-
Definition of acute renal failure
Rapidly deteriorating kidney function (accumulation of nitrogenous waste)
-
Urine output less than 0.5-1cc/kg/hr (400cc/day in adults)
Oliguria
-
Most common cause of acute renal failure
Hypovolemia
-
-
Prerenal cause of ARF
- Hypovolemia, ineffective circulating volumes (sepsis, anaphylaxis, third spacing),
- decreased cardiac output (CHF, mi)
-
What can cause dehydration?
- Vomiting and diarrhea,
- diuretics,
- skin losses (burns)
-
Renal origins of ARF
- Tubulointerstitial,
- glomerular,
- vascular
-
Postrenal origins of ARF
- Ureteral or bladder obstruction,
- urethral obstruction
-
Causes of ureteral or bladder obstruction
- Kidney stones,
- blood clots,
- malignancies,
- prostatic hypertrophy
-
Urethral obstructions
- Strictures,
- phimosis,
- meatal stenosis
-
What lab are you looking at to determine ARF?
Creatinine >1.4
-
Treatment for prerenal ARF
- Volume replacement,
- maximize cardiac output
-
Treatment for renal ARF
- Low dose dopamine,
- mannitol in early rhabdomyolysis,
- dialysis
-
Treatment for postrenal ARF
Relieve obstruction (Foley, ureteral stent, nephrostomy)
-
Signs and symptoms of UTI
- Dysuria,
- frequency,
- urgency,
- hematuria,
- urethral discharge,
- pain (suprapubic, rectal, costovertebral)
-
Most common UTI pathogen
E-coli
-
Safe UTI treatments during pregnancy
Nitrofurantoin
-
Duration of treatment for uncomplicated UTI’s
3 days
-
Duration of treatment of pyelonephritis, pregnant patients with utis, complicated/frequent utis/prior treatment failure
7-14 days
-
Treatment for GC
Ceftriaxone (Rocephin) IM
-
Treatment for Chlamydia
Azithromycin or doxycycline
-
Treatment for trichomonas
Metronidazole (Flagyl)
-
Presentation of acute prostatitis
- Fever,
- malaise,
- back or rectal pain,
- rectal exam reveals swollen/firm/painful prostate
-
Source of acute prostatitis in males<35 yo
GC, chlamydia
-
Source of acute prostatitis in males>35
E-coli, klebsiella, Enterobacter, proteus
-
Treatments for acute prostatitis
Quinolone, Bactrim
-
Presentation of urolithiasis
- Flank pain (abrupt onset, severe, colicky, may radiate to scrotum),
- N/V,
- previous episodes,
- CVA tenderness,
- LQ pain
-
What are some deadly diseases that can mimic presentation for kidney stones?
- AAA,
- appendicitis,
- tuboovarian abscess,
- ectopic pregnancy
-
Any female of childbearing age with abdominal pain gets a work up for what
Pregnancy
-
Modality of choice for evaluation of urolithiasis in pregnant females
Ultrasound
-
Presentation of testicular torsion
- Young men,
- pain with abrupt onset (after exertion, or during sleep),
- severe low abdominal/inguinal canal/scrotum,
- N/V,
- horizontal lie of testicle,
- absence of cremasteric reflex
-
Testicular torsion must be detorsed within __ for salvage
4-6
-
Blue dot sign on translumination of testes is pathognomonic for what
Testicular appendage torsion
-
What is Prehn’s sign and what is it a sign of
- Pain relief with elevation of testicle,
- epididymo-orchitis
-
Treatment for priapism
- Subcutaneous terbutaline/phenylephrine,
- Surgery
-
Inability to retract the foreskin due to fibrous constriction or scar
Phimosis
-
Inability to reduce retracted foreskin over the glans
Paraphimosis
-
What is essential in the immediate treatment of chemical burns to the eye?
Irrigation
-
When should treatment of a chemical burn to the eye begin?
Before arrival at the emergency center
-
If a patient has a chemical burn to the eye with an acidic substance should an attempt be made to neutralized it by adding an alkaline substance
No
-
What should be done after 30 min of irrigation of an eye with a chemical burn?
Check tear ph, if not 7, continue irrigation
-
Bleeding in the anterior chamber of the eye
Hyphema
-
What are some of the general guidelines in the treatment of hyphema?
- Shield eye (no patch),
- bedrest (with b/r privileges),
- elevate head of bed to 30 degrees,
- topical atropine, no aspirin/NSAIDs,
- consider topical steroids,
- monitor intraocular pressure
-
What are some signs and symptoms of a corneal abrasion?
- Sharp pain/foreign body sensation,
- photophobia,
- tearing,
- fluorescein staining,
- conjunctival injection,
- swollen lid
-
When considering a corneal abrasion what should be in your differential?
- Dry eye/recurrent erosion syndrome,
- infectious keratitis (bacterial ulcer, HSV, acanthamoeba, fungal ulcer)
-
What do you include in the work-up of a corneal abrasion?
- Slit lamp exam with fluorescein,
- evert lids to rule out foreign body
-
What is the treatment for a corneal abrasion in a non-contact lens wearer?
- Erythromycin or Polytrim drops,
- cycloplegic agent,
- consider patch
-
What is the treatment for a corneal abrasion in a contact lens wearer?
- Must cover pseudomonas (tobramycin ointment, fluoroquinolone drop),
- cycloplegic agent,
- consider patch
-
When should a corneal abrasion be referred to an ophthalmologist?
