-
pyridostigmine
- carbamate AChEI
- treatment of myasthenia gravis to incr muscle tone
- muscarinic effects: SLUGD
-
prednisone
corticosteriod, immunosuppressant, anti-inflammatory
-
tubocurarine
- nondepolarizing neuromuscular blocking agent
- skeletal muscle relaxant
- competitive inhibitor of ACh
- worst for histamine release, vasodilation that can result in hypotension, decreased GI tract tone, motility
-
atracurium
- skeletal muscle relaxant, intubation
- fewer SE compared to tubocurarine
-
rocuronium
- short-acting nondepolarizing neuromuscular blocking agent
- duration of action still longer than succinylcholine
- very few SE
-
succinylcholine
- very short-acting depolarizing skeletal muscle relaxant
- rapidly hydrolyzed by plasma AChE
-
muscarinic antagonist anti-parkinsonian agents
- trihexyphenidyl
- benztropine
-
Irreversible MAO-B inhibitors for PD
-
COMT inhibitor for PD
entacapone
-
5HT 1B/1D receptor agonist
-
antimigraine agent, ergot derivative
dihydroergotamine
-
verapamil
- Ca++ channel blocker
- cardiovascular conditions
- off-label treatment of migraine
-
topiramate
- anticonvulsant, neuropathic pain med
- NA+, Ca++, GABA effects
- SE: weight loss
-
valproic acid
- anticonvulsant
- seizures, mania, migraine prophylaxis
- may affect GABA, Na+
-
propranolol for neuro symptoms
- non-selective beta-blocker
- migraine prophylaxis
- off label: essential tremor, EtOH withdrawal, performance anxiety
- binds to beta-2 receptor on muscle spindle to control tremor
-
primidone
- anticonvulsant/antiepileptic
- raises seizure threshold - increases duration of GABA channel opening, results in Cl- influx, hyperpolarization, inhibition
-
phenytoin
- anticonvulsant
- treatment of partial seizures
- blocks Na+ channels
-
carbamazepine
- anticonvulsant
- partial seizures, trigeminal neuralgia
- blocks Na+ channels and inhibits sustained repetitive firing
- induces its own metabolism; CYP 3A4, 2C
-
phenobarbitol
- anticonvulsant, barbituate
- treatment of seizures; sedative
- increases open time of GABA channels (diff from benzodiazepines)
- induces CYP 3A4 and 2C
-
mech of barbituates v. benzodiazepans
- barbituate: increase open time of GABA channels
- benzo: increases frequency of GABA channel opening
-
oxcarbazepine
- anticonvulsant
- monotherapy/adjunctive treatment for partial seizures
- blocks Na+ channels
-
lamotrigine
- anticonvulsant
- stabilizes membranes by blocking Na+ channels, less release of glu/asp, decreased seizure frequency
-
levetiracetam
- anticonvulsant
- Na+ channels, kainate receptor blocker
- Prevents hypersynchronization of epileptiform burst firing/propogation of seizure activity
-
zonisamide
- anticonvulsant
- partial seizure treatment
- no effect on GABA, acts on Na+ and Ca++ channels
-
tiagabine
- anticonvulsant
- adjunctive treatment for partial seizures
- enhance GABA uptake, availability @ postsynaptic neuron
-
lorazepram
- benzodiazepine
- anxiety disorders
- IV for status epilepticus
- GABA-A, hyperpolarization
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