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Indications of CCBs?
- Hypertension
- Angina
- SVT and AF} - verapamil
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Precautions of CCBs?
- myasthenia-like neuromuscular disease
- increased risk of muscle weakness and respiratory depression
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Does dyhydropyridine-induced peripheral odema require diuretic treatment? why or why not?
no, due to risk of volume depletion
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Dose and adverse effects of amlodipine?
dose: 2.5-5mg daily
headache, flushing, peripheral oedema and palpitations
pulmonary oedema, hypotension, tachycardia, chest pain, dyspepsia, constipation, paraesthesia, muscle cramps, rash
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Dose of diltiazem? in HTN and HF?
adverse effects?
HTN - 180-240mg daily
peripheral oedema, rash, headache, dizziness, flushing, nausea, abdominal pain, bradycardia
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Dose of felodipine?
Adverse effects?
5mg daily
headache, flushing, peripheral oedema and palpitationspulmonary oedema, hypotension, tachycardia, chest pain, dyspepsia, constipation, paraesthesia, muscle cramps, rash
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Lercanidipine
C/I's??
Dose?
A/E?
cyclosporin
10mg daily
headache, flushing, peripheral oedema and palpitationspulmonary oedema, hypotension, tachycardia, chest pain, dyspepsia, constipation, paraesthesia, muscle cramps, rash
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Nifedipine
dose?
Uses?
A/E?
10-20mg twice daily, increase to 20-40mg twice daily
CR tablets preferred for angina use
can be used for pre-term labour
headache, flushing, peripheral oedema and palpitationspulmonary oedema, hypotension, tachycardia, chest pain, dyspepsia, constipation, paraesthesia, muscle cramps, rash
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Verapamil
dose?
Issue with dabigatran?
Counselling point?
Adverse effects?
- 80mg two or three times daily upto 160 2-3x daily
- 180-240mg CR
Can increase concentration of dabigatran therefore increase bleeding risk
Counselling: may increase effects of alcohol, swallow CR tabs whole
- peripheral oedema, rash, headache, dizziness, flushing, nausea, abdominal pain, constipation
- gynaecomastia, hepatitis
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