- If not healed in 24 hours,
- abrasion related to contact lens wear,
- white corneal infiltrate develops
-
Focal loss of corneal stroma with overlying epithelial defect
Corneal ulcer
-
What is the number one risk factor for corneal infection?
Contact lens wear (overnight, swimming)
-
What is the #2 risk factor for corneal infection?
Trauma, corneal abrasion
-
What should you do if you suspect infectious keratitis?
Call an ophthalmologist
-
What is the treatment for infectious keratitis?
Broad spectrum antibiotic drops
-
What should be included in the workup for central retinal artery occlusion?
ESR for temporal arteritis
-
What is the treatment for central retinal artery occlusion?
Although no treatment has been proven to improve outcome you can try, lowering IOP with topicals, Diamox, anterior chamber paracentesis
-
The immediate treatment for angle closure glaucoma is to lower eye pressure, how is this done?
- Drops (timolol, dorzolamide, brimonidine),
- oral agents (Diamox, isosorbide),
- IV agents (mannitol), h
- old pilocarpine until seen by an ophthalmologist
-
What is endophthalmitis?
- Inflammation of the tissue inside the eye caused by bacteria (coag neg staph, SA, gram -),
- fungi, rarely viruses (Herpes simplex/zoster),
- or protozoa (acanth, toxplasafi),
- and is usually associated with eye surgery
-
What are the symptoms of endophthalmitis?
- Decreased vision,
- pain,
- redness (especially after eye surgery),
- blurred vision (pretty generic)
-
What is the treatment of endophthalmitis?
Injection of intravitreal antibiotics or surgery ASAP
-
What is the most common etiologic agent of viral conjunctivitis?
Adenovirus
-
What is the treatment for viral conjunctivitis?
- Supportive,
- throw out contact lens/case/solution,
- wash sheets/towels,
- wash hands religiously
-
For how long is viral conjunctivitis contagious?
2 weeks
-
Conjunctivitis in an infant, assume what organisms?
Chlamydia and or gonorrhea
-
Gonococcal conjunctivitis requires __ treatment
Systemic
-
Acute, often red, infection of the sebaceous glands at the base of the eyelashes
Hordeolum
-
Chronic, often fibrotic, infection of the sebaceous glands at the base of the eyelashes
Chalazion
-
Treatment for hordeolum/chalazion
- Start conservatively,
- warm compresses,
- erythromycin ointment,
- consider I&D,
- steroids sometimes injected to prevent recurrence
-
Inflammation along the eyelashes/meibomian glands (gritty burning eyes)
Blepharitis
-
Treatment of blepharitis
Warm compresses, lid scrubs, consider erythromycin ointment or doxycycline
-
Blepharitis with ulceration or lash loss consider __
Cancer
-
What are risk factors for retinal detachment?
Myopia, trauma, family history, cataract surgery, detachment in the other eye
-
What will happen to the pressure in an eye affected with a retinal detachment?
May be lower
-
What is significant in the history of a retinal detachment?
Flashes or floaters
-
What is the treatment for periorbital cellulitis?
PO or IV antibiotics
-
Elderly man with history of monocular vision loss, jaw pain, and recent weight loss, what are you suspicious for?
Giant cell/temporal arteritis
-
29 year old woman with multiple sclerosis presents with acute loss of central vision in one eye, and pain with eye movements. What are you suspicious for?
Optic neuritis
-
What is a stye
Acute infection of the oil gland at the lash line that appears as a pustule (aka external hordeolum)
-
Treatment for stye (external hordeolum)
- Warm wet compresses 4x day,
- erythromycin ointment 2x/day for 7-10 days
-
Acute or chronic noninfectious inflammation of the eyelid secondary to meibomian gland blockage in the tarsal plate
Chalazion (internal hordeolum)
-
Why has gentamicin fallen out of favor for the treatment of bacterial conjunctivitis?
High incidence of ocular irritation
-
Presents as monocular or binocular eyelash matting, mild to moderate mucopurulent discharge, and conjunctival inflammation
Bacterial conjunctivitis
-
Presents as a monocular or binocular watery discharge, chemosis, and conjunctival inflammation
Viral conjunctivitis
-
Treatment of viral conjunctivitis
Cool compresses 4x/day, naphazoline/pheniramine drops for conjunctival congestion or itching. Follow up in 7-14 days
-
Endophthalmos is a true __
Ocular emergency
-
How do patients with endophthalmos present?
Pain and visual loss
-
What is the initial empiric treatment for endophthalmos?
Vancomycin and ceftazidime
-
Periorbital cellulitis (preseptal cellulitis)
A superficial infection of the eyelids that does not extend past the orbital septum. The eyelids become warm indurated and erythematous but he eye itself is not involved
-
Orbital cellulitis (postseptal cellulitis)
A potentially sight and life threatening ocular infection deep to the orbital septum, typically as a result of spread from the ethmoid sinuses
-
How should superficial conjunctival abrasions be treated?
- Erythromycin ointment 2x/day for 2-3 days,
- ocular foreign body should be excluded
-
What is the preferred topical ocular anesthetic used when assessing a corneal abrasion?
Proparacaine
-
How will a corneal abrasion appear during fluorescein stain when using cobalt blue light on slit lamp?
It will fluoresce green
-
What is the treatment for a simple corneal abrasion?
- A cycloplegic (cyclopentolate, homatropine) for the pain,
- and a topical antibiotic (tobramycin, erythromycin, bacitracin/polymyxin)
-
What is the antibiotic treatment for a corneal abrasion for a person with contact lenses?
