shosh: immuno factoids

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IL1
- Secreted by macrophages
- Triggers acute inflammation
- Activates endothelium to express adhesion molecules
IL2
- Secreted by Th cells
- Stimulates T cell growth
- Upregulates its own receptors (autocrine action)
IL3
- Secreted by activated T cells
- Supports growth and differentiation of BM stem cells, similar to CSF
IL4
- Secreted by Th2 cells
- Promotes B cell growth
- Triggers class switching to IgE
IL5
- Secreted by Th2 cells
- Promotes B cell differentiation
- Triggers class switching to IgA
- Stimulates production and activation of eosinophils
IL6
- Secreted by Th cells and macrophages
- Stimulates production of acute phase reactants
IL8
- Secreted by macrophages
- Major chemotactic factor for neutrophils (along with C3a)
IL10
- Secreted by Treg cells
- Inhibits activated T cells
IL12
- Secreted by B cells and macrophages
- Activates NK and Th1 cells
IFNgamma
- Secreted by Th1 cells
- Stimulates macrophages
- Inhibits Th2 cells
- Involved in granuloma formation
TNF
- Secreted by macrophages
- Acute phase reactant--causes leukocyte recruitment and vascular leak
- Mediates septic shock
Chemotactic for neutrophils
- C5a
- IL8
- LTB-4
- Kallikreini
Igs that activate complement

IgG, IgM
C3b

Opsonization
C3a, C5a

Anapylaxis
C1 esterase deficiency

Hereditary angioedema (captopril is a no-no)
C3 deficiency
- Recurrent pyogenic and respiratory tract infections
- Increased susceptibility to type III HS reactions
C5-8 deficiency

Susceptibility to neisseria bacteremia
Deficiency in DAF (decary-accelerating factor)
- Complement-mediated RBC lysis
- PNH
IFN alpha and beta

Induce production of a ribonuclease that degrades viral mRNA
CD40-CD40 ligand interaction

Class switching and immunological memory

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shosh114

88526

Card Set

shosh: immuno factoids

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Updated

2011-05-31T10:39:34Z

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