do not concentrate urine well.
Jka and Jkb are what dominant?

Co-Dominant
Kidd has how many genes and where?

4 Allelic genes on Ch#18
What is the Kidd Null phenotype?
- Jk
- Silent Allele
- Discovered in 1959
JK (a- b+)
What is genotype?
And percent in population
- Jkb+ Jkb+ or Jkb+ Jk
- Whites: 23
- Blacks: 8
- Asians: 27
Inhibitor gene for Kidd

In (JK)
JK (a+ b-)
What is genotype?
and percent in population?
- Jka+ Jka or Jka+ Jk
- Whites: 26
- Blacks: 51
- Asians: 23
JK (a+b+)
What is genotype?
- Jka+ Jkb+
- Whites: 50
- Blacks: 41
- Asians: 49
JK (a-b-)
What is genotype?
Percent in population?
- Jk Jk or In (Jk)
- Polynesians: 0.9
- Blacks whites and asians: Extremely Rare
Kidd Antibodies
- Anti Jka
- Anti Jkb
- IgG
- React best in AHG Phase
- Complement dependant.
- Storage Weakens Ag
Anti Jka and Jkb react best in what phase?
- AHG
- Complement Dependant
What Kidd Ab is most common?
What percent lack antigen?
- Jka
- 25% of whites negative for Jka
- 9-10% of blacks negative for Jka
Enzymes do what to Jka and Jkb reaction?

Enhance
Reminder
Jka and Jkb BINDS COMPLEMENT
- Reminder
- Jka and Jkb BINDS COMPLEMENT

Author

Anonymous

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Warm Reacting Ag System

Description

Immunohematology Warm Reacting Ag System

Updated

2011-06-07T19:57:17Z

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