Should include coverage for pseudomonas (ofloxacin or ciprofloxacin)
-
How are superficial corneal foreign bodies removed?
Under slit lamp microscopy with a fine needle, eye spud, or ophthalmic burr. Proparacaine is used (also instilled in the unaffected eye to depress reflex blinking)
-
Who should remove a corneal foreign body deep within the corneal stroma, or in the central visual axis?
An ophthalmologist
-
What do you do for a high risk lid laceration if an ophthalmologist is not immediately available to evaluate and treat?
As long as all sight-threatening lesions have been excluded prescribe oral and topical antibiotics and gentle cold compresses with referral to an ophthalmologist in 24 hours
-
A hyphema should be dilated with __ to prevent pupillary movement from tearing damaged blood vessels
Atropine 1%
-
What orbital walls do blowout fractures commonly involve?
Inferior and medial
-
Which muscle is usually entrapped in a blowout fracture, and what does it cause?
- Inferior rectus muscle.
- May cause restricted movement, resulting in diplopia on upward gaze
-
What must be avoided once a globe injury is suspected?
Any further manipulation or examination of the eye
-
Severe subconjunctival hemorrhage, shallow or deep anterior chamber, hyphema, teardrop-shaped pupil, limited extraocular motility, extrusion of globe contents, reduction in visual acuity can all mean what?
Ruptured globe
-
A bright green streaming appearance to fluorescein instilled into the tear layer (Seidel test) is pathognomonic for what?
Penetrating trauma or ruptured globe
-
Treatment for ruptured globe
- Call ophthalmologist immediately.
- Metallic eye shield,
- first gen cephalosporin,
- antiemetic (prevent Valsalva),
- tetanus update,
- CT to look for foreign body.
-
How long after the first 2L of irrigation fluid should you wait to check the ph in an eye that has suffered a chemical burn?
5-10 minutes
-
What should you do for an eye that has been chemically burned and continues to have an abnormal ph despite being irrigated with 8-10 L of fluid?
The fornices should be inspected thoroughly and re-swept with a moistened tip applicator
-
What ocular condition classically presents with eye pain or headache, cloudy vision, colored halos around lights, conjunctival injection, a fixed mid-dilated pupil and increased IOP of 40-70 mmhg?
Acute angle closure glaucoma
-
What is a normal range for IOP?
10-20 mm Hg
-
What can precipitate an attack of acute angle closure glaucoma in a patient with narrow anterior chamber angles?
- Movie theaters,
- reading,
- ill-advised use of dilatory agents or inhaled anticholinergics
-
What are some treatments used to reduce IOP?
- Timolol,
- apraclonidine,
- prednisolone acetate drops
-
What can you use to decrease pressure if the IOP is greater than 50 mmhg?
Acetazolamide IV
-
What can you use to decrease IOP if it does not do so with first line agents after 1 hour?
Give 1-2g/kg mannitol IV
-
Once IOP is below 40 mmhg in acute angle closure glaucoma, what can be given as long as the patient has an intact lens in place?
Pilocarpine drops
-
Presents with acute vision loss with a particular reduction in color vision (red desaturation test), often painful especially with eoms
Optic neuritis
-
What can often be detected in Optic Neuritis?
Afferent pupillary defect
-
Presents as a sudden painless, severe monocular loss of vision, often associated with a history of amaurosis fugax
Central retinal artery occlusion
-
Causes acute, painless monocular vision loss. Examination shows optic disc edema, cotton wool spots, and retinal hemorrhages in all quadrants (blood and thunder fundus)
Central retinal vein occlusion
-
A systemic vasculitis that can cause a painless ischemic optic neuropathy?
Giant cell arteritis
-
Who is the typical patient with giant cell arteritis?
Women older than 50 years, often with a history of polymyalgia rheumatica
-
What are associated symptoms of giant cell arteritis?
- Headache,
- jaw claudication,
- scalp or temporal artery tenderness,
- fatigue,
- fever,
- anorexia
-
What is may be seen on funduscopic exam with giant cell arteritis?
Flame hemorrhages
-
What labs should be ordered when giant cell arteritis is suspected?
- Sed rate,
- c-reactive protein
-
What should be done if there is a strong suspicion of giant cell arteritis?
The patient should be admitted for methylprednisolone 250 mg IV every 6 hours
-
What may be done if there is a low suspicion for giant cell arteritis?
The patient may be discharged with prednisone with close follow up
-
Hyphema work-up
- Assume open globe;
- poss CT (if suspect blow out fx);
- poss US to r/o vitreous hemo or retinal detach;
- SPE (pts w/SCD)
-
What is the most life threatening gynecologic cause of acute abdomen in the female patient?
Ectopic pregnancy
-
Amylase is elevated in __
- Pronounced: acute pancreatitis;
- moderate: small bowel obstruction, salivary gland infxn/inflam, mumps, panc ca, perf'd peptic ulcer
-
ALT/AST is elevated in __
Hepatitis
-
Bilirubin/Alk Phosphatase is elevated in __
Common bile duct obstruction
-
Never place __ above an obstruction
Barium
-
Indications for barium studies
Volvulus, colon cancer, mucosal detail
-
Barium studies are not only useless for evaluation of __ they are dangerous
Perforation
-
For what disease process are the five F’s used for
Acute cholecystis
-
Five F’s of acute cholecystis
- Female,
- Fertile,
- Forty,
- Fat,
- Flatulent
-
Murphy’s sign is used to help diagnose __
Acute cholecystitis
-
Periumbilical pain that migrates to RLQ, anorexia is a possible history of __
Acute appendicitis
-
Obturator sign/psoas sign is used to help diagnose __
Acute appendicitis
-
__ hours after acute appendicitis symptom onset there is a >95% perforation rate
48
-
What is the rule of 2’s for Meckel’s diverticulitis?
