Oral Candida.txt

  1. What species cause candida infections?
    • Commensal organisms, that are opportunistic pathogens.
    • Most common C.albicans
    • Others C.Glabrata, Tropicalis, Krusei.
    • Theses more common in immunosuppressed and neutropenic pts.
  2. Local predisposing factors?
    • Denture wearer
    • Poor denture hygiene/OH
    • Smoker
    • Mucosal trauma
    • Local drugs e.g. steroid inhaler
    • Xerostomia (drugs, SS, radio, diabetes)
  3. Systemic predisposing factors?
    • Age -extremes (newborn/elderly)
    • Drugs - AB, steroids
    • Immunodef/compromised
  4. Types of candida infections, classified as ACUTE and CHRONIC name them:
    • Acute -
    • A. Pseudomembranous candidosis
    • A. Atrophic candidosis
  5. Chronic -
    • C. atrophic
    • C. Mucocutaneous
    • C. hyperplastic
  6. What does Acute Pseudomembranous candidosis look like?
    • Soft, friable, creamy white plaque on mucosa
    • Can be wiped off, leaves an erythematous base
  7. What investigation would you do, what would you find? Acute Pseudomembranous candidosis:
    Swab, stained smear will show yeasts, hyphae, leukocytes, debris
  8. Cause of Acute Atrophic Candidosis?
    • Long term steroid/AB
    • Pts with HIV
  9. What does Acute Atrophic Candidosis look like?
    • Patchy red mucosal macules due to candida.
    • Painful
  10. Chronic atrophic candidosis fts?
    • Denture wearers (upper), ortho appliance - continual wear, ill fit, porosity of MMA harbours species
    • Smokers
    • Asymptomatic
    • Erythema of mucosa
  11. Dx of Chronic atrophic candidosis
    • Clinical Dx
    • May need to exclude Diabetes.
  12. Chronic Mucocutaneous candidosis (CMC)?
    • Group of rare syndromes in which there is persistent mucocutaneous candidosis that responds poorly to topical Tx.
    • Skin, nails, mucosa
    • Can be sporadic or have familial assoc.
    • One type is assoc with autoimmune endocrinopathies
  13. Chronic hyperplastic candidiasis characterised by:
    • Persistent white lesion, tough adherent plaque
    • Cannot be scraped off
    • Can have homogenous and non-homogenous areas, speckled
  14. Chronic hyperplastic candidiasis histopathology?
    • Parakeratosis
    • Chronic intra epi inflammation
    • Fungal hyphae invading superficial layers of the epi
  15. Malignant change of Chronic hyperplastic candidiasis?
    • 30% get dysplasia.
    • May become carcinomas
    • Depends on risk factors, appearance (speckled), degree dysplasia
  16. Chronic hyperplastic candidiasis management?
    • Risk factors
    • Antifungals
    • Excision.
  17. What other lesions may involve candida species?
    • Median Rhomboid Glossitis
    • Angular Chelitis
Card Set
Oral Candida.txt
candidal infections of mouth