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Indications for duloxetine?
- Major depression
- Generalised anxiety disorder
- Painful diabetic peripheral neuropathy
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Precautions of duloxetine?
- seizure history
- bipolar - can induce mania
- Treatment within 14 days of ceasing a MAOI = contraindicated
- renal impairment
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Adverse effects of duloxetine?
nausea, dry mouth, constipation, decreased appetite, sweating, insomnia,
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Dosage of duloxetine?
- depression - 60mg daily
- diabetic neuropathy - 60mg daily
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counselling of duloxetine?
- Take with food to minimise stomach upsets.
- Do not open, crush or chew capsules.
- Be careful driving or operating machinery until you know how duloxetine affects you.
- Do not stop taking this medicine suddenly unless your doctor tells you to.
- increased suicidal thoughts and behaviour can occur soon after starting
- antidepressants, particularly in young people; monitor patients
- frequently and carefully early in treatment
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Precautions of venlafaxine?
- hypertension - may be exacerbated by venlafaxine
- bipolar - may provoke manic episode
- seizure history
- serotonin toxicity
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adverse effects of venlafaxine?
nausea, vomiting, anorexia, headache, sweating, rash, anxiety, dizziness, fatigue, hypertension (dose-related), tremor
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Dose of venlafaxine?
75 mg once daily, increasing to 150 mg once daily if required.
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Counselling of venlafaxine?
- Take with food to minimise stomach upsets.
- Do not open, crush or chew capsules, or put them in water.
- Be careful driving or operating machinery until you know how venlafaxine affects you.
- Do not stop taking this medicine suddenly unless your doctor tells you to.
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