- 2% of the pop,
- 2 feet proximal to the ileocecal valve,
- 2 types of mucosa,
- 2 years of age,
- 2:1 M:F ratio
-
What is the treatment for Meckel’s diverticulitis?
Resection
-
Severe epigastric pain radiating to the back, often associated with ETOH, usually elevated amylase/lipase
Acute pancreatitis
-
Distended abdomen, surgical scars, high pitched bowel sounds, tympanic to percussion, nausea w/ bilious vomiting, constipation, often severely dehydrated
Small bowel obstruction
-
Non-operative treatment for small bowel obstruction
- NPO,
- NGT (decompression),
- IV fluids
-
Most common causes of large bowel obstruction
- Diverticulitis,
- cancer,
- volvulus
-
LLQ pain, fever
Diverticulitis
-
Sudden onset of sharp ab pain, N/V, diarrhea, GI bleeding, pain out of proportion to physical exam, may have history of angina, atherosclerosis, smoking
Mesenteric ischemia
-
Midline ab pain with tearing sensation to the back, patients often present in shock, exam reveals pulsatile mass
Ruptured AAA
-
>__ cm AAA has an increased risk of rupture 20-30% within 5 years
5
-
Patients with __ pain tend to lie still
Peritoneal
-
Patients with __ pain tend to move about
Visceral
-
__ should be considered in any patient older than 50 with ab pain out of proportion to physical findings
Mesenteric ischemia
-
CT is the preferred imaging modality for what emergencies
Pancreatitis, biliary obstruction, aortic aneurysm, appendicitis, and urolithiasis
-
__ in appropriate doses may decrease guarding and improve localization of abdominal pain
Opiates
-
Antiemetics such as __ increase patients comfort and facilitate assessment of S/S
Metoclopramide
-
What is the most reliable symptom of appendicitis?
Abdominal pain
-
Palpation of the LLQ quadrant with pain referred to the RLQ is referred to as the __ and is indicative of __
Rovsing’s sign, acute appendicitis
-
The diagnosis of acute appendicitis is generally __
Clinical
-
The most significant predictors of acute appendicitis in the elderly are __
Tenderness, rigidity, pain at diagnosis, fever, and previous abdominal surgery
-
What are the main features of intestinal obstruction?
Crampy, intermittent, progressive ab pain
-
What causes the pseudoobstruction that commonly occurs in the low colonic region?
Depression of intestinal motility from medications such as anticholinergic agents, or tricyclic antidepressants
-
In the case of pseudoobstruction what is diagnostic as well as therapeutic
Colonoscopy
-
Predominant means of diagnosis for hernias
Physical examination
-
Should you attempt hernia reduction if there is a question about the duration of the incarceration?
No
-
__ hernias in children are common
Umbilical
-
When should a child with an umbilical hernia be referred for surgical evaluation?
Children older than 4 or with hernias greater than 2cm in diameter
-
R/LLQ pain, purulent cervical dc, CMT, adnexal tenderness =
Tubo-ovarian abscess
-
AAA risk factors
- Atherosclerosis,
- elderly,
- HTN,
- smoking,
- CTD/Marfan,
- +FH,
- hyperlipidemia
-
S/S in abd trauma
- Seat belt sx;
- Chance fx;
- Grey Turner sx;
- Cullen sx
-
Chance fx
Ecchymosis across lower abd 2/2 seat belt, assoc L-spine fx
-
Grey Turner sx
- Ecchymosis over flanks,
- usu dev after 12 hrs = retroperitoneal hemo
-
Cullen sx
- Ecchymosis over umbilicus,
- usu dev after 12 hrs = retroperitoneal hemo
-
Mesenteric ischemia: cause
Embolus to SMA 2/2 intracardiac thrombus 2/2 A-fib
-
Pancreatitis s/s
- Fever,
- tachy;
- poss tachypnea,
- hypoxia,
- dec breath sounds if pleural effusion;
- hypoactive BS,
- guarding,
- TTP;
- abd distension if ileus;
- Cullen & Gray Turner sxs if hemo
-
Pancreatitis tx
- Supportive: IVF 2/2 n/v;
- NPO, poss NG tube;
- pain ctrl
-
SBO tx
- NGT for bowel decompression;
- surg;
- IVF 2/2 n/v;
- broad abx (Flagyl, amp/ gent)
-
SBO s/s
- Colicky abd pain in waves, n/v, obstipation;
- tachy, hypotension;
- no peritoneal sxs;
- early: Distended tympanitic;
- later: tinkling BS
-
Tx for diarrhea 2/2 Shigella, Yersinia, ETEC, V cholerae
Oral quinolone
-
Infxs diarrhea: no abx for:
- SA,
- B cereus;
- salmonella,
- EHEC
-
Ranson's criteria predict M&M for:
Pancreatitis
-
What is the suspensory ligament of the duodenum?
Ligament of Treitz
-
What is the most common cause of lower GI bleeding?
Hemorrhoids
-
Common, painless and can be massive, caused from an erosion into penetrating artery from the diverticulum
Diverticulosis
-
What is the most common cause of upper GI bleed?
