Isoproterenol (Isuprel)

Sympathetic agonist

Isoproterenol is a synthetic catecholamine. It acts primarily on Beta adrenergic receptors.

A potent, synthetic catecholamine that increases HR in bradycardia that are refractory to Atropine. Increases cardiac contractile force, causes bronchodilation.

• Onset: Immediate
• Peak: <1min
• Duration: Varies
• Half-Life: <1.5min

Bradycardias refractory to Atropine

Should not be used to increase blood pressure in cardiogenic shock.

Ventricular irritability, can be deactivated by alkaline solutions, should be used with caution for recent MI, external pacing, if available, should be used instead of isoproterenol. But may be going back to "meds" to increase rate to TCP no being as effective as once thought.

Headache, palpitations, tachydysrythmias, tremors.

1mg should be placed in 500ml of D5W and then slowly infused at 2-10ug/min and titrated until the desired rate is obtained or PVC occur.

0.1ug/kg/min

10ug

IV/IO

Vials