Pancuronium bromide is a derivative of curare and is used to provide skeletal muscle relaxation to facilitate endotracheal intubation.
Mechanism
of Action
Pancuronium bromide competes with acetylcholine for cholinergic receptors sites on the postjuctional membrane. This results in paralysis of muscles fibers innervated by the occupied neuromuscular junction. It does not cause an initial depolarization wave as does Succinylcholine.
Onset
of Action
Onset:30-45 sec
Peak:3-5 min
Duration:30-60 min
Half:Life:2 hours
Indications
Used to achieve temporary paralysis to facilitate endotracheal intubation when muscle tone, seizures, or laryngospasm prevent it.
Contraindications
Hypersensitivity to drug.
Precautions
Should have a skilled person in intubation, emergency resuscitation equipment and drugs present, Paralysis occurs in 3-5 min and lasts for approximately 60 min.