Peptic ulcer disease
-
Cause of esophageal and gastric varices
Portal hypertension
-
Longitudinal mucosal tear in the cardioesophageal region, caused by repeated retching
Mallory-Weiss syndrome
-
Common cause of lower GI bleeding, seen in people with hypertension and aortic stenosis
Arteriovenous malformations
-
Spider angiomata, palmer erythema, jaundice, and gynecomastia are seen in __
Liver disease
-
Petechiae and purpura seen in __
Coagulopathy
-
Why would you do a careful ENT exam on a patient suspected of GI bleed?
Rule out causes that can mimic GI bleed such as epistaxis
-
Can be diagnostic and therapeutic but requires a brisk bleed at .5-2ml/min
Angiography
-
Can only be diagnostic but are more sensitive than angiography and require a bleeding rate of only .1ml/min
Bleeding scans
-
Is diagnostic and therapeutic and more accurate than bleeding scans and angiography
Colonoscopy
-
Class __ bleed replace volume with crystalloid
I and II
-
Class __ bleed replace volume with crystalloid and blood
III and IV
-
Hemorrhaging is broken down into how many categories by the ACS
4
-
Class __ hemorrhage involves up to 15% of blood volume. There is typically no change in vital signs and fluid resuscitation is not usually necessary
I
-
Class _ hemorrhage involves 15-30% of total blood volume. A patient is often tachy, narrowed pulse pressure. Peripheral vasoconstriction, pale cool skin, slight changes in behavior, volume resuscitation with crystalloids
II
-
Class __ hemorrhage involves loss of 30-40% of blood volume; pt’s BP drops, HR increases, peripheral perfusion decreases (prolonged cap refill), mental status worsens; crystalloid & blood transfusions usually necessary
III
-
Class __ hemorrhage involves loss of >40% of blood volume; limit of body’s compensation is reached and aggressive resuscitation is required to prevent death
IV
-
__ ulcers do not extend through the muscularis mucosa
Stress
-
Only __ % of patients who are infected with H. Pylori will develop ulcers
10-20
-
Inhibits bicarbonate ion production and increases gastric emptying
Cigarette smoking
-
Main complaint of gastric ulcer
Gnawing, aching or burning epigastric pain
-
Physical exam of uncomplicated PUD, there may be a finding of __
Epigastric tenderness
-
Inhibit gastric acid secretion, equally as effective as antacids with better compliance due to decreased frequency of doses
H2 antagonists
-
Inhibits gastric acid secretions, heals ulcers faster than H2-antagonists and antacids
PPI
-
Locally binds to the base of the ulcer and therefore protects it from acid
Sucralfate
-
Prostaglandin E1 analogue which acts as natural prostaglandin in the body
Misoprostol
-
Vomiting and diarrhea is most often __
Gastroenteritis
-
Which is more common: upper or lower GI bleeding?
Upper
-
What is the most common cause of acute lower GI bleeding?
Hemorrhoids, followed by diverticular disease
-
What is the most important lab test for a patient with a significant GI bleed?
Type and crossmatch
-
When is surgical treatment for hemorrhoids indicated?
Severe, intractable pain, continued bleeding, incarceration, or strangulation
-
Treatment of choice for patients with pseudomembranous colitis
Metronidazole for mild to moderate disease in patients who do not respond to supportive measures
-
__ should be reserved for patients with pseudomembranous colitis who have not responded to or are intolerant of metronidazole and for children and pregnant patients
Vancomycin
-
For patients with pseudomembranous colitis __ may prolong or worsen symptoms and should be avoided
Antidiarrheal agents
-
Mackler triad
Sx of esophageal perf: vomiting, chest pain, subq emphysema
-
Oliguria =
Output <400 cc/day (or 0.5-1.0 cc/kg/hr)
-
Pre-renal ARF: ineffective circulating volumes; may be due to:
- Sepsis (early);
- Anaphylaxis;
- 3rd space sequestration (pancreatitis, peritonitis, ischemic bowel)
-
Renal ARF: glomerular causes
Post-infective glomerulonephritis (GAS, after 1-3 wks; pneumococcus, staph); SLE; Vasculitis; H-S purpura
-
Renal ARF: vascular causes
- Thrombosis;
- TTP/ DIC;
- NSAID OD;
- Severe HTN;
- HUS
-
Renal ARF: tx
- LD dopamine;
- Mannitol in early rhabdomyolysis;
- Dialysis
-
UTI tx
- Sulfonamides;
- FQ;
- Nitrofurantoin (safe in pregnancy);
- use 3 days;
- 7 days if: Pyelonephritis; PG; complicated, frequent utis / Prior tx failure
-
UTI: cx if:
- Pyelonephritis;
- Resistant or recurrent utis;
- Men
-
90% of stones are:
Radiopaque
-
Calcium oxalate or phosphate stones
- 75%;
- occasionally with chronic hypercalcemia (hyperparathyroidism)
-
Magnesium – ammonium – phosphate (struvite) stones
- 15%;
- secondary to recurrent infection (urease producing bacteria)
-
Uric Acid / cystine stones
History of gout
-
Stones: ddx
- AAA;
- Appendicitis;
- Tuboovarian Abscess (TOA);
- Ectopic Pregnancy
-
Urolithiasis: dx imaging
- Noncontrast CT (high sensitivity);
- US (hydronephrosis; good for PG);
- KUB (less specific)
-
Urolithiasis admit criteria
- Infection / Sepsis;
- Complete Obstruction;
- Deteriorating renal fn;
- Intractable N/V;
- Solitary kidney;
- Very large or proximal stones
-
Epididymitis has a _______ onset
Gradual
-
Spermatocele
- Asx;
- separate from & superior to testicle;
- aspiration: white cloudy fluid
-
Testicular tumor
- Firm, nontender mass;
- does not transilluminate
-
Treatment priorities for sepsis
- Oxygen,
- aggressive fluid replacement,
- vasopressors (dopamine, dobutamine, norepi, vasopressin)
-
Empiric broad spectrum antibiotics used in sepsis
- 3rd gen cephalosporins + aminoglycoside (ceftazidime and gentamicin),
- +/- vancomycin (MRSA)/clindamycin (anaerobes)
-
Recombinant human activated protein C, only FDA approved drug used solely for the treatment of sepsis in the adult patient with high risk of death. Only for use in the ICU
Xigris
-
Empiric treatment for bacterial meningitis
- Begin antibiotics immediately (ceftriaxone or cefotaxime 2 g IV and vanc.
