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Hydrocortisone, Methylprednisolone
Trade Name
Cortisone, Prednisone (respectively)
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Hydrocortisone, Methylprednisolone
Class
Corticosteroid
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Hydrocortisone, Methylprednisolone
Mechanism of Action
- Replaces absent glucocorticoids
- Suppresses acute and chronic inflammation
- Immunosuppressive effects
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Hydrocortisone, Methylprednisolone
Indications
- Anaphylaxis
- Asthma
- Spinal Cord Injury
- Croup
- Elevated Intracranial Pressure (prevention and treatment)
- Adrenal insufficiency
- As an adjunct to treatment of shock
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Hydrocortisone, Methylprednisolone
Contraindications
Hypersensitivity to product
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Hydrocortisone, Methylprednisolone
Adverse Reactions
- Hypertension
- Sodium and water retention
- GI bleeding
- TB
- None from single dose
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Hydrocortisone, Methylprednisolone
Drug Interactions
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Hydrocortisone, Methylprednisolone
How Supplied
- Hydrocortisone: 100 mg/ 2 ml vials
- Methylprednisolone: 125 mg/2 mg and 40 mg/2 ml vials
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Hydrocortisone, Methylprednisolone
Dosage and Administration
Adult
- Hydrocortisone: 2 mg./kg. IV bolus to maximum of 100 mg
- Methylprednisolone: 2 mg./kg/ IV bolus to maximum of 125 mg
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Hydrocortisone, Methylprednisolone
Dosage and Administration
Pediatric
(None Listed)
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Hydrocortisone, Methylprednisolone
Duration of Action
- Onset: Minutes to Hours (depending on indication).
- Peak effects: 8-12 hours
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Hydrocortisone, Methylprednisolone
Special Considerations
Protect medication from heat
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