-
_____ is predominantly an infection of sexually active individuals, usually men.
urethritis
-
The symptoms are pain and burning during urination, and some discharge may occur at the urethral meatus
urethritis
-
Urethritis may be _____ in origin or it may be caused by Chlamydia trachomatis or Ureaplasma urealyticum
gonococcal
-
Bacterial infection of the urinary bladder
cystitis
-
bacterial infection of the kidney
pyelonephritis
-
Cystitis and pyelonephritis are more common in ____
women
-
instrumentation (catheterization, cystoscopy), pregnancy, anatomic abnormalities of the genitourinary tract, and diabetes mellitus
UTI risk factors
-
Incidence of cystitis and pyelonephritis increase with ____
age
-
Most UTI's ascend through a _____
portal entry in the urethra
-
____ is the most common isolate in UTI's
E. coli
-
Suprapubic pain, discomfort or burning sensation on urination and frequent urination
common symptoms of UTI
-
Back or flank pain, or the occurrence of a fever suggests involvement of the
kidneys, or prostate
-
Older or debilitated patients with UTI may present with
no symptoms referable to the urinary tract
-
Older or debilitated patients with UTI may present with
fever, altered mental status, hypotension
-
UTI urinalysis may show
WBC's, RBC's and slightly increased protein
-
The presence of at least 10 WBC's/mm(3) of midstream urine by counting chamber is defined as pyuria
pyuria
-
the presence of WBC casts in an infected urine sample indicates the presence of
pyelonephritis
-
Urine for culture should not be obtained from a
catheter bag
-
______ tests are not essential for patients with uncomplicated cystitis unless treatment fails
culture and sensitivity
-
Recurrent UTI's in men should always raise the suspicion for
anatomic alterations of the urinary tract
-
Possible UTI organisms that will not grow on routine culture medium
Chlamydia, N. gonorrhoeae, or Ureaplasma
-
if a UTI is unresponsive to the first course of antibiotics patients should receive
doxycycline or azithromycin
-
empiric therapy for uncomplicated UTI's can be
a short course of amoxicillin, TMP-SMZ, or ciprofloxacin
-
short course therapy is not recommended for
women with a history of UTI's
-
All patients with complicated UTI's should have
repeat urine cultures 1-2 weeks after treatment completion
-
should be performed in all men with UTI (except those with urethritis) because of the high frequency of correctable anatomic lesions in this population
urologic evaluation
-
if a 6 week course of antibiotics active against the bacterial isolate is not effective then the possibility of _____ should be investigated
structural abnormalities or prostatic infection
-
Urine cultures showing bacterial growth in the absence of symptoms
asymptomatic bacteriuria
-
does not need to be treated in otherwise healthy/non-pregnant individuals
asymptomatic bacteriuria
-
The occurrence of pyuria in the absence of bacterial growth on culture of urine
sterile pyuria
-
If this condition occurs in the patient with lower UTI symptoms then chlamydia, gonococcal infections, vaginitis, or herpes simplex infection should be considered
sterile pyuria
-
symptoms of back or perineal pain and fever are common with
prostatitis
-
Acute prostatitis may be caused by gonococcus but is most often caused by
gram-negative bacilli
-
Prostatic abscesses can be
drained with ultrasound guidance
-
Should be suggested in men with recurrent UTI
chronic prostatitis
-
Treatment of _____ is hampered by poor penetration by most antimicrobials
chronic prostatitis
-
fever, flank pain, CVA tenderness, N/V
signs and symptoms of upper UTI
-
dysuria, frequency, urgency, suprapubic pain, =/- hematuria
signs and symptoms of lower UTI
-
vaginal d/c or odor, pruritus, dyspareunia, external dysuria (labial pain with urination), but no frequency or urgency
vaginitis
-
dysuria and frequency with no vaginal discharge or irritation is ___ in more than 90% of cases
cystitis
-
presence of WBC casts indicate
upper tract infection
-
common in UTI but not urethritis or cervicitis
hematuria
-
indicates presence of bacteria, more specific than sensitive
nitrites
-
an enzyme made by neutrophils in response to bacteria
leukocyte esterase
-
as a general rule ____ is a UTI occurring in a healthy young nonpregnant woman
uncomplicated acute cystitis
-
-
don't give ____ for acute cystitis
amox-clav
-
first line for acute uncomplicated cystitis
TMP-SMX
-
best course length of antibiotics for uncomplicated UTI
three day short course
-
should be considered as and alternative to TMP-SMX in the treatment of uncomplicated acute cystitis
nitrofurantoin
-
-
big guns used for complicated infections/allergy to TMP-SMX, risk factors for TMP-SMX resistance
fluoroquinolones
-
used to treat symptoms of acute cystitis-is not an antibiotic
phenazopyridine
-
-
An infection occurring in anyone OTHER than a healthy young non-pregnant woman
complicated UTI
-
urine culture is essential with
complicated UTI
-
nonsecretor phenotype
higher risk of UTI
-
strongest risk factor for UTI
frequency of intercourse
-
in postmenopausal women ____ can be an effective prophylaxis because ti leads to an increase of lactobacilli and a decrease in E. coli