- Add ampicillin for pts <3months/>55 and or immunocompromised
-
What do you add to empiric therapy for meningitis if HSV is suspected?
Acyclovir
-
What do you give concurrently with empiric antibiotics when treating bacterial meningitis?
Dexamethasone, continue for 4 days
-
Supportive care for bacterial meningitis
Hydration, pain meds, anticonv, antiemetics
-
Outpatient antibiotics for pneumonia
- Azithro,
- doxy,
- levo,
- cefpodoxime+azithro
-
Inpatient regimens for pneumonia
- Ceftriaxone+azithro,
- resp fluoroq,
- +/- vanc
-
Duration of tx for uncomplicated cystitis in non-pregnant women/men
3-5 days
-
What is the duration of treatment for uncomplicated cystitis in children, preg women, and complicated infections in everyone else?
7-10 days
-
Antibiotics for cystitis
- Tmp/smz,
- nitrofurantoin,
- quinolones,
- cephalexin
-
Treatment for pyelonephritis
- Cipro 7-10 days,
- levo for 7 days,
- Augmentin 10 days,
- cephalexin 10 days
-
Treatment of impetigo
- Cephalexin,
- diclox,
- mupirocin,
- retapamulin
-
Outpatient treatment for cellulitis
- Cephalexin,
- diclox,
- augmentin,
- doxy,
- minocycline,
- (MRSA) tmp/smx-bactrim or clinda
-
Inpatient treatment for cellulitis
- IV clinda,
- IV vanc +/- cefazolin
-
Treatment of a fresh bite <24 hours old
- Exploration/irrigation/immobilization,
- primary closure if face/head/neck,
- tetanus/rabies prophylaxis
-
Prophylactic antibiotics for fresh bite
- Augmentin,
- moxifloxacin,
- clindamycin + ciprofloxacin
-
Incubation of malaria in returning travelers
Varies from <2 weeks to >6 weeks
-
PID tx
Ceftriaxone + azithromycin OR doxycycline + metronidazole (outpatient)
-
Chancroid tx
Ceftriaxone or zithro (1 dose)
-
Meningitis bugs: neonates
- GBS, E coli, listeria;
- tx = amp & cefotaxime (Claforan)
-
Meningitis bugs: 1 mo - 50 yo
SP, Neisseria, H flu
-
Meningitis bugs: >50 yo / etoh
- SP, listeria;
- tx = amp + rocephin + dex
-
Meningitis tx: 1 - 3 mos
Amp + (rocephin or cefotaxime) + Dex
-
Meningitis tx: 3 mos - 50 yo
(rocephin or cefotaxime) + vanc + Dex
-
PEP for meningitis
- Post exposure prophylaxis = rifampin for household contacts/droplet exp only;
- alts = cipro or rocephin
-
Labs to get in the w/u of sepsis
- CBC,
- chems (lfts, bicarb, creatinine),
- PT/PTT,
- Lactate
-
An important marker of global tissue hypoxia
Lactate
-
Additional labs to evaluate source of sepsis
- Blood cultures,
- UA,
- urine C & S,
- CXR,
- discharge from lesions,
- sterile fluids if suspected
-
CSF tube 1 is used for what purpose
Appearance; cell count/diff
-
CSF tube 2 is used for what purpose
Glucose and protein
-
CSF tube 3 is used for what purpose
Gram stain and culture
-
CSF tube 4 is used for what purpose
Cell count with differential
-
What patients with cystitis should get a urine culture?
Anyone who is not a healthy young female
-
Pneumonia labs
- CBC;
- CXR;
- sputum gr stain/cx;
- Blood cx;
- Pulse ox,
- ABG;
- Urine for streptococcal and Legionella antigen;
- PCR assays;
- Serologies;
- Influenza rapid antigen
-
Septic arthritis: Joint fluid analysis
- Cell count/diff (WBC <200 normal; septic >50-60K);
- Diff: <25% PMN normal;
- >50% PMN infxs/inflam;
- Gr stain/cx;
- Crystals
-
What should be included in the workup for central retinal artery occlusion?
ESR for temporal arteritis
-
What should be done in the case of orbital cellulitis?
