Amiodarone

Antidysrhymic

Cordarone, Pacerone

Acts directly on myocytes to inhibit beta1 and alpha1 receptors

1. Prolongs duration of the action potential

2. Prolongs refractory period

3.relaxes vascular smooth muscle

4. Reduces peripheral vascular resistance

Amiodarone is used to treat life threatening ventricular and supraventricular dysrhthmias.

Known Hypersensitivity

Cardiogenic shock

Severe sinus bradycardia

Advanced AV block

1. Cardiogenic Shock

2. Brady dysrhythmias

3. Muscle weakness

4. Dizziness, Vomitting

• ADULT DOSE:
• IV/IO arrest 300mg repeat x1 in 3-5 min
• Perfusing VT : 150mg over 10 min follwed by 1mg/min over 6hrs

Rapid: long elemination creates high risk of toxicity