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Class
Sympathetic agonist
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Description
Isoproterenol is a synthetic catecholamine. It acts primarily on Beta adrenergic receptors.
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Mechanism of Action
A potent, synthetic catecholamine that increases HR in bradycardia that are refractory to Atropine. Increases cardiac contractile force, causes bronchodilation.
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Onset of Action
- Onset: Immediate
- Peak: <1min
- Duration: Varies
- Half-Life: <1.5min
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Indications
Bradycardias refractory to Atropine
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Contraindications
Should not be used to increase blood pressure in cardiogenic shock.
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Precautions
Ventricular irritability, can be deactivated by alkaline solutions, should be used with caution for recent MI, external pacing, if available, should be used instead of isoproterenol. But may be going back to "meds" to increase rate to TCP no being as effective as once thought.
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Side Effects
Headache, palpitations, tachydysrythmias, tremors.
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Adult Dose
1mg should be placed in 500ml of D5W and then slowly infused at 2-10ug/min and titrated until the desired rate is obtained or PVC occur.
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Routes of Administration
IV/IO
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