shosh: vasculitides

  1. Wegener's granulomatosis
    • Triad of necrotizing vasculitis, granulomas in the lungs and URT, and necrotizing glomerulonephritis
    • Affects small vessels
    • Patients may present with hemoptysis, hematuria, sinusitis
    • c-ANCA and nodular densities on CXR
    • Treat with cyclophosphamide
  2. Microscopic polyangitis
    • Vasculitis of small vessels
    • p-ANCA
    • No granulomas
  3. Churg-Strauss
    • Granulomatous vasculitis
    • Can present with skin lesions and peripheral neuropathy (e.g. foot/wrist drop)
    • Seen in asthmatics
  4. Sturge-Weber disease
    • Congenital disorder of capillaries
    • Port-wine stains on face
    • Seizures
    • Early-onset glaucoma
  5. Henoch-Schonlein Purpura
    • Common childhood vasculitis
    • Presents with palpable purpura on buttocks and legs
    • Triad of skin, joints, and GI tract
    • Follows URIs
    • Associated with IgA nephropathy
  6. Buerger's disease
    • Segmental obliteration of small and medium blood vessel lumina
    • Seen in smokers
    • Intermittent claudication of vessels
    • Classically involves lower extremities
    • Inflammation extends from artery to vein and nerve
  7. Kawasaki's disease
    • Necrotizing vasculitis of small vessels (often coronary vessels), seen in Asian children
    • Fever, conjunctivitis, "strawberry tongue," lymphadenitis
    • Often self-limiting
    • Treat with IvIg and aspirin
  8. Polyarteritis Nodosa
    • Immune complex mediated transmural vasculitis with fibrinoid necrosis
    • Affects renal and visceral vessels
    • Many patients are HBV positive (seen in IV drug users)
  9. Takayasu's arteritis
    • Granulomatous thickening of aortic arch and proximal great vessels
    • Loss of pulse in upper extremities ("pulseless disease")
    • Fever, myalgia, night sweats, skin nodules, ocular disturbances
    • Affects young Asian women
  10. Temporal arteritis
    • Most common vasculitis
    • Affects medium and large arteries, typically the temporal artery
    • Granulomatous inflammation
    • Affects older women
    • Symptoms include unilateral headache, jaw claudication, impaired vision
  11. Polymyalgia rheumatica
    • Temporal arteritis with systemic involvement
    • Presents with temporal arteritis, flu-like symptoms, and joint pain
  12. Raynaud's
    • Episodic arterial vasospasm in the extremities
    • Can be primary, or secondary to SLE, Buerger's, scleroderma, or CREST
Card Set
shosh: vasculitides
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