Emergent CT of the orbits and sinuses, ophthalmologic consultation and admission for cefuroxime IV
-
What is the preferred topical ocular anesthetic used when assessing a corneal abrasion
Proparacaine
-
How will a corneal abrasion appear during fluorescein stain when using cobalt blue light on slit lamp
It will fluoresce green
-
A hyphema should be dilated with __ to prevent pupillary movement from tearing damaged blood vessels
Atropine 1%
-
A bright green streaming appearance to fluorescein instilled into the tear layer (Seidel test) is pathognomonic for what
Penetrating trauma or ruptured globe
-
What is a normal range for IOP?
10-20 mm Hg
-
What may be seen on funduscopic exam with giant cell arteritis?
Flame hemorrhages
-
What labs should be ordered when giant cell arteritis is suspected?
Sed rate,c-reactive protein
-
Hyphema work-up
- Assume open globe;
- poss CT (if suspect blow out fx);
- poss US to r/o vitreous hemo or retinal detach;
- SPE (pts w/SCD)
-
-
AAA imaging
Xray: calcified arch or paravert ST mass; u/s accurate for dx/measuring diameter; CT most sensitive for ruptured AAA
-
Imaging modality of choice for acute pancreatitis
CT
-
Imaging modality of choice for aortic aneurysm
CT
-
Imaging modality of choice for acute appy
CT w/contrast: shows walls >2mm, abscess, free fluid, RLQ fat stranding, appendicolith
-
Imaging modality of choice for biliary obstruction
U/s is definitive initial test for GS; u/s or HIDA for cholecystitis; xray/CT for porcelain; u/s or ERCP for choledocho
-
GI bleed labs
CMP, CBC (H&H), type & cross, coags; BUN often elevated 2/2 GI blood breakdown; ECG; poss NG tube to distinguish upper/lower
-
GIB: angiography requires bleeding rates of:
0.5 - 2.0 ml/min
-
Imaging TOC for upper GIB =
Endoscopy
-
GIB IVF resuscitation
3:1 rule - 3L crystalloid per 1L blood lost
-
GIB rfs
- ETOH,
- NSAIDs,
- steroids,
- anticoag meds
-
Mesenteric ischemia TOC
- Angio/CTA;
- abd xray/CT shows wall thickening / pneumatosis intestinalis
-
Biliary labs
- ECG,
- CBC,
- lytes,
- LFTs,
- bili, amylase,
- lipase,
- UA,
- bhCG
-
-
What radiographs should be obtained to assess for intestinal obstruction
Flat and upright abdominal, and upright chest
-
Pancreatitis labs
- Elev WBC,
- hypocalcemia;
- Sens/Sens: lipase > amylase (both high in acute)
-
-
Fever (>38C), <28 days old
- Admit;
- ucc,
- blood cx,
- LP,
- poss cxr;
- IV amp/gent
-
Fever (>38C), 28 day - 3 mos
- Ucc,
- blood cx,
- LP,
- poss cxr;
- Rocephin 50 mg/kg;
- dc if cxs neg;
- f/u in 24hr
-
Fever (>39C), 3 mos - 3 yo
- Ucc,
- poss cxr,
- stool cx; close f/u
-
Imaging TOC for pyloric stenosis
- U/S;
- spec, not always sensitive;
- 2nd line: upper GI series: shows string sign
-
Imaging TOC for PE
- ECG, CXR (atelectasis, pl effusion, elev hemidiaphragm); gold std = pulmonary angiogram, but
- Invasive (mort = 1-5%), so most 1st order V/Q scan
-
Testing for suspected stroke
- Glucose,
- EKG,
- lytes,
- CBC,
- coag
-
Imaging tests for stroke
- CT: noncontrast detects hemo, ischemic visible after 6 hrs;
- MRI sensitive for posterior fossa or <6 hr;
- gold std: angio
-
Meningitis testing
- CBC,
- coag,
- blood cx;
- CT (r/o mass lesion) before LP;
- empiric abx
-
CSF, viral meningitis
- Opening pressure <200,
- WBC <1000 & <50% PMN,
- glucose >40,
- pro <200,
- neg Gr Stain / cx
-
CSF, bacterial meningitis
- Opening pressure >300,
- WBC >1000 & >80% PMN,
- glu <40,
- pro >200,
- pos Gr Stain / Cx
-
Seizure labs
- Anticonvulsant levels;
- lytes,
- glu,
- tox screen,
- poss CK;
- poss LP
-
Seizure tx
- 1stline: benzos (versed, Ativan, valium),
- poss phenobarb;
- 2ndline: Dilantin, Depakote;
- Mg sulfate: eclampsia
-
Status epilepticus tx
- Pentobarb infusion (coma),
- isoflurane aesthesia
-
SAH testing
- CT 90% sensitive, esp within 12 hrs;
- LP 98%, esp >12 hrs, when xanthochromia present
-
AMI labs: troponin
Troponin rises first & stays high 5 to 14 days, and is most sensitive/specific for MI
-
AMI labs: CK-MB
CKMB rises within 4 hours and peaks at 24 hrs
-
CHF xray
- Cardiomegaly,
- pulmo edema (plump vessels, interstitial / alveolar edema, Kerley B lines)
-
Imaging for aortic dissection
- CXR: widened mediastinum, poss tracheal deviation to right, left hemothorax;
- CT contrast;
- TEE to ID type & valvular involvement;
- aortography is gold std but invasive
-
Feeling of difficult, labored or uncomfortable breathing
Dyspnea
-
Rapid physical exam for respiratory distress
- Oropharynx,
- neck,
- cardiac,
- chest exam,
- pulmonary,
- skin
-
What do you look for in the oropharynx in the setting of respiratory distress?
Appearance of uvula, foreign body
-
What do you look for in the neck exam in the setting of respiratory distress?