intravaginal estriol cream
-
in recurrent UTI ___ evaluation should be done if concerned about structural or functional abnormality of GU tract
urological evaluation
-
when doing a urological evaluation start with
CT or renal US
-
treatment of cystitis in men
7-days of TMP-SMX, trimethoprim, or FQ
-
-
normal color
amber yellow
-
-
normal pH
4.6-8.0 avg 6.0
-
normal protein ___ mg/dL
0-8
-
normal protein ___ mg/24 hr at rest
50-80
-
normal protein ___ mg/24 hr during exercise
<250
-
normal specific gravity adult
1.005-1.030
-
normal specific gravity elderly
values decrease with age
-
normal specific gravity newborn
1.001-1.020
-
normal leukocyte esterase
negative
-
-
-
-
normal urobilinogen ___ Ehrlich unit/mL
0.01-1
-
-
-
normal glucose (fresh specimen)
none
-
normal glucose (24 hr)___mg/day
50-300
-
normal glucose (24 hr)___mmol/day (SI units)
0.3-1.7
-
normal WBC ___ per low-power field
0-4
-
-
-
-
____ infection may cause green urine
Pseudomonas
-
patients with ____ may have the strong sweet smell of acetone
diabetic ketoacidosis
-
Bacteria, UTI, or a diet high in citrus fruits or vegetables may cause
increased urine pH
-
starvation, dehydration, or a diet high in meat products or cranberries may cause
decreased urine pH
-
to prevent or treat urinary calculi from xanthine, cystine, uric acid, and calcium oxalate urine pH should be kept
alkaline
-
to treat urinary calculi from calcium carbonate, calcium phosphate, and magnesium phosphate urine pH should be kept
acidic
-
the combination of proteinuria and edema is known as
nephrotic syndrome
-
probably the most important indicator of kidney disease
proteinuria
-
proteinuria in pregnant women can indicate
preeclampsia
-
a measure of the concentration of particles in the urine
specific gravity
-
used to evaluate the concentrating and excretory powers of the kidneys
specific gravity
-
high specific gravity indicates
concentrated urine
-
low specific gravity indicates
dilute urine
-
when a person is dehydrated one can expect the specific gravity of that person to be abnormally
high
-
Positive results indicate UTI
leukocyte esterase
-
is a screening test for identification of UTI's
nitrites
-
Nitrite test is about ___% accurate
50
-
leukocyte esterase is about ___% accurate
90
-
_____ is usually associated with poorly controlled diabetes
ketonuria
-
can be present in the following conditions; alcoholism, fasting, starvation, high protein diets, isopranol ingestion
ketonuria
-
may occur in acute febrile illnesses, especially in infants and children
ketonuria
-
obstruction of a bile duct by a gallstone will lead to
elevated urine bilirubin
-
bilirubin in the urine will color it
dark yellow or orange
-
by themselves, crystals cause no symptoms until
they form stones
-
stones only produce symptoms when they
obstruct the urinary tract
-
crystals may indicate
the formation of a renal stone
-
occur in the urine of patients with parathyroid abnormalities or malabsorption states
phosphate and calcium oxalate crystals
-
clumps of materials or cells that form in the renal distal and collection tubules, where material is maximally concentrated
casts
-
for ___ to form the pH must be acidic and the urine concentrated
casts
-
conglomerations of protein and are indicative of proteinuria, a few may be present after strenuous exercise
hyaline casts
-
sodium, potassium, chloride, carbon dioxide, BUN, creatinine, glucose, GFR
components of the chem 7 at Duke
-
normal sodium ____ mmol/L
135-145
-
normal potassium ____ mmol/L
3.2-4.8
-
normal chloride ____ mmol/L
98-108
-
normal carbon dioxide ____ mmol/L
21-30
-
normal urea nitrogen ___ mg/dL
7-21
-
normal creatinine ___ mg/dL
0.7-1.4
-
increased BUN is called
uremia
-
decreased renal blood flow
prerenal uremia
-
urea backed up into blood from lower urinary obstruction
postrenal uremia
-
diseases or toxicities that affect glomeruli, renal microvascular or tubules
renal uremia
-
proportional to muscle mass, usually higher in men than women
serum creatinine
-
stable in health at a ratio of 1:10
BUN:creatinine ratio
-
lower in liver disease, starvation, acute tubular necrosis
BUN:creatinine ratio
-
Higher (with normal Cr) in prerenal uremia, high protein diet, GI bleed
BUN:creatinine ratio
-
Higher (with high Cr is called “azotemia”) in renal disease & failure
BUN:creatinine ratio
-
can be caused by preeclampsia, multiple myeloma, temperature extremes, fever, exercise, position, stress
proteinuria
-
main cause of glycosuria
diabetes
-
product of fat breakdown
ketones
-
product of hemoglobin breakdown
bilirubin
-
a few hyaline casts on urinalysis is
normal
-
RBC casts
acute glomerulonephritis
-
WBC casts
acute pyelonephritis
-
epithelial casts
tubular necrosis
-
granular casts
nephrotic syndrome, pyelonephritis
-
waxy casts
tubular atrophy, renal failure
-
bacterial casts
pyelonephritis
-
fatty casts
proteinuria, nephrotic syndrome
-
___ can be estimated by blood level of creatinine
GFR
-
___ indicates level of kidney function
GFR
-
___ calculations do not apply in acute situations or in patients on dialysis
GFR
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