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SFOS 70
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Describe Swartz-Barter Syndrome
Inappropriate ADH secretion
Absent of normal stimuli
Causes of Inappropriate ADH secretion
Hypothalamic inpairment causing a change in set point of ADH release
Faulty stimuli from peripheral volume receptors (left atrium)
Secretion of ADH by non-hypothalamic tissue
Certain drugs which enhance ADH effect (some chemotherapeutic agents)
What is the principle consequence of excess ADH and how does it happen?
Hyponatremia
With increased water conservation, glomerular filtration is increased
Renin is suppressed, decreasing aldosterone, decreasing sodium reabsorption
ANH secretion is stiulated, decreasing sodium reabsorption
What are the symptoms of hyponatremia
Headaches
Drowsines/weakness
Stupor
Coma
Seizures
What are the roles of oxytocin
Expulsion of the fetus and placenta
Milk ejection (nipple stimulation leads to oxytocin release, which contracts myometrium)
What are the roles of Prolactin?
Lactogenesis
Mother/baby orientation (CNS)
What are the endocrine functions of the hypothalamus?
Cardiovascular regulation
Thermoregulation
Food intake
Sleep/wake/circadiam
Emotionality
Osmoregulation
Respiration regulation
Pituitary regulation
What vascularly connects the hypothalamus to the pituitary?
Hypophyseal Portal System
Allows hypothalamic hormones to control anterior pituitary function
What are the hypothalamic hormones?
Thyrotropin Releaseing Hormone (TRH)
Gonadotropin Releasing Hormone (GnRH)
Somatostatin/tropin Release Inhibiting Factor (SRIF)
Growth Hormone Releasing Hormone (GRH)
Corticotropin Releasing Hormone (CRH)
Prolactin Inhibiting Factors
Prolactin Releasing Hormone (PRH)
Melanocyte Stimulating Hormone Releasing Factor
Melanocyte Stimulating Hormone Inhibiting Hormone
Action of Thyropropin Releasing Hormone
Increase TSH
Increase Prolactin
Action of Gonadotropin Releasing Hormone
Increase LH
Increase FSH
Action of Somatostatin/tropin Release Inhibiting Factor
Decrease GH
Decrease TSH
Action of Corticotropin Releasing Hormone
Increase ACTH
Increase B-END
Increase B-LPH
Characteristics of hypothalamic hormones
High potency
Short biologic half life
Storage in axon terminals at primary capillary plexus
How might antipsychotic drugs which block dopamine receptors influence endocrine function
Cause hyperprolactinemia
Define Neuroendocrine Transducer
Neuron that secretes hypothalamic hormone in response to electical signal
Short loop negative feedback
Pituitary hormone acts on brain to inhibit its own secretion
Long loop negative feedback
Hormone produced by target gland inhibits pituitary hormone release
Author
zf2010
ID
89636
Card Set
SFOS 70
Description
SFOS 70
Updated
2011-06-07T17:18:17Z
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