Tracheal deviation, distended neck veins, stridor
-
What do you look for in the cardiac exam in the setting of respiratory distress?
Rate and rhythm
-
What do you look for in the chest exam in the setting of respiratory distress?
Equal rise, trauma
-
What do you look for in the pulmonary exam in the setting of respiratory distress?
Rales, crackles, wheezing, equal breath sounds
-
What do you look for in the skin exam in the setting of respiratory distress?
Color, temperature, diaphoresis
-
Arbitrarily defined as a Pao2<60mmhg, correlates with O2 sat 90%
Hypoxia
-
Segmental fracture of 3 or more adjacent ribs in two or more places of each individual rib, results in paradoxical respiration
Flail chest
-
Tall lanky guy who smokes, with sudden onset of dyspnea, what is it?
Tension pneumothorax
-
Chest pain worse on breathing in, leaning forward, and on palpation
Pleuritic chest pain
-
Accumulation of fluid in alveoli resulting in impaired gas exchanged and subsequent hypoxia
Pulmonary edema
-
Characterized by inflamed airway tissue and excessive mucus production
COPD
-
COPD treatment
Steroids, use of NIPPV:CPAP or bipap, careful use of O2 (goal of pao2 at least 60mmhg), broad spectrum antibiotics
-
History: pleuritic chest pain, dyspnea (may be intermittent), cough, hemoptysis, anxiety. Physical findings: tachypnea, tachycardia, fever, hypotension, signs of DVT. What is it
Pulmonary embolism
-
Do you get a d-dimer on patients who you have a high suspicion or low suspicion for pulmonary embolism
Low
-
Cornerstone of treatment for pulmonary embolism
LMWH, heparin, Coumadin
-
Biggest reason to perform the Sellick maneuver
To prevent aspiration
-
Flail chest: indicators for early intubation include
Persistent arterial Po2<80, shock, age>65, severe head injury, comorbid pulmonary disease
-
What should be done immediately for the patient with a tension pneumo?
14-16 ga catheter should be inserted into anterior chest wall (2nd intercostal space at midclavicular line)
-
What is the definitive treatment for a tension pneumo?
Inflation of affected lung with evacuation of pleural air via a chest tube
-
Who is at risk for aspiration pneumonia?
Nursing home patients, alcoholics, patients on sedatives, narcotics users, patients with GERD
-
What are some causes of non-cardiogenic pulmonary edema?
Drug overdose, sepsis, pulmonary contusion
-
Treatment for pulmonary edema
- 100% O2,
- noninvasive positive pressure vent CPAP or bipap (consider intubation for obtunded patients),
- NTG,
- morphine,
- diuretics (Lasix),
- Foley (for the Lasix you just gave),
- treat underlying cause
-
What are the two phases of asthma?
- Acute bronchoconstriction,
- sub-acute airway inflammation and mucous plugging
-
What are some ominous signs of impending respiratory failure in someone with asthma?
A quiet chest, agitation or confusion
-
What are red flags in an asthma patient?
Fever, productive cough, immunosuppression, elderly or very young
-
Asthma treatment
- Supplemental oxygen,
- beta agonist (albuterol/smooth muscle relaxation),
- anticholinergic (Atrovent/decreased mucous production),
- epinephrine (if impending resp failure),
- steroids (treat late phase and prevent rebound)
-
Characterized by inflamed airway tissue and excessive mucus production. Coughing on most days for 3 month in 2 consecutive years
COPD
-
Alveoli loose ability to stretch and thus become weak, and break resulting in inability of the lung to exchange CO2 and O2
Emphysema
-
What is the treatment goal of COPD?
Pao2 of at least 60mmhg
-
What are some hypercoagulable states (in PE)?
Malignancy, pregnancy, postpartum, estrogen use, genetic mutations, Pro C/S deficiency
-
Risk factors for pulmonary embolism
Hyper-coagulable state, vascular injury, venous stasis
-
Bed rest > __ hours can lead to venous stasis and put the patient at risk for PE
48
-
Gold standard for the diagnosis of PE
Pulmonary angiography
-
Causes of cardiogenic pulmonary edema
- H/O CHF or ESRD,
- new onset arrhythmia,
- medication noncompliance,
- dietary indiscretion
-
Pulmonary edema: ancillary tests
- Pulse Ox,
- blood gas,
- BNP,
- chemistry,
- cardiac markers,
- EKG;
- Urine/Serum,
- toxicology screen
-
Pulmonary embolism: ancillary imaging tests
- Doppler US;
- CT (may miss small peripheral PE);
- V/Q scan;
- pulmonary angiography
-
Pulmonary embolism: tx
- Anticoagulation (cornerstone of tx; LMWH, hep, warfarin);
- thrombolysis (for pts in extremes);
- embolectomy (rare);
- IVC filter (recurrent DVT/PE pt on anticoag)
-
Miller laryngoscope blade
- Straight;
- Lifts epiglottis directly
-
Macintosh laryngoscope blade
- Curved;
- Lifts vallecula (indirectly lifting epiglottis)
-
ET tube sizes
- M 8.0-8.5;
- F 7.0-7.5;
- infants/kids: estimate by diameter of pinky finger
-
LEMON
- Look externally;
- Evaluate 3-3-2;
- Mallampati;
- Obstruction;
- Neck mobility
-
BURP
- Backward,
- Upward,
- Rightward,
- Pressure on thyroid cartilage (studies don't support benefit of either maneuver)
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